Detail Page

  • 3143181001741571594710308312131292PublicAssets/3329Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a complex process. Recent research has shown that an actin-polymerizing factor called the Arp2/3 complex is the key component of the actin polymerization engine that drives amoeboid cell motility. ARPC3, a component of the Arp2/3 complex, plays a critical role in actin nucleation. In this photo, the ARPC3-/- fibroblast cells were fixed and stained with Alexa 546 phalloidin for F-actin (red), Arp2 (green), and DAPI to visualize the nucleus (blue). Arp2, a subunit of the Arp2/3 complex, is absent in the filopodi-like structures based leading edge of ARPC3-/- fibroblasts cells. Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3328">3328</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3330">3330</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3331">3331</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3332">3332</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3333">3333</a>.Rong Li and Praveen Suraneni, Stowers Institute for Medical ResearchRong Li and Praveen Suraneni, Stowers Institute for Medical ResearchPhotograph

    Topic Tags:

    Cells

    Spreading Cells- 02

    Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a complex process. Recent research has shown that an actin-polymerizing factor called the Arp2/3 complex is the key component of the actin polymerization engine that drives amoeboid cell motility. ARPC3, a component of the Arp2/3 complex, plays a critical role in actin nucleation. In this photo, the ARPC3-/- fibroblast cells were fixed and stained with Alexa 546 phalloidin for F-actin (red), Arp2 (green), and DAPI to visualize the nucleus (blue). Arp2, a subunit of the Arp2/3 complex, is absent in the filopodi-like structures based leading edge of ARPC3-/- fibroblasts cells. Related to images 3328, 3330, 3331, 3332, and 3333.

    Source

    Rong Li and Praveen Suraneni, Stowers Institute for Medical Research

    Credit Line

    Rong Li and Praveen Suraneni, Stowers Institute for Medical Research

    Record Type

    Photograph

    ID

    3329

My Images/Videos