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NIGMS Image and Video Gallery Public Item

A light microscope image of a cell from the endosperm of an African globe lily (<i>Scadoxus katherinae</i>). This is one frame of a time-lapse sequence that shows cell division in action. The lily is considered a good organism for studying cell division because its chromosomes are much thicker and easier to see than human ones. Staining shows microtubules in red and chromosomes in blue. Here, condensed chromosomes are clearly visible and lined up. <Br><Br>Related to images
<a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1010">1010</a>,  <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1011">1011</a>,  <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1012">1012</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1013">1013</a>,  <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1014">1014</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1015">1015</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1016">1016</a>,  <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1017">1017</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1018">1018</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1019">1019</a>.

Andrew S. Bajer, University of Oregon, Eugene

(Bulk import) [OCPL Contact: Alisa Machalek] [Similar images: lilymit1-13(1), series of 14]

Andrew S. Bajer (not an NIGMS grantee)

DNA

Not used

Andrew S. Bajer, University of Oregon, Eugene

Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). This image is part of a series of images: <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1047">image 1047</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1048">image 1048</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1049">image 1049</a>,&nbsp; <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1051">image 1051</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1052">image 1052</a>.

George von Dassow, University of Washington

[OCPL Contact: Karin Jegalian] Received from George von Dassow
of Odell lab, when searching for cool image for Biomedical
Beat.None of the images in this series were used. Instead, used
myo2.
12/20/07 to KJ: Of course you are welcome to use them; the
NIGMS paid for their creation after all!  Please let me know if you
need anything else.
(2/11/05 note-description of how to view stereo triplets)

Garrett Odell, CBCB

cell, division, development

Not used

George von Dassow, University of Washington

Many researchers use the mouse <i>(Mus musculus)</i> as a model organism to study mammalian biology. Mice carry out practically all the same life processes as humans and, because of their small size and short generation times, are easily raised in labs. Scientists studying a certain cellular activity or disease can choose from tens of thousands of specially bred strains of mice to select those prone to developing certain tumors, neurological diseases, metabolic disorders, premature aging, or other conditions.

Bill Branson, National Institutes of Health, Bethesda, MD

N/A

research organism

CCC

Bill Branson, National Institutes of Health

A light microscope image of a cell from the endosperm of an African globe lily (<i>Scadoxus katherinae</i>). This is one frame of a time-lapse sequence that shows cell division in action. The lily is considered a good organism for studying cell division because its chromosomes are much thicker and easier to see than human ones. Staining shows microtubules in red and chromosomes in blue. Here, condensed chromosomes are clearly visible. <Br><Br>Related to images
<a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1010">1010</a>,  <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1011">1011</a>,  <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1012">1012</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1013">1013</a>,  <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1014">1014</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1016">1016</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1017">1017</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1018">1018</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1019">1019</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1021">1021</a>. 

Andrew S. Bajer, University of Oregon, Eugene

(Bulk import) [OCPL Contact: Alisa Machalek] [Similar images: lilymit1-13(1), series of 14]

Andrew S. Bajer (not an NIGMS grantee)

DNA, nucleus

Not used

Andrew S. Bajer, University of Oregon, Eugene

Microarrays, also called gene chips, are tools that let scientists track the activity of hundreds or thousands of genes simultaneously. For example, researchers can compare the activities of genes in healthy and diseased cells, allowing the scientists to pinpoint which genes and cell processes might be involved in the development of a disease.

Juanita Martinez, Angelina Rodriguez of the Werner-Washburne lab

(Bulk import) [OCPL Contact: Alisa Machalek]

Maggie Werner-Washburne, GDB

genetics, DNA, RNA

CCC

Maggie Werner-Washburne, University of New Mexico, Albuquerque

Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). This image is part of a series of images: <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1047">1047</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1049">1049</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1050">1050</a>,  <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1051">1051</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1052">1052</a>.

George von Dassow, University of Washington

[OCPL Contact: Karin Jegalian] Received from George von Dassow of Odell lab, when searching for cool image for Biomedical
Beat.None of the images in this series were used. Instead, used
myo2.
12/20/07 to KJ: Of course you are welcome to use them; the
NIGMS paid for their creation after all!  Please let me know if you
need anything else.
(2/11/05 note-description of how to view stereo triplets)

Garrett Odell, CBCB

Cell, division, mitosis, development

Not used

George von Dassow, University of Washington

Cross-section of skin anatomy shows layers and different tissue types.

