• 2400188115062931200941317773576451111169PublicAssets/3735
    Scanning electron microscopy of collagen fibers
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    Scanning electron microscopy of collagen fibers

    3735

    This image shows collagen, a fibrous protein that's the main component of the extracellular matrix (ECM). Collagen is a strong, ropelike molecule that forms stretch-resistant fibers. The most abundant protein in our bodies, collagen accounts for about a quarter of our total protein mass. Among its many functions is giving strength to our tendons, ligaments and bones and providing scaffolding for skin wounds to heal. There are about 20 different types of collagen in our bodies, each adapted to the needs of specific tissues
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    Internal NoteResearchers supplied images & gave permission for public use: From: Tom Deerinck [mailto:deerinck@ncmir.ucsd.edu] Sent: Friday, August 14, 2015 4:52 PM To: Carlson, Emily (NIH/NIGMS) [E] Subject: Re: ECM images from NCMIR? Hi Emily, I have attached 8 assorted images showing ECM. Use one or all. The first 6 are: ?Courtesy Thomas Deerinck and Mark Ellisman, NCMIR The last 2 are ?Courtesy Varda Lev-Ram Ellisman and Mark Ellisman, NCMIR 1: Collagen fibers (main component of ECM). SEM 2: Myelinating axons with ECM between the myelinating cells. TEM. 3: Bundle of peripheral myelinated nerve axonal ECM. SEM. 4: Coronary artery wall with elastin rich ECM pseudocolored light brown. TEM 5: Soleus muscle ECM on the muscle surface. Blood vessel is pseudocolored red. SEM 6: Cross-section of node of Ranvier with surrounding ECM pseudocolored cyan. TEM 7: Cortex neuronal ECM labeled with Wisteria Floribunda Agglutinin (WFA)-fluorescein. The labeling shows perineuronal nets (PNN) which are a specialized form of ECM in the brain. Imaged by confocal microscopy. 8: Cortex neuronal ECM labeled with Wisteria Floribunda Agglutinin (WFA)-fluorescein. The labeling shows perineuronal nets (PNN) which are a specialized form of ECM in the brain. Imaged by confocal microscopy. Best, Tom D. PS I would love to see the finished product!
    KeywordsEM, SEM
    SourceTom Deerinck, National Center for Microscopy and Imaging Research (NCMIR)
    Date2016-01-29 00:00:00
    Credit LineTom Deerinck and Mark Ellisman, NCMIR
    InvestigatorMark Ellisman, NCMIR
    Record TypePhotograph
    Topic Area(s);#Cells;#Tools and Techniques;#
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    StatusActive

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