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  • 6192452024933081221159130812211591PublicAssets/6767CCD-1 is an enzyme produced by the bacterium <em>Clostridioides difficile</em> that helps it resist antibiotics. Using X-ray crystallography, researchers determined the structure of a complex between CCD-1 and the antibiotic cefotaxime (purple, yellow, and blue molecule). The structure revealed that CCD-1 provides extensive hydrogen bonding (shown as dotted lines) and stabilization of the antibiotic in the active site, leading to efficient degradation of the antibiotic. <Br><Br> Related to images <a href="/Pages/DetailPage.aspx?imageID2=6764">6764</a>, <a href="/Pages/DetailPage.aspx?imageID2=6765">6765</a>, and <a href="/Pages/DetailPage.aspx?imageID2=6766">6766</a>.Keith Hodgson, Stanford University.Nichole K. Stewart, University of Notre Dame; Clyde A. Smith, Stanford University; Marta Toth, University of Notre Dame; Anastasiya Stasyuk, Stanford University; and Sergei B. Vakulenko, University of Notre Dame.Illustration

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    Chemistry, Biochemistry, and PharmacologyMolecular StructuresTools and Techniques

    Space-filling model of a cefotaxime-CCD-1 complex

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    CCD-1 is an enzyme produced by the bacterium Clostridioides difficile that helps it resist antibiotics. Using X-ray crystallography, researchers determined the structure of a complex between CCD-1 and the antibiotic cefotaxime (purple, yellow, and blue molecule). The structure revealed that CCD-1 provides extensive hydrogen bonding (shown as dotted lines) and stabilization of the antibiotic in the active site, leading to efficient degradation of the antibiotic.

    Related to images 6764, 6765, and 6766.

    Source

    Keith Hodgson, Stanford University.

    Credit Line

    Nichole K. Stewart, University of Notre Dame; Clyde A. Smith, Stanford University; Marta Toth, University of Notre Dame; Anastasiya Stasyuk, Stanford University; and Sergei B. Vakulenko, University of Notre Dame.

    Record Type

    Illustration

    ID

    6767

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