• 6192452024933081221159130812211591PublicAssets/6767
    Space-filling model of a cefotaxime-CCD-1 complex
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    Space-filling model of a cefotaxime-CCD-1 complex


    CCD-1 is an enzyme produced by the bacterium Clostridioides difficile that helps it resist antibiotics. Using X-ray crystallography, researchers determined the structure of a complex between CCD-1 and the antibiotic cefotaxime (purple, yellow, and blue molecule). The structure revealed that CCD-1 provides extensive hydrogen bonding (shown as dotted lines) and stabilization of the antibiotic in the active site, leading to efficient degradation of the antibiotic.

    Related to images 6764, 6765, and 6766.
    Public Note
    Internal NoteRelated to the Journal of Structural Biology paper “The crystal structures of CDD-1, the intrinsic class D β-lactamase from the pathogenic Gram-positive bacterium Clostridioides difficile, and its complex with cefotaxime”: https://www.sciencedirect.com/science/article/abs/pii/S1047847719302023?via%3Dihub
    KeywordsXray, resistance
    SourceKeith Hodgson, Stanford University.
    Credit LineNichole K. Stewart, University of Notre Dame; Clyde A. Smith, Stanford University; Marta Toth, University of Notre Dame; Anastasiya Stasyuk, Stanford University; and Sergei B. Vakulenko, University of Notre Dame.
    Record TypeIllustration
    Topic Area(s);#Chemistry, Biochemistry, and Pharmacology;#Molecular Structures;#Tools and Techniques;#
    Previous UsesIncluded in the Pathways interactive “Step Into an Imaging Lab”: https://www.scholastic.com/pathways/techlab/index.html

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Low12 KB 9/21/2021 4:49 PMDolan, Lauren (NIH/NIGMS) [C]
Thumbnail198 KB 6/23/2021 11:22 AMDolan, Lauren (NIH/NIGMS) [C]
High198 KB 6/23/2021 11:22 AMDolan, Lauren (NIH/NIGMS) [C]
Medium12 KB 6/21/2021 1:48 PMDolan, Lauren (NIH/NIGMS) [C]

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