National Institute of General Medical Sciences

(Bulk import) [OCPL Contact: Alison Davis] [Similar images: 300skin8inch]

N/A

epidermis, dermis, hair follicle, sweat gland, fibroblasts, blood vessel

6/18/99 fact sheet

National Institutes of Health Medical Arts

A light microscope image of a cell from the endosperm of an African globe lily (<i>Scadoxus katherinae</i>). This is one frame of a time-lapse sequence that shows cell division in action. The lily is considered a good organism for studying cell division because its chromosomes are much thicker and easier to see than human ones. Staining shows microtubules in red and chromosomes in blue. <Br><Br>Related to images
<a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1010">1010</a>,  <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1011">1011</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1013">1013</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1014">1014</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1015">1015</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1016">1016</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1017">1017</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1018">1018</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1019">1019</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1021">1021</a>. 

Andrew S. Bajer, University of Oregon, Eugene

(Bulk import) [OCPL Contact: Alisa Machalek] [Similar images: lilymit1-13(1), series of 14]

Andrew S. Bajer (not an NIGMS grantee)

DNA, nucleus

Not used

Andrew S. Bajer, University of Oregon, Eugene

A light microscope image of a cell from the endosperm of an African globe lily (<i>Scadoxus katherinae</i>). This is one frame of a time-lapse sequence that shows cell division in action. The lily is considered a good organism for studying cell division because its chromosomes are much thicker and easier to see than human ones. Staining shows microtubules in red and chromosomes in blue. Here, condensed chromosomes are clearly visible near the end of a round of mitosis. <Br><Br>Related to images
<a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1010">1010</a>,  <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1011">1011</a>,  <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1012">1012</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1013">1013</a>,  <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1014">1014</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1015">1015</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1016">1016</a>,  <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1017">1017</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1019">1019</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1021">1021</a>. 

Andrew S. Bajer, University of Oregon, Eugene

(Bulk import) [OCPL Contact: Alisa Machalek] [Similar images: lilymit1-13(1), series of 14]

Andrew S. Bajer (not an NIGMS grantee)

DNA

Not used

Andrew S. Bajer, University of Oregon, Eugene

A light microscope image of cells from the endosperm of an African globe lily (<i>Scadoxus katherinae</i>). This is one frame of a time-lapse sequence that shows cell division in action. The lily is considered a good organism for studying cell division because its chromosomes are much thicker and easier to see than human ones. Staining shows microtubules in red and chromosomes in blue. Here, condensed chromosomes are clearly visible and have separated into the opposite sides of a dividing cell. <Br><Br>Related to images
<a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1010">1010</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1012">1012</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1013">1013</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1014">1014</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1015">1015</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1016">1016</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1017">1017</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1018">1018</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1019">1019</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1021">1021</a>. 

Andrew S. Bajer, University of Oregon, Eugene

(Bulk import) [OCPL Contact: Alisa Machalek] [Similar images: lilymit1-13(1), series of 14]

Andrew S. Bajer (not an NIGMS grantee)

DNA, heredity

Not used

Andrew S. Bajer, University of Oregon, Eugene

Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). This image is part of a series of images: <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1047">1047</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1048">1048</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1049">1049</a>,  <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1050">1050</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=1051">1051</a>.

George von Dassow, University of Washington

[OCPL Contact: Karin Jegalian] Received from George von Dassow
of Odell lab, when searching for cool image for Biomedical
Beat.None of the images in this series were used. Instead, used
myo2.
12/20/07 to KJ: Of course you are welcome to use them; the
NIGMS paid for their creation after all!  Please let me know if you
need anything else.
(2/11/05 note-description of how to view stereo triplets)

Garrett Odell, CBCB

cell, division, development

Not used

George von Dassow, University of Washington

Structural biologists create crystals of proteins, shown here, as a first step in a process called X-ray crystallography, which can reveal detailed, three-dimensional protein structures.

Alex McPherson, University of California, Irvine

(Bulk import) [OCPL Contact: Alisa Machalek] [Similar images: N/A] F04101GMS 0226d2.tif

Alex McPherson, CBB

microscopy

CCC

Alex McPherson, University of California, Irvine

Glial cells (stained green) in a fruit fly developing embryo have survived thanks to a signaling pathway initiated by neighboring nerve cells (stained red).

Andreas Bergmann and Hermann Steller, Rockefeller University

[OCPL Contact: Kirstie Saltsman]  A. Bergmann is former postdoc of Steller lab.
Steller granted permission to use in other NIH print and online publications.

Hermann Steller, GDB

microscopy, neuron

ITC

Hermann Steller, Rockefeller University

NIGMS staff are located in the Natcher Building on the NIH campus.

