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    A bundle of myelinated peripheral nerve cells (axons)
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    A bundle of myelinated peripheral nerve cells (axons)

    3737

    The extracellular matrix (ECM) is most prevalent in connective tissues but also is present between the stems (axons) of nerve cells. The axons of nerve cells are surrounded by the ECM encasing myelin-supplying Schwann cells, which insulate the axons to help speed the transmission of electric nerve impulses along the axons.
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    Internal NoteResearchers supplied image & gave permission for public use: From: Tom Deerinck [mailto:deerinck@ncmir.ucsd.edu] Sent: Friday, August 14, 2015 4:52 PM To: Carlson, Emily (NIH/NIGMS) [E] Subject: Re: ECM images from NCMIR? Hi Emily, I have attached 8 assorted images showing ECM. Use one or all. The first 6 are: ?Courtesy Thomas Deerinck and Mark Ellisman, NCMIR The last 2 are ?Courtesy Varda Lev-Ram Ellisman and Mark Ellisman, NCMIR 1: Collagen fibers (main component of ECM). SEM 2: Myelinating axons with ECM between the myelinating cells. TEM. 3: Bundle of peripheral myelinated nerve axonal ECM. SEM. 4: Coronary artery wall with elastin rich ECM pseudocolored light brown. TEM 5: Soleus muscle ECM on the muscle surface. Blood vessel is pseudocolored red. SEM 6: Cross-section of node of Ranvier with surrounding ECM pseudocolored cyan. TEM 7: Cortex neuronal ECM labeled with Wisteria Floribunda Agglutinin (WFA)-fluorescein. The labeling shows perineuronal nets (PNN) which are a specialized form of ECM in the brain. Imaged by confocal microscopy. 8: Cortex neuronal ECM labeled with Wisteria Floribunda Agglutinin (WFA)-fluorescein. The labeling shows perineuronal nets (PNN) which are a specialized form of ECM in the brain. Imaged by confocal microscopy. Best, Tom D. PS I would love to see the finished product!
    Keywordsneurons
    SourceTom Deerinck, National Center for Microscopy and Imaging Research (NCMIR)
    Date2016-01-29 00:00:00
    Credit LineMark Ellisman and Tom Deerinck, National Center for Microscopy and Imaging Research
    InvestigatorMark Ellisman, NCMIR
    Record TypePhotograph
    Topic Area(s);#Cells;#
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    StatusActive

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