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  • 7467461923963733731595430828476464PublicAssets/6488This illustration shows, in simplified terms, how the CRISPR-Cas9 system can be used as a gene-editing tool. The CRISPR system has two components joined together: a finely tuned targeting device (a small strand of RNA programmed to look for a specific DNA sequence) and a strong cutting device (an enzyme called Cas9 that can cut through a double strand of DNA). This frame (4 out of 4) shows a repaired DNA strand with new genetic material that researchers can introduce, which the cell automatically incorporates into the gap when it repairs the broken DNA. <Br><Br>For an explanation and overview of the CRISPR-Cas9 system, see the <a href=" http://www.ibiology.org/ibiomagazine/jennifer-doudna-genome-engineering-with-crispr-cas9-birth-of-a-breakthrough-technology.html">iBiology video</a>, and find the full <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7036">CRIPSR illustration here</a>.National Institute of General Medical Sciences.National Institute of General Medical Sciences.Illustration

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    This illustration shows, in simplified terms, how the CRISPR-Cas9 system can be used as a gene-editing tool. The CRISPR system has two components joined together: a finely tuned targeting device (a small strand of RNA programmed to look for a specific DNA sequence) and a strong cutting device (an enzyme called Cas9 that can cut through a double strand of DNA). This frame (4 out of 4) shows a repaired DNA strand with new genetic material that researchers can introduce, which the cell automatically incorporates into the gap when it repairs the broken DNA.

    For an explanation and overview of the CRISPR-Cas9 system, see the iBiology video, and find the full CRIPSR illustration here.

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    National Institute of General Medical Sciences.

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    National Institute of General Medical Sciences.

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    Illustration

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    6488

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