• 24029841816120149236130838255297PublicAssets/5766
    A chromosome goes missing in anaphase
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    A chromosome goes missing in anaphase


    Anaphase is the critical step during mitosis when sister chromosomes are disjoined and directed to opposite spindle poles, ensuring equal distribution of the genome during cell division. In this image, one pair of sister chromosomes at the top was lost and failed to divide after chemical inhibition of polo-like kinase 1. This image depicts chromosomes (blue) separating away from the spindle mid-zone (red). Kinetochores (green) highlight impaired movement of some chromosomes away from the mid-zone or the failure of sister chromatid separation (top). Scientists are interested in detailing the signaling events that are disrupted to produce this effect. The image is a volume projection of multiple deconvolved z-planes acquired with a Nikon widefield fluorescence microscope.

    This image was chosen as a winner of the 2016 NIH-funded research image call. The research that led to this image was funded by NIGMS.

    Related to image 5765.
    Public Note
    Internal NoteThe image is from a Flickr album of the NIH Image Gallery: https://www.flickr.com/photos/nihgov/26898997643/in/album-72157666897233564/
    Keywordsmitosis cell cycle chromosome spindle cell division DNA
    Date2016-07-21 00:00:00
    Credit LineRobert Lera and Mark Burkard, University of Wisconsin-Madison
    InvestigatorMark Burkard, University of Wisconsin-Madison
    Record TypePhotograph
    Topic Area(s);#Cells;#Genes;#
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Low55 KB 3/28/2019 3:21 PMConstantinides, Stephen (NIH/NIGMS) [C]
Thumbnail55 KB 3/28/2019 3:20 PMConstantinides, Stephen (NIH/NIGMS) [C]
Medium3 KB 7/21/2016 2:36 PMVarkala, Venkat (NIH/NIGMS) [C]
High41 KB 7/21/2016 2:36 PMVarkala, Venkat (NIH/NIGMS) [C]

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