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    Cytochrome structure with anticancer drug
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    Cytochrome structure with anticancer drug


    This image shows the structure of the CYP17A1 enzyme (ribbons colored from blue N-terminus to red C-terminus), with the associated heme colored black. The prostate cancer drug abiraterone is colored gray. Cytochrome P450 enzymes bind to and metabolize a variety of chemicals, including drugs. Cytochrome P450 17A1 also helps create steroid hormones. Emily Scott's lab is studying how CYP17A1 could be selectively inhibited to treat prostate cancer. She and graduate student Natasha DeVore elucidated the structure shown using X-ray crystallography. Dr. Scott created the image (both white bg and transparent bg) for the NIGMS image gallery. See the "Medium-Resolution Image" for a PNG version of the image that is transparent.
    Public Note
    Internal NotePERMISSION FOR IMAGE GALLERY -----Original Message----- From: Scott, Emily E [mailto:eescott@ku.edu] Sent: Thursday, April 26, 2012 10:30 PM To: Machalek, Alisa Zapp (NIH/NIGMS) [E] Subject: Re: seeking high res CYP17A1 Alisa, Yes, please be my guest to add it to your image gallery for general usage with acknowledgment. My pleasure. Cheers, Emily -- Emily E. Scott, Ph.D. Associate Professor Dept. of Medicinal Chemistry University of Kansas 1251 Wescoe Hall Dr. Lawrence, KS 66045 phone: (785) 864-5559 fax: (785) 864-5326 http://www.medchem.ku.edu/faculty_scott.shtml On 4/26/12 1:32 PM, "Machalek, Alisa Zapp (NIH/NIGMS) [E]" wrote: Thanks for your speedy response, Emily. This will work fine. Since it's a large file and is free of copyright restrictions, would we be able to add it to the NIGMS image gallery (http://images.nigms.nih.gov/ ), where it will be available for anyone else to use for non-commercial purposes, provided they acknowledge you? Would we also be able to use the image in other printed and online publications from my office? I'll send you the Findings write-up to check for accuracy in the next day or two. > Thanks again, Alisa >_________________________ >>-----Original Message----- >From: Scott, Emily E [mailto:eescott@ku.edu] >Sent: Thursday, April 26, 2012 2:02 PM >To: Machalek, Alisa Zapp (NIH/NIGMS) [E] >Cc: DeVore, Natasha Mary >Subject: Re: seeking high res CYP17A1 > Dear Alisa, We'd be very glad to provide an image for your use in Findings.Perhaps the attached would do? It is an image free of copyright restrictions that shows the CYP17A1 enzyme ribbons colored from blue N-terminus to red C-terminus) with the heme as black sticks and the prostate cancer drug abiraterone in grey sticks. The background is transparent for maximal flexibility in composition. This png file is a rather large and can be scaled as you like in terms of resolution and size.
    SourceEmily Scott, University of Kansas
    Date2012-05-09 00:00:00
    Credit LineEmily Scott, University of Kansas
    InvestigatorEmily Scott, University of Kansas
    Record TypeIllustration
    Topic Area(s);#Chemistry, Biochemistry, and Pharmacology;#Molecular Structures;#Tools and Techniques;#
    Previous UsesAlisa requested this in spring 2012 for use in Findings.

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