• 1479126456472207396329067236931622146PublicAssets/7000
    Plastic-eating enzymes
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    Plastic-eating enzymes

    7000

    PETase enzyme degrades polyester plastic (polyethylene terephthalate, or PET) into monohydroxyethyl terephthalate (MHET). Then, MHETase enzyme degrades MHET into its constituents ethylene glycol (EG) and terephthalic acid (TPA).

    Find these in the RCSB Protein Data Bank: PET hydrolase (PDB entry 5XH3) and MHETase (PDB entry 6QGA).
    Public NoteA diagram showing the steps of plastic degradation. A long change of PET plastic polymer is converted into the smaller molecule MHET which is further broken down into two small molecules, EG and TPA. A purple blob labeled PETase and a larger blob labeled MHETase both have a yellow spot in them.
    Internal Note: From: Amy Wu Sent: Thursday, February 1, 2024 4:20 PM To: Bigler, Abbey (NIH/NIGMS) [C] ; Crowley, Rachel (NIH/NIGMS) [E] Cc: Christine Zardecki Subject: [EXTERNAL] RCSB PDB Content for the NIGMS Image and Video Gallery Hi! I hope all is well. Attached is a Google Folder link + Word document with all the requested images and information. Link: https://drive.google.com/drive/folders/17GbO9ddzOn0UAifMihHDo6qAQdIQgE4r?usp=drive_link Please feel free to email me with any questions. Sincerely, Amy Funding Source: RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.
    Keywords
    SourceAmy Wu and Christine Zardecki, RCSB Protein Data Bank.
    Date
    Credit LineDavid S. Goodsell and the RCSB Protein Data Bank.
    Investigator
    Record TypeIllustration
    Topic Area(s);#Chemistry, Biochemistry, and Pharmacology;#Molecular Structures;#
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    StatusActive

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