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    Seeing signaling protein activation in cells 01
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    Seeing signaling protein activation in cells 01

    2451

    Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. In order to fulfill these diverse roles, the timing and location of Cdc42 activation must be tightly controlled. Klaus Hahn and his research group use special dyes designed to report protein conformational changes and interactions, here in living neutrophil cells. Warmer colors in this image indicate higher levels of activation. Cdc42 looks to be activated at cell protrusions.

    Related to images 2452, 2453, and 2454.
    Public Note
    Internal NotePI expressed great willingness to have us use images from his lab's gallery. http://www.med.unc.edu/pharm/faculty/labpages/hahnlab/gallery.html Associated paper: Science. 2004 Sep 10;305(5690):1615-9. Activation of endogenous Cdc42 visualized in living cells. Nalbant P, Hodgson L, Kraynov V, Toutchkine A, Hahn KM.
    Keywords
    SourceKlaus Hahn, University of North Carolina, Chapel Hill Medical School
    Date2008-04-18 00:00:00
    Credit LineKlaus Hahn, University of North Carolina, Chapel Hill Medical School
    InvestigatorKlaus Hahn, CBB
    Record TypePhotograph
    Topic Area(s);#Cells;#Molecular Structures;#
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    StatusActive

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