• 19291906110655769649528699248147623051PublicAssets/6991
    SARS-CoV-2 nucleocapsid dimer
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    SARS-CoV-2 nucleocapsid dimer

    6991

    In SARS-CoV-2, the virus that causes COVID-19, nucleocapsid is a complex molecule with many functional parts. One section folds into an RNA-binding domain, with a groove that grips a short segment of the viral genomic RNA. Another section folds into a dimerization domain that brings two nucleocapsid molecules together. The rest of the protein is intrinsically disordered, forming tails at each end of the protein chain and a flexible linker that connects the two structured domains. These disordered regions assist with RNA binding and orchestrate association of nucleocapsid dimers into larger assemblies that package the RNA in the small space inside virions. Nucleocapsid is in magenta and purple, and short RNA strands are in yellow.

    Find these in the RCSB Protein Data Bank: RNA-binding domain (PDB entry 7ACT) and Dimerization domain (PDB entry 6WJI).
    Public NoteThree clumps of pink and purple connected by curved lines.
    Internal Note From: Amy Wu Sent: Thursday, February 1, 2024 4:20 PM To: Bigler, Abbey (NIH/NIGMS) [C] ; Crowley, Rachel (NIH/NIGMS) [E] Cc: Christine Zardecki Subject: [EXTERNAL] RCSB PDB Content for the NIGMS Image and Video Gallery Hi! I hope all is well. Attached is a Google Folder link + Word document with all the requested images and information. Link: https://drive.google.com/drive/folders/17GbO9ddzOn0UAifMihHDo6qAQdIQgE4r?usp=drive_link Please feel free to email me with any questions. Sincerely, Amy Funding Source: RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.
    KeywordsCOVID
    SourceAmy Wu and Christine Zardecki, RCSB Protein Data Bank.
    Date
    Credit LineDavid S. Goodsell and the RCSB Protein Data Bank.
    InvestigatorStructurally-ordered domains are depicted from the atomic structures and disordered regions are shown schematically. Nucleocapsid is in magenta and purple, and short RNA strands are in yellow.
    Record TypeIllustration
    Topic Area(s);#Injury and Illness;#Molecular Structures;#
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    StatusActive

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