• 120010468073456005237107730026117858PublicAssets/6577
    Transient receptor potential channel TRPV5
    Active
    View Entry

    Large-Resolution Image
    1200 x 1046 pixels
    4 × 3 inches (300 dpi)
    0.77Mb

    Medium-Resolution Image
    600 x 523 pixels
    4 × 3 inches (150 dpi)
    69.4kb

    Low-Resolution Image
    300 x 261 pixels
    4 × 4 inches (72 dpi)
    17.4kb

    Transient receptor potential channel TRPV5

    6577

    A 3D reconstruction of a transient receptor potential channel called TRPV5 that was created based on cryo-electron microscopy images. TRPV5 is primarily found in kidney cells and is essential for reabsorbing calcium into the blood.
    Public Note
    Internal NoteIf TRPV5 malfunctions, the amount of calcium in urine greatly increases, possibly leading to kidney stones. Dr. Moiseenkova-Bell’s research in this area has provided molecular details of how TRPV5 is modulated and identified a molecule that can inhibit the channel. Currently, her laboratory is using cryo-EM to determine TRPV5 channel structures in conditions that better mimic those found in the body, including the presence of regulatory proteins. She hopes that a better understanding of how this channel works will inform the search for drugs that effectively treat kidney stones.
    Keywords
    SourceVera Moiseenkova-Bell, University of Pennsylvania.
    Date
    Credit LineVera Moiseenkova-Bell, University of Pennsylvania.
    Investigator
    Record TypeIllustration
    Topic Area(s);#Molecular Structures;#
    Previous Uses
    StatusActive

    View All Properties
    Edit Properties

Add New Version

Note: Uploading a version which already exists will overwrite the existing version with the uploaded file.
* Uploaded thumbnails wider than 120 pixels will be reduced.