National Institute of
General Medical Sciences

1508122862557675461412097036229532871PublicAssets/2452Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. In order to fulfill these diverse roles, the timing and location of Cdc42 activation must be tightly controlled. Klaus Hahn and his research group use special dyes designed to report protein conformational changes and interactions, here in living neutrophil cells. Warmer colors in this image indicate higher levels of activation. Cdc42 looks to be activated at cell protrusions. <Br><Br>Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=2451">2451</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=2453">2453</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=2454">2454</a>. Klaus Hahn, University of North Carolina, Chapel Hill Medical SchoolKlaus Hahn, University of North Carolina, Chapel Hill Medical SchoolPhotograph