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  • 24002400212891612001200396457576576108554PublicAssets/3756Dengue virus is a mosquito-borne illness that infects millions of people in the tropics and subtropics each year. Like many viruses, dengue is enclosed by a protective membrane. The proteins that span this membrane play an important role in the life cycle of the virus. Scientists used cryo-EM to determine the structure of a dengue virus at a 3.5-angstrom resolution to reveal how the membrane proteins undergo major structural changes as the virus matures and infects a host. For more on cryo-EM see the blog post <a href="https://biobeat.nigms.nih.gov/2016/02/cryo-electron-microscopy-reveals-molecules-in-ever-greater-detail/">Cryo-Electron Microscopy Reveals Molecules in Ever Greater Detail.</a> You can watch a rotating view of the dengue virus surface structure <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3748">in video 3748.</a>Hong Zhou, UCLAHong Zhou, UCLAIllustration

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    Molecular StructuresTools and Techniques

    Protective membrane and membrane proteins of the dengue virus visualized with cryo-EM

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    Dengue virus is a mosquito-borne illness that infects millions of people in the tropics and subtropics each year. Like many viruses, dengue is enclosed by a protective membrane. The proteins that span this membrane play an important role in the life cycle of the virus. Scientists used cryo-EM to determine the structure of a dengue virus at a 3.5-angstrom resolution to reveal how the membrane proteins undergo major structural changes as the virus matures and infects a host. For more on cryo-EM see the blog post Cryo-Electron Microscopy Reveals Molecules in Ever Greater Detail. You can watch a rotating view of the dengue virus surface structure in video 3748.

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    Hong Zhou, UCLA

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    Hong Zhou, UCLA

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    Illustration

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    3756

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