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    Full-length serotonin receptor (ion channel)
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    Full-length serotonin receptor (ion channel)

    6579

    A 3D reconstruction, created using cryo-electron microscopy, of an ion channel known as the full-length serotonin receptor in complex with the antinausea drug granisetron (orange). Ion channels are proteins in cell membranes that help regulate many processes.
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    Internal NoteIon channels help regulate many processes such as motor function and pain transmission, and medications often target them. Sudha Chakrapani’s lab identified a structure of an ion channel, known as the full-length serotonin receptor, that binds to a group of drugs that can manage nausea caused by cancer therapies. Understanding how these medications interact with the full-length serotonin receptor could help researchers further improve their designs.
    Keywords
    SourceSudha Chakrapani, Case Western Reserve University School of Medicine.
    Date
    Credit LineSudha Chakrapani, Case Western Reserve University School of Medicine.
    Investigator
    Record TypeIllustration
    Topic Area(s);#Molecular Structures;#
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    StatusActive

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