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View Entry | Transcription factor Sox17 controls embryonic development of certain internal organs3440| During embryonic development, transcription factors (proteins that regulate gene expression) govern the differentiation of cells into separate tissues and organs. Researchers at Cincinnati Children's Hospital Medical Center used mice to study the development of certain internal organs, including the liver, pancreas, duodenum (beginning part of the small intestine), gall bladder and bile ducts. They discovered that transcription factor Sox17 guides some cells to develop into liver cells and others to become part of the pancreas or biliary system (gall bladder, bile ducts and associated structures). The separation of these two distinct cell types (liver versus pancreas/biliary system) is complete by embryonic day 8.5 in mice. The transcription factors PDX1 and Hes1 are also known to be involved in embryonic development of the pancreas and biliary system.
This image shows mouse cells at embryonic day 10.5. The green areas show cells that will develop into the pancreas and/or duodenum(PDX1 is labeled green). The blue area near the bottom will become the gall bladder and the connecting tubes (common duct and cystic duct) that attach the gall bladder to the liver and pancreas (Sox17 is labeled blue). The transcription factor Hes1 is labeled red.
The image was not published. A similar image (different plane of the section) was published in:
Sox17 Regulates Organ Lineage Segregation of Ventral Foregut Progenitor Cells
Jason R. Spence, Alex W. Lange, Suh-Chin J. Lin, Klaus H. Kaestner, Andrew M. Lowy, Injune Kim, Jeffrey A. Whitsett and James M. Wells, Developmental Cell, Volume 17, Issue 1, 62-74, 21 July 2009. doi:10.1016/j.devcel.2009.05.012 | | Public Note | | | | | Internal Note | | From: Wells, James (Jim) [mailto:James.Wells@cchmc.org]
Sent: Wednesday, November 28, 2012 10:34 AM
To: Machalek, Alisa Zapp (NIH/NIGMS) [E]
Subject: Re: NIH requesting permission to use image of your work
Hi Alisa,
I sent some images but they didn't seem to go thru.
This attached is associated with the Dev Cell paper you reference. However, the image you sent me was from a Nature 2011 paper.
Let me know which paper you want images for.
Jim
From: "Machalek, Alisa Zapp (NIH/NIGMS) [E]"
Date: Wed, 28 Nov 2012 01:44:31 +0000
To: James Wells
Cc: "Machalek, Alisa Zapp (NIH/NIGMS) [E]"
Subject: NIH requesting permission to use image of your work
Dr. Wells,
A couple years ago, Erin Fults wrote about your work (Spence, et al, Developmental Cell 2009) for Findings magazine and we included the image below. We?re now producing a poster using images from Findings. May we include this image on the poster? If so, and if it?s not too much trouble, can you send me this image in the highest resolution (pixel-wise) version you have? I?d also be happy with another high-resolution/large image that looks essentially the same in terms of color and composition.
Would we also have permission to include this image (or any others you have) in the NIGMS image gallery (http://images.nigms.nih.gov/)? Images in this gallery are in the public domain and we encourage people to use them only for non-commercial purposes and to provide an image credit. If we can include this or other images, how would you like the credit(s) to appear? James M. Wells, Cincinnati Children's Hospital Medical Center? Or should credit go instead--or in addition--to someone else on your research team?
Thanks much?and keep up the cool work! If you alert me when you have a major paper accepted for publication, I can work with your institution?s news office to publicize the work.
Best,
Alisa | | | Keywords | | | | | Source | | James M. Wells, Cincinnati Children's Hospital Medical Center | | | Date | | 2013-03-13 00:00:00 | | | Credit Line | | Jason Spence and James M. Wells, Cincinnati Children's Hospital Medical Center | | | Investigator | | | | | Record Type | | Photograph | | | Topic Area(s) | | ;#Cells;# | | | Previous Uses | | | | | Status | | Active | |
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