• 25443046PublicAssets/6805
    Staphylococcus aureus aggregating upon contact with synovial fluid
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    Staphylococcus aureus aggregating upon contact with synovial fluid

    6805

    Staphylococcus aureus bacteria (green) grouping together upon contact with synovial fluid—a viscous substance found in joints. The formation of groups can help protect the bacteria from immune system defenses and from antibiotics, increasing the likelihood of an infection. This video is a 1-hour time lapse and was captured using a confocal laser scanning microscope.

    More information about the research that produced this video can be found in the Journal of Bacteriology paper "In Vitro Staphylococcal Aggregate Morphology and Protection from Antibiotics Are Dependent on Distinct Mechanisms Arising from Postsurgical Joint Components and Fluid Motion" by Staats et al.

    Related to images 6803 and 6804.
    Public Note
    Internal NoteAlt text: Spherical bacteria joining together to form larger and larger groups. Instrument used: Fluoview Fv10i Laser Scanning Microscope, Olympus. Technique: Fluorescence Time-lapse Imaging used for image collection; 1 hour of imaging with the 60x objective. Dear Abbey, I would be happy to share. We do have some really nice movies of Staph. aureus aggregating in synovial fluid as well as electron micrographs of staph. on orthopaedic surfaces. It is unpublished but we are in the process of submitting. Paul. Paul Stoodley, PhD. Director, Campus Microscopy and Imaging Facility (CMIF) Professor, Departments of Microbial Infection and Immunity and Orthopedics Infectious Diseases Institute, The Ohio State University, 716 Biomedical Research Tower, 460 West 12th Avenue, Columbus OH 43210.
    Keywordsbacterium
    SourcePaul Stoodley, The Ohio State University.
    Date
    Credit LineAmelia Staats and Paul Stoodley, The Ohio State University; Alex Horswill, University of Colorado School of Medicine.
    Investigator
    Record TypeVideo
    Topic Area(s);#Cells;#Injury and Illness;#Tools and Techniques;#
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    StatusActive

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