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    Transmission electron microscopy of myelinated axons with ECM between the axons
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    Transmission electron microscopy of myelinated axons with ECM between the axons

    3736

    The extracellular matrix (ECM) is most prevalent in connective tissues but also is present between the stems (axons) of nerve cells, as shown here. Blue-colored nerve cell axons are surrounded by brown-colored, myelin-supplying Schwann cells, which act like insulation around an electrical wire to help speed the transmission of electric nerve impulses down the axon. The ECM is pale pink. The tiny brown spots within it are the collagen fibers that are part of the ECM.
    Public Note
    Internal NoteResearchers supplied image & gave permission for public use: From: Tom Deerinck [mailto:deerinck@ncmir.ucsd.edu] Sent: Friday, August 14, 2015 4:52 PM To: Carlson, Emily (NIH/NIGMS) [E] Subject: Re: ECM images from NCMIR? Hi Emily, I have attached 8 assorted images showing ECM. Use one or all. The first 6 are: ?Courtesy Thomas Deerinck and Mark Ellisman, NCMIR The last 2 are ?Courtesy Varda Lev-Ram Ellisman and Mark Ellisman, NCMIR 1: Collagen fibers (main component of ECM). SEM 2: Myelinating axons with ECM between the myelinating cells. TEM. 3: Bundle of peripheral myelinated nerve axonal ECM. SEM. 4: Coronary artery wall with elastin rich ECM pseudocolored light brown. TEM 5: Soleus muscle ECM on the muscle surface. Blood vessel is pseudocolored red. SEM 6: Cross-section of node of Ranvier with surrounding ECM pseudocolored cyan. TEM 7: Cortex neuronal ECM labeled with Wisteria Floribunda Agglutinin (WFA)-fluorescein. The labeling shows perineuronal nets (PNN) which are a specialized form of ECM in the brain. Imaged by confocal microscopy. 8: Cortex neuronal ECM labeled with Wisteria Floribunda Agglutinin (WFA)-fluorescein. The labeling shows perineuronal nets (PNN) which are a specialized form of ECM in the brain. Imaged by confocal microscopy. Best, Tom D. PS I would love to see the finished product!
    KeywordsEM, TEM, neurons
    SourceTom Deerinck, National Center for Microscopy and Imaging Research (NCMIR)
    Date2016-01-29 00:00:00
    Credit LineTom Deerinck and Mark Ellisman, NCMIR
    InvestigatorMark Ellisman, NCMIR
    Record TypePhotograph
    Topic Area(s);#Cells;#Tools and Techniques;#
    Previous Uses
    StatusActive

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