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    Mouse mammary cells lacking anti-cancer protein
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    Mouse mammary cells lacking anti-cancer protein

    3432

    Shortly after a pregnant woman gives birth, her breasts start to secrete milk. This process is triggered by hormonal and genetic cues, including the protein Elf5. Scientists discovered that Elf5 also has another job--it staves off cancer. Early in the development of breast cancer, human breast cells often lose Elf5 proteins. Cells without Elf5 change shape and spread readily--properties associated with metastasis. This image shows cells in the mouse mammary gland that are lacking Elf5, leading to the overproduction of other proteins (red) that increase the likelihood of metastasis.
    Public Note
    Internal NoteImage comes from work that was published in the Nature Cell Biology, November 2012, Volume 14 No. 11 pp 1113-1231 and a similar image was published on the cover of that issue.
    KeywordsMammal
    SourceNature Cell Biology, November 2012, Volume 14 No 11 pp1113-1231
    Date2012-11-15 00:00:00
    Credit LineRumela Chakrabarti, Princeton University
    Investigator
    Record TypePhotograph
    Topic Area(s);#Cells;#
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    StatusActive

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