Alisa Machalek, National Institute of General Medical Sciences

(Bulk import) [OCPL Contact: Alisa Machalek] [Similar images: Natcher1, 3-7, 2005-04-14-008, 2005-04-14-009, 2005-04-14-010]

N/A

offices

Not used

Alisa Machalek, National Institute of General Medical Sciences

This image shows two components of the cytoskeleton, microtubules (green) and actin filaments (red), in an endothelial cell derived from a cow lung. The cystoskeleton provides the cell with an inner framework and enables it to move and change shape.

Tina Weatherby Carvalho, University of Hawaii at Manoa

(Bulk import) {see caption}[OCPL Contact: Alisa Machalek]
Permitted to use as like; would be nice to send her copy of pubs that use her image. From 12/19/07 email correspondence between AZM and Carvalho:
Sure, so ahead and use them. You can probably also use the pretty cell - it's just a random shot off a prepared slide used to show all the colors are working. No problem with intellectual property there.
Aloha, Tina
> Thanks! So, would we have permission to use these on our publicly
> accessible image gallery (with the possible exception of prettycell?)
>
> Alisa
Original name for this image: prettycellb.tif

N/A

microscopy

Tina Weatherby Carvalho, University of Hawaii at Manoa

NIGMS staff are located in the Natcher Building on the NIH campus.

Alisa Machalek, National Institute of General Medical Sciences

(Bulk import) [OCPL Contact: Alisa Machalek] [Similar images: Natcher1-7, 2005-04-14-008, 2005-04-14-009]

N/A

offices

Not used

Alisa Machalek, National Institute of General Medical Sciences

NIGMS staff are located in the Natcher Building on the NIH campus.

Alisa Machalek, National Institute of General Medical Sciences

(Bulk import) [OCPL Contact: Alisa Machalek] [Similar images: Natcher1-5, 7, 2005-04-14-008, 2005-04-14-009, 2005-04-14-010]

N/A

offices

Not used

Alisa Machalek, National Institute of General Medical Sciences

NIGMS staff are located in the Natcher Building on the NIH campus.

Alisa Machalek, National Institute of General Medical Sciences

(Bulk import) [OCPL Contact: Alisa Machalek] [Similar images: Natcher1-4, 6-7, 2005-04-14-008, 2005-04-14-009, 2005-04-14-010]

N/A

offices

Not used

Alisa Machalek, National Institute of General Medical Sciences

This image of human red blood cells was obtained with the help of a scanning electron microscope, an instrument that uses a finely focused electron beam to yield detailed images of the surface of a sample.

Tina Weatherby Carvalho, University of Hawaii at Manoa

(Bulk import) {see caption}[OCPL Contact: Alisa Machalek]
Permitted to use as like; would be nice to send her copy of pubs that use her image.
This from a 12/19/07 email from Carvalho:  Rbcg.tif
>
> SEM of red blood cells, probably human, came from Rocky Mtn. labs
Permission info, from 12/19/07 email:
From: Tina Carvalho [mailto:tina@pbrc.hawaii.edu]
Sent: Wednesday, December 19, 2007 1:15 PM
To: Machalek, Alisa Zapp (NIH/NIGMS) [E]
Subject: RE: Your images for NIGMS gallery
Sure, so ahead and use them. You can probably also use the pretty cell - it's just a random shot off a prepared slide used to show all the colors are working. No problem with intellectual property there.
Aloha, Tina
> Thanks! So, would we have permission to use these on our publicly
> accessible image gallery (with the possible exception of prettycell?)
>
> Alisa

N/A

erythrocytes

Tina Weatherby Carvalho, University of Hawaii at Manoa

Image of <i>Streptococcus</i>, a type (genus) of spherical bacteria that can colonize the throat and back of the mouth. Stroptococci often occur in pairs or in chains, as shown here.

Tina Weatherby Carvalho, University of Hawaii at Manoa

(Bulk import) [OCPL Contact: Alisa Machalek] [Similar images: strept1]
Description, from 12/19/07 email from Carvalho:
Strep1color.tif
>
> SEM of streptococcus, original image from Rocky Mtn lab, colorized by
> me
Permission, from 12/19/07 email:
From: Tina Carvalho [mailto:tina@pbrc.hawaii.edu]
Sent: Wednesday, December 19, 2007 1:15 PM
To: Machalek, Alisa Zapp (NIH/NIGMS) [E]
Subject: RE: Your images for NIGMS gallery
Sure, so ahead and use them. You can probably also use the pretty cell - it's just a random shot off a prepared slide used to show all the colors are working. No problem with intellectual property there.
Aloha, Tina
> Thanks! So, would we have permission to use these on our publicly
> accessible image gallery (with the possible exception of prettycell?)
>
> Alisa

Not a grantee

infection

Not used

Tina Weatherby Carvalho, University of Hawaii at Manoa

<i>Leptospira</i>, shown here in green, is a type (genus) of elongated, spiral-shaped bacteria. Infection can cause Weil's disease, a kind of jaundice, in humans.

