• 6074552397843042271731130422717311PublicAssets/6766
    Ribbon diagram of a cefotaxime-CCD-1 complex
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    Ribbon diagram of a cefotaxime-CCD-1 complex

    6766

    CCD-1 is an enzyme produced by the bacterium Clostridioides difficile that helps it resist antibiotics. Using X-ray crystallography, researchers determined the structure of a CCD-1 molecule and a molecule of the antibiotic cefotaxime bound together. The structure revealed that CCD-1 provides extensive hydrogen bonding and stabilization of the antibiotic in the active site, leading to efficient degradation of the antibiotic.

    Related to images 6764, 6765, and 6767.
    Public Note
    Internal NoteRelated to the Journal of Structural Biology paper “The crystal structures of CDD-1, the intrinsic class D β-lactamase from the pathogenic Gram-positive bacterium Clostridioides difficile, and its complex with cefotaxime”: https://www.sciencedirect.com/science/article/abs/pii/S1047847719302023?via%3Dihub Permission email: Good evening Abbey. Clyde Smith got back to me about the images. They are not those published in the paper describing this work (that paper is attached for your reference). We do not see any copyright issues or restrictions. The credit info is found in the paper. The diffraction image was recorded at SSRL. Attached is the word file with some small suggested edits to the captions. Please to not hesitate to be back in touch if you need additional information or clarification. With best regards, Keith
    KeywordsXray, resistance
    SourceKeith Hodgson, Stanford University.
    Date
    Credit LineNichole K. Stewart, University of Notre Dame; Clyde A. Smith, Stanford University; Marta Toth, University of Notre Dame; Anastasiya Stasyuk, Stanford University; and Sergei B. Vakulenko, University of Notre Dame.
    Investigator
    Record TypeIllustration
    Topic Area(s);#Chemistry, Biochemistry, and Pharmacology;#Molecular Structures;#Tools and Techniques;#
    Previous Uses
    StatusActive

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