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    Mouse brain slice showing nerve cells
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    Mouse brain slice showing nerve cells

    6901

    A 20-µm thick section of mouse midbrain. The nerve cells are transparent and weren’t stained. Instead, the color is generated by interaction of white polarized light with the molecules in the cells and indicates their orientation.

    The image was obtained with a polychromatic polarizing microscope that shows the polychromatic birefringent image with hue corresponding to the slow axis orientation. More information about the microscopy that produced this image can be found in the Scientific Reports paper “Polychromatic Polarization Microscope: Bringing Colors to a Colorless World” by Shribak.
    Public NoteGroups of colored lines.
    Internal NoteYes, I give my permission to add the three movies (crane fly, circular lamellipodia, and baby squids) and the mouse brain slice image to your image and video gallery. Thank you, Michael Michael Shribak, Ph.D. Senior Scientist Marine Biological Laboratory/ University of Chicago 7 MBL St Woods Hole, MA 02543
    Keywordsblue, red, green, pink, neurons
    SourceMichael Shribak, Marine Biological Laboratory/University of Chicago.
    Date
    Credit LineMichael Shribak, Marine Biological Laboratory/University of Chicago, and Timothy Balmer, Arizona State University.
    InvestigatorPolychromatic polarization microscope: bringing colors to a colorless world. Shribak M. Sci Rep. 2015 Nov 27;5:17340. Mouse midbrain section image obtained with new polychromatic polarizing microscope (https://www.nature.com/articles/srep17340), which allows directly see the polychromatic birefringent image with hue corresponding to the slow axis orientation. The image shows a coronal view of 20-µm thick section of the brain, which has been sliced down a vertical axis. No staining was applied to the transparent specimen. Nerve cells appear in the real colors that reveal orientation of the molecules. Let’s credit for the mouse midbrain image to me and Tim Balmer. Tim kindly provided the specimen.
    Record TypePhotograph
    Topic Area(s);#Cells;#Molecular Structures;#Tools and Techniques;#
    Previous Useshttps://directorsblog.nih.gov/2017/04/27/snapshots-of-life-neurons-in-a-new-light/
    StatusActive

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Low10 KB 7/13/2022 4:07 PMBigler, Abbey (NIH/NIGMS) [C]
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Medium10 KB 6/30/2022 8:15 AMCrowley, Rachel (NIH/NIGMS) [E]
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