Tina Weatherby Carvalho, University of Hawaii at Manoa

(Bulk import) [OCPL Contact: Alisa Machalek]
Previous name of image: Leptoc2color
Description (from Carvalho):
> SEM of Leptospira on a 0.22 micrometer filter, from researcher across
> the hall. He wasn't sure what the yellow things were; either a sort of
> spore stage, or a contaminant!
Permission (from 12/19/07 email to AZM):
From: Tina Carvalho [mailto:tina@pbrc.hawaii.edu]
Sent: Wednesday, December 19, 2007 1:15 PM
To: Machalek, Alisa Zapp (NIH/NIGMS) [E]
Subject: RE: Your images for NIGMS gallery
Sure, so ahead and use them. You can probably also use the pretty cell - it's just a random shot off a prepared slide used to show all the colors are working. No problem with intellectual property there.
Aloha, Tina
> Thanks! So, would we have permission to use these on our publicly
> accessible image gallery (with the possible exception of prettycell?)
>
> Alisa

Not a grantee

SEM

Not used

Tina Weatherby Carvalho, University of Hawaii at Manoa

This transmission electron micrograph shows sections of mouse sperm tails, or flagella.

Tina Weatherby Carvalho, University of Hawaii at Manoa

(Bulk import) [OCPL Contact: Alisa Machalek]
Previous name for this image: Sperm9X2c.tif
Description (provided by Carvalho): TEM of section through a pellet of mouse sperm, showing head,
> acrosome, tail with coil fo mitochondria, some tails in cross section
Permission info (from email to AZM):
From: Tina Carvalho [mailto:tina@pbrc.hawaii.edu]
Sent: Wednesday, December 19, 2007 1:15 PM
To: Machalek, Alisa Zapp (NIH/NIGMS) [E]
Subject: RE: Your images for NIGMS gallery
Sure, so ahead and use them. You can probably also use the pretty cell - it's just a random shot off a prepared slide used to show all the colors are working. No problem with intellectual property there.
Aloha, Tina
> Thanks! So, would we have permission to use these on our publicly
> accessible image gallery (with the possible exception of prettycell?)
>
> Alisa

Not a grantee

Tina Weatherby Carvalho, University of Hawaii at Manoa

Colorized scanning electron micrographs progressively zoom in on the eye of a crab larva. In the higher-resolution frames, bacteria are visible on the eye.

Tina Weatherby Carvalho, University of Hawaii at Manoa

(Bulk import) [OCPL Contact: Alisa Machalek] File name: crablarva-bacteria-eye.tif
Contact: Tina Carvalho
University of Hawaii
Research Associate
Biological Electron Microscope Facility
Pacific Biomedical Research Center
1993 East-West Road
Honolulu, HI 96822
office: Snyder Rm. 118
phone: 956-6251
fax: 956-5043
email: tina@pbrc.hawaii.edu

Not a grantee

SEM

Tina Weatherby Carvalho, University of Hawaii at Manoa

The signal is obtained by allowing proteins in human serum to interact with glycan (polysaccharide) arrays. The arrays are shown in replicate so the pattern is clear. Each spot contains a specific type of glycan. Proteins have bound to the spots highlighted in green.

Ola Blixt, Scripps Research Institute

{see caption}[OCPL Contact: Alisa Machalek] [Similar images: Human serum 4x4 grid] Blixt is a research scientist. See Blixt or Richard Alvarez (OUHSC), also a member of CFG, for more info. Human serum 2x2 grid.jpg

Part of Consortium for Functional Glycomics Center

microarray

Ola Blixt, Scripps Research Institute

A scanning electron microscope picture of a nerve ending. It has been broken open to reveal vesicles (orange and blue) containing chemicals used to pass messages in the nervous system.

Tina Weatherby Carvalho, University of Hawaii at Manoa

(Bulk import) [OCPL Contact: Alisa Machalek] Contact: Tina Carvalho
University of Hawaii
Research Associate
Biological Electron Microscope Facility
Pacific Biomedical Research Center
1993 East-West Road
Honolulu, HI 96822
office: Snyder Rm. 118
phone: 956-6251
fax: 956-5043
email: tina@pbrc.hawaii.edu

Not a grantee

https://reporter.nih.gov/search/t8ywfdizlEqeQTMjSFR9SQ/project-details/10488598

SEM

Inside the Cell

Tina Weatherby Carvalho, University of Hawaii at Manoa

<i>Borrelia burgdorferi</i> is a spirochete, a class of long, slender bacteria that typically take on a coiled shape. Infection with this bacterium causes Lyme disease.

