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  • 872224PublicAssets/6570Two highly stressed osteosarcoma cells are shown with a set of green droplet-like structures followed by a second set of magenta droplets. These droplets are composed of fluorescently labeled stress-response proteins, either G3BP or UBQLN2 (Ubiquilin-2). Each protein is undergoing a fascinating process, called phase separation, in which a non-membrane bound compartment of the cytoplasm emerges with a distinct environment from the surrounding cytoplasm. Subsequently, the proteins fuse with like proteins to form larger droplets, in much the same way that raindrops merge on a car’s windshield. Julia F. Riley and Carlos A. Castañeda, Syracuse University Julia F. Riley, Heidi Hehnly, Sandra Hewett, and Carlos A. Castañeda, Syracuse University. Video

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    Cells

    Stress Response in Cells

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    Two highly stressed osteosarcoma cells are shown with a set of green droplet-like structures followed by a second set of magenta droplets. These droplets are composed of fluorescently labeled stress-response proteins, either G3BP or UBQLN2 (Ubiquilin-2). Each protein is undergoing a fascinating process, called phase separation, in which a non-membrane bound compartment of the cytoplasm emerges with a distinct environment from the surrounding cytoplasm. Subsequently, the proteins fuse with like proteins to form larger droplets, in much the same way that raindrops merge on a car’s windshield.

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    Julia F. Riley and Carlos A. Castañeda, Syracuse University

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    Julia F. Riley, Heidi Hehnly, Sandra Hewett, and Carlos A. Castañeda, Syracuse University.

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    Video

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    6570

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