• 2743360012515081371180026448968590066642PublicAssets/3550
    Protein clumping in zinc-deficient yeast cells
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    Protein clumping in zinc-deficient yeast cells

    3550

    The green spots in this image are clumps of protein inside yeast cells that are deficient in both zinc and a protein called Tsa1 that prevents clumping. Protein clumping plays a role in many diseases, including Parkinson's and Alzheimer's, where proteins clump together in the brain. Zinc deficiency within a cell can cause proteins to mis-fold and eventually clump together. Normally, in yeast, Tsa1 codes for so-called "chaperone proteins" which help proteins in stressed cells, such as those with a zinc deficiency, fold correctly. The research behind this image was published in 2013 in the Journal of Biological Chemistry.
    Public Note
    Internal Note> > Hi Sharon > > > > That would be great- glad you liked the picture! > > > > Dave > > > > On 12/4/13 10:57 AM, "Reynolds, Sharon (NIH/NIGMS) [C]" > > wrote: > > > > Dear Dr. Eide, > > > > Back in October, we saw your institution's press release on your > > Journal of Biological Chemistry paper > > (http://www.news.wisc.edu/22170). Since the study had some NIGMS funding, we put a link to it on our news page: > > http://www.nigms.nih.gov/News/Results/Pages/default.aspx. The NIGMS > > Office of Communications and Public Liaison also manages an Image and > > Video Gallery: http://images.nigms.nih.gov/. The image of the yeast > > cells used in your press release really caught our eye--would you give > > us permission to put it (or a similar one without copyright > > restrictions if that one was used in the paper) in the public domain > > in the gallery? We would of course credit you and your lab. > > > > Best regards, > > Sharon
    Keywordssickness, minerals
    SourceColin MacDiarmid and David Eide, University of Wisconsin--Madison
    Date2013-12-10 00:00:00
    Credit LineColin MacDiarmid and David Eide/Journal of Biological Chemistry
    InvestigatorColin MacDiarmid and David Eide, University of Wisconsin--Madiso
    Record TypePhotograph
    Topic Area(s);#Cells;#Injury and Illness;#
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    StatusActive

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