Tina Weatherby Carvalho, University of Hawaii at Manoa

(Bulk import) [OCPL Contact: Alisa Machalek] [Similar images: lyme4-negbw]
Previous name for this image:
 Lyme4-neg.tif
Description (provided by Carvalho): TEM of negative stained bacterium that causes Lyme disease, from Rocky
> Mtn lab
Permission info (from email to AZM):
From: Tina Carvalho [mailto:tina@pbrc.hawaii.edu]
Sent: Wednesday, December 19, 2007 1:15 PM
To: Machalek, Alisa Zapp (NIH/NIGMS) [E]
Subject: RE: Your images for NIGMS gallery
Sure, so ahead and use them. You can probably also use the pretty cell - it's just a random shot off a prepared slide used to show all the colors are working. No problem with intellectual property there.
Aloha, Tina
> Thanks! So, would we have permission to use these on our publicly
> accessible image gallery (with the possible exception of prettycell?)
>
> Alisa

Not a grantee

TEM, transmission electron microscope

Tina Weatherby Carvalho, University of Hawaii at Manoa

The three fibers of the cytoskeleton--microtubules in blue, intermediate filaments in red, and actin in green--play countless roles in the cell.

Judith Stoffer

(Bulk import) [OCPL Contact: Alisa Machalek]  ITC_Cytoskeleton Copy.tif   Judith A. Stoffer, MA, CMI
jStoffer Medical Illustration
Phone: 443/676.8883
FAX: 443/946.0205
www.jStoffer.com
judy@jStoffer.com

N/A

cell, drawing

Inside the Cell

Judith Stoffer

Cells function within organs and tissues, such as the lungs, heart, intestines, and kidney.

Judith Stoffer

(Bulk import) [OCPL Contact: Alisa Machalek] Judith A. Stoffer, MA, CMI
jStoffer Medical Illustration
Phone: 443/676.8883
FAX: 443/946.0205
www.jStoffer.com
judy@jStoffer.com

N/A

human, body, heart, lung, kidney, intestine

Inside the Cell

Judith Stoffer

Two models for how material passes through the Golgi apparatus: the vesicular shuttle model and the cisternae maturation model.

Judith Stoffer

(Bulk import) [OCPL Contact: Alisa Machalek]  ITC_GolgiTheories Copy.jpg  Judith A. Stoffer, MA, CMI
jStoffer Medical Illustration
Phone: 443/676.8883
FAX: 443/946.0205
www.jStoffer.com
judy@jStoffer.com

You can see animations of the two different models at <a href="http://publications.nigms.nih.gov/insidethecell/extras/" target="_blank">http://publications.nigms.nih.gov/insidethecell/extras/</a>.

N/A

endoplasmic reticulum, cell

ITC

Judith Stoffer

Ribosomes manufacture proteins based on mRNA instructions. Each ribosome reads mRNA, recruits tRNA molecules to fetch amino acids, and assembles the amino acids in the proper order.

Judith Stoffer

(Bulk import) [OCPL Contact: Alisa Machalek]  ITC_Translation Copy.tif
Judith A. Stoffer, MA, CMI
jStoffer Medical Illustration
Phone: 443/676.8883
FAX: 443/946.0205
www.jStoffer.com
judy@jStoffer.com

N/A

protein

Inside the Cell

Judith Stoffer

This illustration shows vesicle traffic inside a cell. The double membrane that bounds the nucleus flows into the ribosome-studded rough endoplasmic reticulum (purple), where membrane-embedded proteins are manufactured. Proteins are processed and lipids are manufactured in the smooth endoplasmic reticulum (blue) and Golgi apparatus (green). Vesicles that fuse with the cell membrane release their contents outside the cell. The cell can also take in material from outside by having vesicles pinch off from the cell membrane.

Judith Stoffer

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Judith A. Stoffer, MA, CMI
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organelle, exocytosis

Inside the Cell

Judith Stoffer

The membrane that surrounds a cell is made up of proteins and lipids. Depending on the membrane's location and role in the body, lipids can make up anywhere from 20 to 80 percent of the membrane, with the remainder being proteins. Cholesterol (green), which is not found in plant cells, is a type of lipid that helps stiffen the membrane.

Judith Stoffer

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cell

Inside the cell

Judith Stoffer

Bean-shaped mitochondria are cells' power plants. These organelles have their own DNA and replicate independently. The highly folded inner membranes are the site of energy generation.

