• 8768876877414393000300097942114401440311499PublicAssets/3598
    Developing zebrafish fin
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    Developing zebrafish fin

    3598

    Originally from the waters of India, Nepal, and neighboring countries, zebrafish can now be found swimming in science labs (and home aquariums) throughout the world. This fish is a favorite study subject for scientists interested in how genes guide the early stages of prenatal development (including the developing fin shown here) and in the effects of environmental contamination on embryos.

    In this image, green fluorescent protein (GFP) is expressed where the gene sox9b is expressed. Collagen (red) marks the fin rays, and DNA, stained with a dye called DAPI, is in blue. sox9b plays many important roles during development, including the building of the heart and brain, and is also necessary for skeletal development. At the University of Wisconsin, researchers have found that exposure to contaminants that bind the aryl-hydrocarbon receptor results in the downregulation of sox9b. Loss of sox9b severely disrupts development in zebrafish and causes a life-threatening disorder called campomelic dysplasia (CD) in humans. CD is characterized by cardiovascular, neural, and skeletal defects. By studying the roles of genes such as sox9b in zebrafish, scientists hope to better understand normal development in humans as well as how to treat developmental disorders and diseases.

    This image was part of the Life: Magnified exhibit that ran from June 3, 2014, to January 21, 2015, at Dulles International Airport.
    Public Note
    Internal NoteNIEHS funding featured in Dulles 2014 exhibit A larger version of this (10,000 pixels square, 286 MB) is in the shared OCPL folder/DULLES airport images
    Keywordscolorful, life magnified, structure
    SourceJessica Plavicki
    Date
    Credit LineJessica Plavicki, University of Wisconsin, Madison
    Investigator
    Record TypePhotograph
    Topic Area(s);#Cells;#Genes;#Tools and Techniques;#
    Previous Uses
    StatusActive

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