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    CRISPR surveillance complex
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    CRISPR surveillance complex

    6352

    This image shows how the CRISPR surveillance complex is disabled by two copies of anti-CRISPR protein AcrF1 (red) and one AcrF2 (light green). These anti-CRISPRs block access to the CRISPR RNA (green tube) preventing the surveillance complex from scanning and targeting invading viral DNA for destruction.
    Public Note
    Internal Note
    KeywordsCRISPR Anti-CRISPR viral DNA gene editing
    SourceNRAMM National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher
    Date
    Credit LineNRAMM National Resource for Automated Molecular Microscopy
    InvestigatorSee: Chowdhury, S., J. Carter, M. F. Rollins, S. M. Golden, R. N. Jackson, C. Hoffmann, L. Nosaka, J. Bondy-Denomy, K. L. Maxwell, A. R. Davidson, E. R. Fischer, G. C. Lander, and B. Wiedenheft. 2017. Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex. Cell 169:47-57 e11.
    Record TypeIllustration
    Topic Area(s);#Cells;#Molecular Structures;#Tools and Techniques;#
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    StatusActive

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CRISPR 2 of 2 NRAMM.jpg
  
High197 KB 11/29/2017 11:59 AMVarkala, Venkat (NIH/NIGMS) [C]
CRISPR 2 of 2 NRAMM_M.jpg
  
Medium44 KB 11/29/2017 11:59 AMVarkala, Venkat (NIH/NIGMS) [C]
CRISPR 2 of 2 NRAMM_S.jpg
  
Low10 KB 11/29/2017 11:59 AMVarkala, Venkat (NIH/NIGMS) [C]
CRISPR 2 of 2 NRAMM_thumbnail.jpg
  
Thumbnail3 KB 11/29/2017 11:59 AMVarkala, Venkat (NIH/NIGMS) [C]

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