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    Neutrophil-like cells migrating in a microfluidic chip

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    Neutrophil-like cells migrating in a microfluidic chip


    Neutrophil-like cells (blue) in a microfluidic chip preferentially migrating toward LTB4 over fMLP. A neutrophil is a type of white blood cell that is part of the immune system and helps the body fight infection. Both LTB4 and fMLP are molecules involved in immune response. Microfluidic chips are small devices containing microscopic channels, and they are used in a range of applications, from basic research on cells to pathogen detection. The scale bar in this video is 500μm.
    Public NoteMany cells moving through narrow channels.
    Internal NoteFrom: Jones, Caroline Sent: Monday, March 28, 2022 11:20 AM To: Bigler, Abbey (NIH/NIGMS) [C] Subject: [EXTERNAL] Re: NIGMS Blog Request

    Dear Abbey, That would be great to add my cell migration video to the NIGMS Image and Video Gallery. It isn’t under any copyright restrictions. I hope you have a nice week. Best regards, Caroline

    Caroline N. Jones, Ph.D. Assistant Professor of Bioengineering Adjunct Assistant Professor of Surgery (UT Southwestern) University of Texas at Dallas Bioengineering and Sciences Building, Office 12.806 Richardson, TX 75080 Caroline.Jones@UTDallas.edu; 972.883.7279
    KeywordsChemotaxis, microfluidics, cell migration, immunology, sepsis
    SourceCaroline Jones, University of Texas at Dallas.
    Credit LineBrittany Boribong and Caroline Jones, Virginia Technical Institute.
    InvestigatorNeutrophils migrating in my microfluidic competitive chemotaxis-chip (μC3). This specific experiment is dHL-60 (neutrophil-like) cells stimulated with super-low dose LPS migrating toward fMLP and LTB4 within the μC3. dHL-60 cells (blue) stimulated with super low-dose LPS [1 ng/mL LPS] preferentially migrating toward LTB4 over fMLP (green) within the μC3. Scale Bar = 500μm.
    Record TypeVideo
    Topic Area(s);#Cells;#Tools and Techniques;#
    Previous UsesUsed in the Biomedical Beat blog post, “Career Conversations: Q&A with Immunoengineer Caroline Jones.”

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High3903 KB 4/4/2022 10:32 AMBigler, Abbey (NIH/NIGMS) [C]
Thumbnail2309 KB 4/1/2022 4:11 PMBigler, Abbey (NIH/NIGMS) [C]

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