• 29682226222564114721104385670735551147523PublicAssets/3720
    Cas4 nuclease protein structure
    View Entry

    Large-Resolution Image
    2968 x 2226 pixels
    10 × 7 inches (300 dpi)

    Medium-Resolution Image
    1472 x 1104 pixels
    10 × 7 inches (150 dpi)

    Low-Resolution Image
    735 x 551 pixels
    10 × 8 inches (72 dpi)

    Cas4 nuclease protein structure


    This wreath represents the molecular structure of a protein, Cas4, which is part of a system, known as CRISPR, that bacteria use to protect themselves against viral invaders. The green ribbons show the protein's structure, and the red balls show the location of iron and sulfur molecules important for the protein's function. Scientists harnessed Cas9, a different protein in the bacterial CRISPR system, to create a gene-editing tool known as CRISPR-Cas9. Using this tool, researchers are able to study a range of cellular processes and human diseases more easily, cheaply and precisely. In December, 2015, Science magazine recognized the CRISPR-Cas9 gene-editing tool as the "breakthrough of the year." Read more about Cas4 in the December 2015 Biomedical Beat post A Holiday-Themed Image Collection.
    Public Note
    Internal Note
    SourceFred Dyda, NIDDK
    Credit Linemolecular model by Fred Dyda, National Institute of Diabetes and Digestive and Kidney Diseases, PDB entry number 4ic1
    Investigatorsee PDB entry 4ic1
    Record TypeIllustration
    Topic Area(s);#Chemistry, Biochemistry, and Pharmacology;#Genes;#Molecular Structures;#
    Previous Uses

    View All Properties
    Edit Properties
Medium377 KB 6/3/2016 3:39 PMaamishral2 (NIH/NIGMS) [C]
Thumbnail42 KB 6/3/2016 3:39 PMaamishral2 (NIH/NIGMS) [C]
High2174 KB 6/3/2016 3:39 PMaamishral2 (NIH/NIGMS) [C]
Low145 KB 6/3/2016 3:39 PMaamishral2 (NIH/NIGMS) [C]

 Add New Version

Note: Uploading a version which already exists will overwrite the existing version with the uploaded file.
* Uploaded thumbnails wider than 120 pixels will be reduced.