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    HIV enzyme
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    HIV enzyme

    6999

    These images model the molecular structures of three enzymes with critical roles in the life cycle of the human immunodeficiency virus (HIV). At the top, reverse transcriptase (orange) creates a DNA copy (yellow) of the virus's RNA genome (blue). In the middle image, integrase (magenta) inserts this DNA copy in the DNA genome (green) of the infected cell. At the bottom, much later in the viral life cycle, protease (turquoise) chops up a chain of HIV structural protein (purple) to generate the building blocks for making new viruses. See these enzymes in action on PDB 101’s video A Molecular View of HIV Therapy.
    Public NoteThree pictures of large protein blobs with helices winding through them.
    Internal NoteFrom: Amy Wu Sent: Thursday, February 1, 2024 4:20 PM To: Bigler, Abbey (NIH/NIGMS) [C] ; Crowley, Rachel (NIH/NIGMS) [E] Cc: Christine Zardecki Subject: [EXTERNAL] RCSB PDB Content for the NIGMS Image and Video Gallery Hi! I hope all is well. Attached is a Google Folder link + Word document with all the requested images and information. Link: https://drive.google.com/drive/folders/17GbO9ddzOn0UAifMihHDo6qAQdIQgE4r?usp=drive_link Please feel free to email me with any questions. Sincerely, Amy Funding Source: RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.
    Keywords
    SourceAmy Wu and Christine Zardecki, RCSB Protein Data Bank.
    Date
    Credit LineMaria Voigt, David S. Goodsell, and the RCSB Protein Data Bank.
    Investigator
    Record TypeIllustration
    Topic Area(s);#Genes;#Injury and Illness;#Molecular Structures;#
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    StatusActive

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