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  • 21576741PublicAssets/7022Individual cells are color-coded based on their identity and signaling activity using a protein circuit technology developed by the Coyle Lab. Just as a radio allows you to listen to an individual frequency, this technology allows researchers to tune into the specific “radio station” of each cell through genetically encoded proteins from a bacterial system called MinDE. The proteins generate an oscillating fluorescent signal that transmits information about cell shape, state, and identity that can be decoded using digital signal processing tools originally designed for telecommunications. The approach allows researchers to look at the dynamics of a single cell in the presence of many other cells. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7021">7021</a>. Scott Coyle, University of Wisconsin-Madison.Rohith Rajasekaran, Scott Coyle’s lab, University of Wisconsin-Madison.Video

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    CellsTools and Techniques

    Single-cell “radios”

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    Individual cells are color-coded based on their identity and signaling activity using a protein circuit technology developed by the Coyle Lab. Just as a radio allows you to listen to an individual frequency, this technology allows researchers to tune into the specific “radio station” of each cell through genetically encoded proteins from a bacterial system called MinDE. The proteins generate an oscillating fluorescent signal that transmits information about cell shape, state, and identity that can be decoded using digital signal processing tools originally designed for telecommunications. The approach allows researchers to look at the dynamics of a single cell in the presence of many other cells.

    Related to image 7021.

    Source

    Scott Coyle, University of Wisconsin-Madison.

    Credit Line

    Rohith Rajasekaran, Scott Coyle’s lab, University of Wisconsin-Madison.

    Record Type

    Video

    ID

    7022

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