Judith Stoffer

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cell, organelle

Inside the Cell

Judith Stoffer

The nucleus contains the DNA of eukaryotic cells. The double membrane that bounds the nucleus flows into the rough endoplasmic reticulum, an organelle studded with ribosomes that manufacture membrane-bound proteins for the rest of the cell.

Judith Stoffer

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organelle, cell

Inside the Cell

Judith Stoffer

Illustration of a sperm, the male reproductive cell.

Judith Stoffer

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Reproduction

Inside the Cell

Judith Stoffer

Animation for the vesicular shuttle model of Golgi transport.

Judith Stoffer

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Vesicle

Inside the Cell

Judith Stoffer

A typical animal cell cycle lasts roughly 24 hours, but depending on the type of cell, it can vary in length from less than 8 hours to more than a year. Most of the variability occurs in Gap1.
Appears in the NIGMS booklet <a href="https://www.nigms.nih.gov/education/Booklets/Inside-the-Cell/Pages/Home.aspx"><em>Inside the Cell</em></a>.

Judith Stoffer

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ITC

Judith Stoffer

Cell mopping up.

Judith Stoffer

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Cartoon

Inside the Cell

Judith Stoffer

Duplicated pair of chromosomes have exchanged material.

Judith Stoffer

(Bulk import) [OCPL Contact: Alisa Machalek] Judith A. Stoffer, MA, CMI
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DNA

Inside the Cell

Judith Stoffer

A cell in metaphase during mitosis: The copied chromosomes align in the middle of the spindle. Mitosis is responsible for growth and development, as well as for replacing injured or worn out cells throughout the body. For simplicity, mitosis is illustrated here with only six chromosomes.

Judith Stoffer

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development, cell cycle

Inside the Cell

Judith Stoffer

A cell in anaphase during mitosis: Chromosomes separate into two genetically identical groups and move to opposite ends of the spindle. Mitosis is responsible for growth and development, as well as for replacing injured or worn out cells throughout the body. For simplicity, mitosis is illustrated here with only six chromosomes.

Judith Stoffer

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development, cell cycle

Inside the Cell

Judith Stoffer

Telophase during mitosis: Nuclear membranes form around each of the two sets of chromosomes, the chromosomes begin to spread out, and the spindle begins to break down. Mitosis is responsible for growth and development, as well as for replacing injured or worn out cells throughout the body. For simplicity, mitosis is illustrated here with only six chromosomes.

Judith Stoffer

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development, cell cycle

Inside the Cell

Judith Stoffer

Reactivating telomerase in our cells does not appear to be a good way to extend the human lifespan. Cancer cells reactivate telomerase.

Judith Stoffer

(Bulk import) [OCPL Contact: Alisa Machalek] Judith A. Stoffer, MA, CMI
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cartoon, telomere

Inside the Cell

Judith Stoffer

A humorous treatment of the concept of a cycling cell.

Judith Stoffer

(Bulk import) [OCPL Contact: Alisa Machalek] Judith A. Stoffer, MA, CMI
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cartoon

Inside the Cell

Judith Stoffer

Mitosis creates cells, and apoptosis kills them. The processes often work together to keep us healthy.

Judith Stoffer

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cartoon

Inside the Cell

Judith Stoffer

The largest human cell (by volume) is the egg. Human eggs are 150 micrometers in diameter and you can just barely see one with a naked eye. In comparison, consider the eggs of chickens...or ostriches!

Judith Stoffer

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size

Inside the Cell

Judith Stoffer

A two-dimensional NMR spectrum of a protein, in this case a 2D 1H-15N HSQC NMR spectrum of a 228 amino acid DNA/RNA-binding protein.

Dr. Xiaolian Gao's laboratory at the University of Houston

Alisa Machalek, Aug 29 2007

Xiaolian Gao, University of Houston

SOL

Dr. Xiaolian Gao's laboratory at the University of Houston

Like a major city, a cell teems with specialized workers that carry out its daily operations--making energy, moving proteins, or helping with other tasks. Researchers took microscopic pictures of thin layers of a cell and then combined them to make this 3-D image featuring color-coded organelles--the cell's "workers." Using this image, scientists can understand how these specialized components fit together in the cell's packed inner world.

Kathryn Howell, University of Colorado Health Sciences Center

organelle

Featured in the August 15, 2006, issue of Biomedical Beat.

Kathryn Howell, University of Colorado Health Sciences Center

As an egg cell develops, a process called polarization controls what parts ultimately become the embryo's head and tail. This picture shows an egg of the fruit fly <em>Drosophila</em>. Red and green mark two types of signaling proteins involved in polarization. Disrupting these signals can scramble the body plan of the embryo, leading to severe developmental disorders.

