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View Entry | Enzyme transition states3429| The molecule on the left is an electrostatic potential map of the van der Waals surface of the transition state for human purine nucleoside phosphorylase. The colors indicate the electron density at any position of the molecule. Red indicates electron-rich regions with negative charge and blue indicates electron-poor regions with positive charge. The molecule on the right is called DADMe-ImmH. It is a chemically stable analogue of the transition state on the left. It binds to the enzyme millions of times tighter than the substrate. This inhibitor is in human clinical trials for treating patients with gout.
This image appears in Figure 4, Schramm, V.L. (2011) Annu. Rev. Biochem. 80:703-732. | | Public Note | | | | | Internal Note | | The publisher and Dr. Schramm have given permission for its inclusion in this gallery.
From: Rita Chang [mailto:rchang@annualreviews.org]
Sent: Thursday, October 04, 2012 4:20 PM
To: Machalek, Alisa Zapp (NIH/NIGMS) [E]
Subject: RE: image from 2011 Schramm paper
Correct.
From: Machalek, Alisa Zapp (NIH/NIGMS) [E] [mailto:MachaleA@nigms.nih.gov]
Sent: Thursday, October 04, 2012 1:12 PM
To: Rita Chang
Subject: RE: image from 2011 Schramm paper
Thanks, Rita.
This is good to hear. Just so I?m clear: As long as the image was not published elsewhere, NIH may use the image in various products (exhibit, printed material, Web sites) and put it into our public domain image gallery. Is that correct?
Best,
Alisa
_________________________
Alisa Zapp Machalek
From: Rita Chang [mailto:rchang@annualreviews.org]
Sent: Thursday, October 04, 2012 3:56 PM
To: Machalek, Alisa Zapp (NIH/NIGMS) [E]
Subject: RE: image from 2011 Schramm paper
Dear Alisa,
Dr. Schramm is free to use whatever portion of his Annual Review article he would like for the exhibit. The only caveat is if the figure was originally adapted from another journal; in that case, he/you may need to verify that that is okay with the other publisher.
Hope that answers your question.
Best,
Rita
--
Rita Chang
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Fax: (650) 855-9815 | | | Keywords | | purine, transition state, inhibitor | | | Source | | Vern Schramm, Albert Einstein College of Medicine of Yeshiva University | | | Date | | | | | Credit Line | | Vern Schramm, Albert Einstein College of Medicine of Yeshiva University | | | Investigator | | | | | Record Type | | Illustration | | | Topic Area(s) | | ;#Chemistry, Biochemistry, and Pharmacology;#Molecular Structures;#Tools and Techniques;# | | | Previous Uses | | | | | Status | | Active | |
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