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    Bacterial ribosome assembly
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    Bacterial ribosome assembly

    6578

    3D reconstructions of two stages in the assembly of the bacterial ribosome created from time-resolved cryo-electron microscopy images. Ribosomes translate genetic instructions into proteins.
    Public Note
    Internal NoteHere are two reconstructions showing two stages in the assembly of the bacterial ribosome from its two subunits (the small and the large subunit). The left image shows the small subunit bound to the tRNA (orange/green) that carries the first building block of the protein to be made. It is also bound to the genetic message and two factors called IF1 (red) and IF2 (purple/carmine), which are important helpers in the assembly. In less than one fiftieth second after adding the large subunit (not shown here), the factor IF1 has left (image on the right), giving the go-ahead for the next step of assembly in which IF2 leaves as well. In the end the fully assembled ribosome is ready to translate the genetic message into protein.
    Keywords
    SourceJoachim Frank, Columbia University.
    Date
    Credit LineJoachim Frank, Columbia University.
    Investigator
    Record TypeIllustration
    Topic Area(s);#Molecular Structures;#
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    StatusActive

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