Wu-Min Deng, Florida State University

development

Featured in the September 19, 2006, issue of Biomedical Beat.

Wu-Min Deng, Florida State University

This web-like structure shows the abnormal accumulation of cholesterol in a mouse brain cell that contains an aberrant protein linked to Huntington's disease, a fatal condition marked by a progressive degeneration of brain nerve cells. While the gene underlying the disease has been identified, little is known about how it leads to such neuronal damage. But the discovery that cholesterol builds up in mouse brain cells expressing the Huntington's protein could offer new clues for understanding the mechanism of the disease in humans.

Cynthia McMurray, Mayo Clinic

microscopy

Featured in the December 19, 2006, issue of Biomedical Beat.

Cynthia McMurray, Mayo Clinic

Like tractor-trailers on a highway, small sacs called vesicles transport substances within cells. This image tracks the motion of vesicles in a living cell. The short red and yellow marks offer information on vesicle movement. The lines spanning the image show overall traffic trends. Typically, the sacs flow from the lower right (blue) to the upper left (red) corner of the picture. Such maps help researchers follow different kinds of cellular processes as they unfold.

Alexey Sharonov and Robin Hochstrasser, University of Pennsylvania

Alexey Sharonov and Robin Hochstrasser also collaborate in a cellular imaging project supported by the NIH Roadmap for Medical Research.

model

Featured in the February 21, 2006, issue of Biomedical Beat.

Alexey Sharonov and Robin Hochstrasser, University of Pennsylvania

Pretty in pink, the enzyme histone deacetylase (HDA6) stands out against a background of blue-tinted DNA in the nucleus of an <em>Arabidopsis</em> plant cell. Here, HDA6 concentrates in the nucleolus (top center), where ribosomal RNA genes reside. The enzyme silences the ribosomal RNA genes from one parent while those from the other parent remain active. This chromosome-specific silencing of ribosomal RNA genes is an unusual phenomenon observed in hybrid plants.

Olga Pontes and Craig Pikaard, Washington University

nucleus

Featured in the June 20, 2006, issue of Biomedical Beat.

Olga Pontes and Craig Pikaard, Washington University

How far and fast an infectious disease spreads across a community depends on many factors, including transportation. These U.S. maps, developed as part of an international study to simulate and analyze disease spread, chart daily commuting patterns. They show where commuters live (top) and where they travel for work (bottom). Green represents the fewest number of people whereas orange, brown, and white depict the most. Such information enables researchers and policymakers to visualize how an outbreak in one area can spread quickly across a geographic region.

David Chrest, RTI International

Courtesy of David Chrest, a geographic information system specialist at RTI International.

model

Featured in the August 15, 2007, issue of Biomedical Beat.

David Chrest, RTI International

Like a map showing heavily traveled roads, this mathematical model of metabolic activity inside an <em>E. coli</em> cell shows the busiest pathway in white. Reaction pathways used less frequently by the cell are marked in red (moderate activity) and green (even less activity). Visualizations like this one may help scientists identify drug targets that block key metabolic pathways in bacteria.

Albert-László Barabási, University of Notre Dame

drug development

Featured in the January 18, 2005, issue of Biomedical Beat.

Albert-László Barabási, University of Notre Dame

What looks like a Native American dream catcher is really a network of social interactions within a community. The red dots along the inner and outer circles represent people, while the different colored lines represent direct contact between them. All connections originate from four individuals near the center of the graph. Modeling social networks can help researchers understand how diseases spread.

Stephen Eubank, University of Virginia Biocomplexity Institute (formerly Virginia Bioinformatics Institute)

infectious disease, public health

 Featured in the July 19, 2005, issue of Biomedical Beat.

Stephen Eubank, University of Virginia Biocomplexity Institute (formerly Virginia Bioinformatics Institute)

Amid a network of blood vessels and star-shaped support cells, neurons in the brain signal each other. The mists of color show the flow of important molecules like glucose and oxygen. This image is a snapshot from a 52-second simulation created by an animation artist. Such visualizations make biological processes more accessible and easier to understand.

Kim Hager, University of California, Los Angeles

Arthur Toga, NCRR

nerve cells

Featured in the February 20, 2007, issue of <em>Biomedical Beat</em>. Featured in <a href="https://www.nigms.nih.gov/education/Booklets/Computing-Life/Pages/Home.aspx"><em>Computing Life</em></a> magazine.

