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View Entry | Calcium uptake during ATP production in mitochondria3449| Living primary mouse embryonic fibroblasts. Mitochondria (green) stained with the mitochondrial membrane potential indicator, rhodamine 123. Nuclei (blue) are stained with DAPI.
Caption from a November 26, 2012 news release from U Penn (Penn Medicine). | | Public Note | | | | | Internal Note | | From: Kevin Foskett [mailto:foskett@mail.med.upenn.edu]
Sent: Wednesday, May 15, 2013 11:14 AM
To: Kreeger, Karen
Subject: Re: Permission from NIGMS to use another image
it was not in the Nature Cell Bio paper.
On May 15, 2013, at 10:32 AM, "Kreeger, Karen" wrote:
Great. I have copied Kevin and Lili on this to make sure. They have both said yes for the permission request.
Lili, Kevin, the image wasn?t in the Nature paper, correct?
Cheers, Karen
From: Machalek, Alisa Zapp (NIH/NIGMS) [E] [mailto:MachaleA@nigms.nih.gov]
Sent: Wednesday, May 15, 2013 10:15 AM
To: Kreeger, Karen
Subject: RE: Permission from NIGMS to use another image
Thanks! So, just to be sure?the image in the release was not published in the Nature Cell Bio paper and is free of any copyright restrictions, right?
From: Kreeger, Karen [mailto:Karen.Kreeger@uphs.upenn.edu]
Sent: Wednesday, May 15, 2013 10:04 AM
To: Machalek, Alisa Zapp (NIH/NIGMS) [E]
Subject: FW: Permission from NIGMS to use another image
Hi again! See below for permission from Lili Guo.
Cheers, KK
-----Original Message-----
From: Lili Guo [mailto:guolili@mail.med.upenn.edu]
Sent: Wednesday, May 15, 2013 9:57 AM
To: Kreeger, Karen
Cc: Kevin Foskett
Subject: Re: Permission from NIGMS to use another image
It will be my pleasure. -Lili
----- Original Message -----
From: "Karen Kreeger"
To: "Kevin Foskett" , "Lili Guo"
Sent: Wednesday, May 15, 2013 9:37:33 AM
Subject: Permission from NIGMS to use another image
Hello Lili and Kevin:
Alisa Zapp Machalek, who covers science writing, editing and education for NIGMS would like permission to include the image below from the Nature Cell Biology release (http://www.uphs.upenn.edu/news/News_Releases/2012/11/energy/ ) in their public domain image library. Would this be OK with you? | | | Keywords | | | | | Source | | Lili Guo, Perelman School of Medicine, University of Pennsylvania | | | Date | | 2013-05-16 00:00:00 | | | Credit Line | | Lili Guo, Perelman School of Medicine, University of Pennsylvania | | | Investigator | | | | | Record Type | | Photograph | | | Topic Area(s) | | ;#Cells;#Molecular Structures;# | | | Previous Uses | | Ca2+ flux across the inner mitochondrial membrane regulates cell bioenergetics, cytoplasmic Ca2+ signals and activation of cell death pathways. Ca2+ uptake from the cytoplasm is driven by the electrochemical gradient generated during ATP production, mediated by a Ca2+ ion channel called the mitochondrial Ca2+ uniporter. Molecular components of the uniporter include MCU, the Ca2+ conducting pore, and MICU1, a MCU regulator that limits Ca2+ permeation through MCU at rest. MCUR1 is as an essential third component of the uniporter complex. In the absence of MCUR1, mitochondrial Ca2+ uptake is markedly reduced, with adverse cellular consequences, including compromised cellular bioenergetics, diminished oxidative phosphorylation and activation of autophagy. | | | Status | | Active | |
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