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  • 2880285231991561440142621352469068472701PublicAssets/3330Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a complex process. Recent research has shown that an actin-polymerizing factor called the Arp2/3 complex is the key component of the actin polymerization engine that drives amoeboid cell motility. ARPC3, a component of the Arp2/3 complex, plays a critical role in actin nucleation. In this photo, the ARPC3+/+ fibroblast cells were fixed and stained with Alexa 546 phalloidin for F-actin (red), mDia1 (green), and DAPI to visualize the nucleus (blue). mDia1 is localized at the lamellipodia of ARPC3+/+ fibroblast cells. Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3328">3328</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3329">3329</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3331">3331</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3332">3332</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=3333">3333</a>.Rong Li and Praveen Suraneni, Stowers Institute for Medical ResearchRong Li and Praveen Suraneni, Stowers Institute for Medical ResearchPhotograph

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    Cells

    mDia1 antibody staining-01

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    Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a complex process. Recent research has shown that an actin-polymerizing factor called the Arp2/3 complex is the key component of the actin polymerization engine that drives amoeboid cell motility. ARPC3, a component of the Arp2/3 complex, plays a critical role in actin nucleation. In this photo, the ARPC3+/+ fibroblast cells were fixed and stained with Alexa 546 phalloidin for F-actin (red), mDia1 (green), and DAPI to visualize the nucleus (blue). mDia1 is localized at the lamellipodia of ARPC3+/+ fibroblast cells. Related to images 3328, 3329, 3331, 3332, and 3333.

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    Rong Li and Praveen Suraneni, Stowers Institute for Medical Research

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    Rong Li and Praveen Suraneni, Stowers Institute for Medical Research

    Record Type

    Photograph

    ID

    3330

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