Kim Hager and Neal Prakash, University of California, Los Angeles

Using techniques that took 4 years to design, a team of developmental biologists showed that certain proteins can direct the subdivision of fruit fly and chicken nervous system tissue into the regions depicted here in blue, green, and red. Molecules called bone morphogenetic proteins (BMPs) helped form this fruit fly embryo. While scientists knew that BMPs play a major role earlier in embryonic development, they didn't know how the proteins help organize nervous tissue. The findings suggest that BMPs are part of an evolutionarily conserved mechanism for organizing the nervous system. The National Institute of Neurological Disorders and Stroke also supported this work.

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microscopy, fluorescence

Featured in the October 17, 2006, issue of Biomedical Beat.

Mieko Mizutani and Ethan Bier, University of California, San Diego, and Henk Roelink, University of Washington

Inside the fertilized egg cell of a fruit fly, we see a type of myosin (related to the protein that helps muscles contract) made to glow by attaching a fluorescent protein. After fertilization, the myosin proteins are distributed relatively evenly near the surface of the embryo. The proteins temporarily vanish each time the cells' nuclei--initially buried deep in the cytoplasm--divide. When the multiplying nuclei move to the surface, they shift the myosin, producing darkened holes. The glowing myosin proteins then gather, contract, and start separating the nuclei into their own compartments.

Victoria Foe, University of Washington

fluorescence

This image and a video are featured in the February 22, 2005, issue of Biomedical Beat.

Victoria Foe, University of Washington

Like a watch wrapped around a wrist, a special enzyme encircles the double helix to repair a broken strand of DNA. Without molecules that can mend such breaks, cells can malfunction, die, or become cancerous. Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3493">3493</a>.

Courtesy of Tom Ellenberger, Washington University School of Medicine in St. Louis, and Dave Gohara, Saint Louis University School of Medicine.

Tom Ellenberger

DNA repair

 Featured in the November 21, 2006, issue of Biomedical Beat

Tom Ellenberger, Washington University School of Medicine

This fingertip-shaped group of lights is a microscopic crystal called a quantum dot. About 10,000 times thinner than a sheet of paper, the dot radiates brilliant colors under ultraviolet light. Dots such as this one allow researchers to label and track individual molecules in living cells and may be used for speedy disease diagnosis, DNA testing, and screening for illegal drugs.

Sandra Rosenthal and James McBride, Vanderbilt University, and Stephen Pennycook, Oak Ridge National Laboratory

fluorescence

 Featured in the April 18, 2006, issue of Biomedical Beat.

Sandra Rosenthal and James McBride, Vanderbilt University, and Stephen Pennycook, Oak Ridge National Laboratory

Using a supercomputer to simulate the movement of atoms in a ribosome, researchers looked into the core of this protein-making nanomachine and took snapshots. The picture shows an amino acid (green) being delivered by transfer RNA (yellow) into a corridor (purple) in the ribosome. In the corridor, a series of chemical reactions will string together amino acids to make a protein. The research project, which tracked the movement of more than 2.6 million atoms, was the largest computer simulation of a biological structure to date. The results shed light on the manufacturing of proteins and could aid the search for new antibiotics, which typically work by disabling the ribosomes of bacteria.

Kevin Sanbonmatsu, Los Alamos National Laboratory

model

Featured in the November 15, 2005, issue of Biomedical Beat.

Kevin Sanbonmatsu, Los Alamos National Laboratory

Model of a member from the Tex protein family, which is implicated in transcriptional regulation and highly conserved in eukaryotes and prokaryotes. The structure shows significant homology to a human transcription elongation factor that may regulate multiple steps in mRNA synthesis.

New York Structural GenomiX Research Consortium, PSI

protein structure

New York Structural GenomiX Research Consortium, PSI

NMR solution structure of a plant protein that may function in host defense. This protein was expressed in a convenient and efficient wheat germ cell-free system. Featured as the June 2007 Protein Structure Initiative Structure of the Month.

Center for Eukaryotic Structural Genomics

model

Center for Eukaryotic Structural Genomics

This is the first structure of a protein derived from the metagenomic sequences collected during the Sorcerer II Global Ocean Sampling project. The crystal structure shows a barrel protein with a ferredoxin-like fold and a long chain fatty acid in a deep cleft (shaded red).
Featured as one of the August 2007 Protein Structure Initiative Structures of the Month.

Joint Center for Structural Genomics

model

Joint Center for Structural Genomics

This crystal structure shows a conserved hypothetical protein from <i>Mycobacterium tuberculosis</i>. Only 12 other proteins share its sequence homology, and none has a known function. This structure indicates the protein may play a role in metabolic pathways. Featured as one of the August 2007 Protein Structure Initiative Structures of the Month.

Integrated Center for Structure and Function Innovation

model

Integrated Center for Structure and Function Innovation