• 12008005596156004006689628819237042PublicAssets/3755
    Cryo-EM reveals how the HIV capsid attaches to a human protein to evade immune detection
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    Cryo-EM reveals how the HIV capsid attaches to a human protein to evade immune detection

    3755

    The illustration shows the capsid of human immunodeficiency virus (HIV) whose molecular features were resolved with cryo-electron microscopy (cryo-EM). On the left, the HIV capsid is "naked," a state in which it would be easily detected by and removed from cells. However, as shown on the right, when the viral capsid binds to and is covered with a host protein, called cyclophilin A (shown in red), it evades detection and enters and invades the human cell to use it to establish an infection. To learn more about how cyclophilin A helps HIV infect cells and how scientists used cryo-EM to find out the mechanism by which the HIV capsid attaches to cyclophilin A, see this news release by the University of Illinois. A study reporting these findings was published in the journal Nature Communications.
    Public Note
    Internal NoteResearchers gave permission for public use: From: jrperillaj@gmail.com [jrperillaj@gmail.com] on behalf of Juan R. Perilla [jperilla@illinois.edu] Sent: Monday, March 07, 2016 11:16 AM To: Spiering, Martin (NIH/NIGMS) [C] Cc: Schulten, Klaus J Subject: Re: Inclusion of HIV-cyclophilin A image in NIGMS image gallery Dear Martin, I would be happy if you include my figure in NIH's image repository. You can download a high version of the figure using the following link: https://www.dropbox.com/s/y12v3za0t8ezk2s/CaCypA-sidebyside.tif?dl=0 Best regards, ~ Juan On Mon, Mar 7, 2016 at 9:58 AM, Spiering, Martin (NIH/NIGMS) [C] wrote: Dear Dr. Schulten, I am a writer and editor with the Office of Communication and Public Liaison at the National Institute of General Medical Sciences. I am reaching out to you because we just noticed one of your very striking illustrations (see attached) depicting HIV covered in cyclophilin A featured in this recent release (https://news.illinois.edu/blog/view/6367/335013) about your exciting structural biology work on HIV. We would be very grateful if we could include your artwork in our Image Gallery on the NIGMS website (at https://images.nigms.nih.gov/). As you may know, images and videos in the NIGMS Image Gallery highlight NIGMS-funded work and are made available to the public for educational uses, provided that users credit the creator, i.e., you, for this work. Would you let us feature your work in our image gallery in this way? If so, could you send us a high-resolution version of your illustration (if available)? Please let me know if you have any questions. I look forward to hearing from you. Thank you, Martin J Spiering, PhD, ELS Writer & Editor (contractor) OCPL, National Institutes of Health/NIGMS martin.spiering@nih.gov
    Keywords
    SourceJuan R. Perilla, University of Illinois at Urbana-Champaign
    Date
    Credit LineJuan R. Perilla, Klaus Schulten and the Theoretical and Computational Biophysics Group
    InvestigatorKlaus Schulten, University of Illinois at Urbana-Champaign
    Record TypeIllustration
    Topic Area(s);#Molecular Structures;#Tools and Techniques;#
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    StatusActive

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HIV capsid square crop.jpg
  
Thumbnail152 KB 10/13/2016 12:57 PMMachalek, Alisa (NIH/NIAMS) [E]
HIV_Cyclophilin_A.jpg
  
High547 KB 6/3/2016 3:40 PMaamishral2 (NIH/NIGMS) [C]
HIV_Cyclophilin_A_L.jpg
  
Low37 KB 6/3/2016 3:40 PMaamishral2 (NIH/NIGMS) [C]
HIV_Cyclophilin_A_M.jpg
  
Medium66 KB 6/3/2016 3:40 PMaamishral2 (NIH/NIGMS) [C]

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