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    Dynamin structure
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    Dynamin structure

    2744

    When a molecule arrives at a cell's outer membrane, the membrane creates a pouch around the molecule that protrudes inward. Directed by a protein called dynamin, the pouch then gets pinched off to form a vesicle that carries the molecule to the right place inside the cell. To better understand how dynamin performs its vital pouch-pinching role, researchers determined its structure. Based on the structure, they proposed that a dynamin "collar" at the pouch's base twists ever tighter until the vesicle pops free. Because cells absorb many drugs through vesicles, the discovery could lead to new drug delivery methods.
    Public Note
    Internal Notehttp://publications.nigms.nih.gov/biobeat/10-05-19/index.html#3
    KeywordsGTPase, plasma membrane, cell membrane, endocytosis, protein structure
    SourceJosh Chappie, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
    Date2010-06-10 00:00:00
    Credit LineJosh Chappie, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
    InvestigatorSandra Schmid, The Scripps Research Institute
    Record TypeIllustration
    Topic Area(s);#Cells;#
    Previous UsesBiomedical Beat: May 19, 2010
    StatusActive

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Thumbnail53 KB 3/12/2019 12:12 PMConstantinides, Stephen (NIH/NIGMS) [C]
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Low53 KB 3/12/2019 12:11 PMConstantinides, Stephen (NIH/NIGMS) [C]
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Medium53 KB 3/12/2019 12:11 PMConstantinides, Stephen (NIH/NIGMS) [C]
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High53 KB 3/12/2019 12:11 PMConstantinides, Stephen (NIH/NIGMS) [C]

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