• 240022139503661200110727475157653195392PublicAssets/3740
    Transmission electron microscopy showing cross-section of the node of Ranvier
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    Transmission electron microscopy showing cross-section of the node of Ranvier

    3740

    Nodes of Ranvier are short gaps in the myelin sheath surrounding myelinated nerve cells (axons). Myelin insulates axons, and the node of Ranvier is where the axon is exposed to the extracellular environment, allowing for the transmission of action potentials at these nodes via ion flows between the inside and outside of the axon. The image shows a cross-section through the node, with the surrounding extracellular matrix encasing and supporting the axon shown in cyan.
    Public Note
    Internal NoteResearchers supplied image & gave permission for public use: From: Tom Deerinck [mailto:deerinck@ncmir.ucsd.edu] Sent: Friday, August 14, 2015 4:52 PM To: Carlson, Emily (NIH/NIGMS) [E] Subject: Re: ECM images from NCMIR? Hi Emily, I have attached 8 assorted images showing ECM. Use one or all. The first 6 are: ?Courtesy Thomas Deerinck and Mark Ellisman, NCMIR The last 2 are ?Courtesy Varda Lev-Ram Ellisman and Mark Ellisman, NCMIR 1: Collagen fibers (main component of ECM). SEM 2: Myelinating axons with ECM between the myelinating cells. TEM. 3: Bundle of peripheral myelinated nerve axonal ECM. SEM. 4: Coronary artery wall with elastin rich ECM pseudocolored light brown. TEM 5: Soleus muscle ECM on the muscle surface. Blood vessel is pseudocolored red. SEM 6: Cross-section of node of Ranvier with surrounding ECM pseudocolored cyan. TEM 7: Cortex neuronal ECM labeled with Wisteria Floribunda Agglutinin (WFA)-fluorescein. The labeling shows perineuronal nets (PNN) which are a specialized form of ECM in the brain. Imaged by confocal microscopy. 8: Cortex neuronal ECM labeled with Wisteria Floribunda Agglutinin (WFA)-fluorescein. The labeling shows perineuronal nets (PNN) which are a specialized form of ECM in the brain. Imaged by confocal microscopy. Best, Tom D. PS I would love to see the finished product!
    KeywordsEM, TEM, neurons
    SourceTom Deerinck, National Center for Microscopy and Imaging Research (NCMIR)
    Date2016-01-29 00:00:00
    Credit LineMark Ellisman and Tom Deerinck, National Center for Microscopy and Imaging Research
    InvestigatorMark Ellisman, NCMIR
    Record TypePhotograph
    Topic Area(s);#Cells;#Tools and Techniques;#
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    StatusActive

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