Detail Page

  • 70272040943735136024963308316134445PublicAssets/3597A study published in March 2012 used cryo-electron microscopy to determine the structure of the DNA replication origin recognition complex (ORC), a semi-circular, protein complex (yellow) that recognizes and binds DNA to start the replication process. The ORC appears to wrap around and bend approximately 70 base pairs of double stranded DNA (red and blue). Also shown is the protein Cdc6 (green), which is also involved in the initiation of DNA replication. Related to video <a href="/Pages/DetailPage.aspx?imageID2=3307">3307</a> that shows the structure from different angles. From a Brookhaven National Laboratory <a href="https://www.bnl.gov/newsroom/news.php?a=111391" target="_blank">news release</a>, "Study Reveals How Protein Machinery Binds and Wraps DNA to Start Replication."Huilin Li, Brookhaven National LaboratoryHuilin Li, Brookhaven National Laboratory, and Bruce Stillman, Cold Spring Harbor LaboratoryIllustration

    Topic Tags:

    GenesMolecular StructuresTools and Techniques

    DNA replication origin recognition complex (ORC)

    View EntryAdd to My Images

    A study published in March 2012 used cryo-electron microscopy to determine the structure of the DNA replication origin recognition complex (ORC), a semi-circular, protein complex (yellow) that recognizes and binds DNA to start the replication process. The ORC appears to wrap around and bend approximately 70 base pairs of double stranded DNA (red and blue). Also shown is the protein Cdc6 (green), which is also involved in the initiation of DNA replication. Related to video 3307 that shows the structure from different angles. From a Brookhaven National Laboratory news release, "Study Reveals How Protein Machinery Binds and Wraps DNA to Start Replication."

    Source

    Huilin Li, Brookhaven National Laboratory

    Credit Line

    Huilin Li, Brookhaven National Laboratory, and Bruce Stillman, Cold Spring Harbor Laboratory

    Record Type

    Illustration

    ID

    3597

My Images/Videos