• 12165596PublicAssets/3764
    Movie of the 19S proteasome subunit processing a protein substrate
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    Movie of the 19S proteasome subunit processing a protein substrate

    3764

    The proteasome is a critical multiprotein complex in the cell that breaks down and recycles proteins that have become damaged or are no longer needed. This movie shows how a protein substrate (red) is bound through its ubiquitin chain (blue) to one of the ubiquitin receptors of the proteasome (Rpn10, yellow). The substrate's flexible engagement region then gets engaged by the AAA+ motor of the proteasome (cyan), which initiates mechanical pulling, unfolding and movement of the protein into the proteasome's interior for cleavage into shorter protein pieces called peptides. During movement of the substrate, its ubiquitin modification gets cleaved off by the deubiquitinase Rpn11 (green), which sits directly above the entrance to the AAA+ motor pore and acts as a gatekeeper to ensure efficient ubiquitin removal, a prerequisite for fast protein breakdown by the 26S proteasome. Related to image 3763.
    Public Note
    Internal NoteResearcher gave permission for public use: Dear Martin, Sorry about the delay in getting back to you. Yes, I give you permission to use my illustration and video. I attached the narrative with a few minor edits. It looks good. Thanks, Andy ------------------------------- Andy Martin Investigator, Howard Hughes Medical Institute Associate Professor, Department of Molecular & Cell Biology; QB3 Institute University of California at Berkeley 570 Stanley Hall Berkeley CA 94720-3220 USA
    Keywords
    SourceAndreas Martin, HHMI
    Date2016-03-22 00:00:00
    Credit LineAndreas Martin, HHMI
    InvestigatorAndreas Martin, HHMI
    Record TypeVideo
    Topic Area(s);#Molecular Structures;#
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    StatusActive

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