• 240017971242021120089932886457643194043PublicAssets/3739
    Scanning electron microscopy of the ECM on the surface of a calf muscle
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    Scanning electron microscopy of the ECM on the surface of a calf muscle

    3739

    This image shows the extracellular matrix (ECM) on the surface of a soleus (lower calf) muscle in light brown and blood vessels in pink. Near the bottom of the photo, a vessel is opened up to reveal red blood cells. Scientists know less about the ECM in muscle than in other tissues, but it's increasingly clear that the ECM is critical to muscle function, and disruption of the ECM has been associated with many muscle disorders. The ECM in muscles stores and releases growth factors, suggesting that it might play a role in cellular communication.
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    Internal NoteResearchers supplied image & gave permission for public use: From: Tom Deerinck [mailto:deerinck@ncmir.ucsd.edu] Sent: Friday, August 14, 2015 4:52 PM To: Carlson, Emily (NIH/NIGMS) [E] Subject: Re: ECM images from NCMIR? Hi Emily, I have attached 8 assorted images showing ECM. Use one or all. The first 6 are: ?Courtesy Thomas Deerinck and Mark Ellisman, NCMIR The last 2 are ?Courtesy Varda Lev-Ram Ellisman and Mark Ellisman, NCMIR 1: Collagen fibers (main component of ECM). SEM 2: Myelinating axons with ECM between the myelinating cells. TEM. 3: Bundle of peripheral myelinated nerve axonal ECM. SEM. 4: Coronary artery wall with elastin rich ECM pseudocolored light brown. TEM 5: Soleus muscle ECM on the muscle surface. Blood vessel is pseudocolored red. SEM 6: Cross-section of node of Ranvier with surrounding ECM pseudocolored cyan. TEM 7: Cortex neuronal ECM labeled with Wisteria Floribunda Agglutinin (WFA)-fluorescein. The labeling shows perineuronal nets (PNN) which are a specialized form of ECM in the brain. Imaged by confocal microscopy. 8: Cortex neuronal ECM labeled with Wisteria Floribunda Agglutinin (WFA)-fluorescein. The labeling shows perineuronal nets (PNN) which are a specialized form of ECM in the brain. Imaged by confocal microscopy. Best, Tom D. PS I would love to see the finished product!
    KeywordsEM, SEM
    SourceTom Deerinck, National Center for Microscopy and Imaging Research (NCMIR)
    Date2016-01-29 00:00:00
    Credit LineMark Ellisman and Tom Deerinck, National Center for Microscopy and Imaging Research
    InvestigatorMark Ellisman, NCMIR
    Record TypePhotograph
    Topic Area(s);#Cells;#Tools and Techniques;#
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    StatusActive

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