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View Entry | Histone deacetylases7001| The human genome contains much of the information needed for every cell in the body to function. However, different types of cells often need different types of information. Access to DNA is controlled, in part, by how tightly it’s wrapped around proteins called histones to form nucleosomes.
The complex shown here, from yeast cells (PDB entry 6Z6P), includes several histone deacetylase (HDAC) enzymes (green and blue) bound to a nucleosome (histone proteins in red; DNA in yellow). The yeast HDAC enzymes are similar to the human enzymes. Two enzymes form a V-shaped clamp (green) that holds the other others, a dimer of the Hda1 enzymes (blue). In this assembly, Hda1 is activated and positioned to remove acetyl groups from histone tails.
| | Public Note | | A flower-shaped complex. Yellow helices (DNA) wrap around an orange core (histones). Blue and green enzymes sit below them. | | | Internal Note | | : From: Amy Wu
Sent: Thursday, February 1, 2024 4:20 PM
To: Bigler, Abbey (NIH/NIGMS) [C] ; Crowley, Rachel (NIH/NIGMS) [E]
Cc: Christine Zardecki
Subject: [EXTERNAL] RCSB PDB Content for the NIGMS Image and Video Gallery
Hi!
I hope all is well. Attached is a Google Folder link + Word document with all the requested images and information.
Link: https://drive.google.com/drive/folders/17GbO9ddzOn0UAifMihHDo6qAQdIQgE4r?usp=drive_link
Please feel free to email me with any questions.
Sincerely,
Amy
Funding Source: RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.
| | | Keywords | | | | | Source | | Amy Wu and Christine Zardecki, RCSB Protein Data Bank. | | | Date | | | | | Credit Line | | Jessica Damanski, Paloma Munguía Salazar, Mihika Shah, Rajiv Snape, David S. Goodsell, Stephen K. Burley, and the RCSB Protein Data Bank. | | | Investigator | | Yeast Histone Deacetylases (HDAC) complex (green and blue) bound to a nucleosome (histone proteins in red; DNA in yellow). The complex shown here, from yeast cells (PDB entry 6Z6P), includes several Hda enzymes similar to human HDAC enzymes. Hda2 and Hda3 are non-catalytic and form a V-shaped clamp that holds a Hda1-Hda1’ dimer. In this assembly, Hda1 is activated and positioned to remove acetyl groups from histone tails. | | | Record Type | | Illustration | | | Topic Area(s) | | ;#Genes;#Molecular Structures;# | | | Previous Uses | | | | | Status | | Active | |
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