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View Entry | Antitoxin GhoS (Illustration 2)3428| Structure of the bacterial antitoxin protein GhoS. GhoS inhibits the production of a bacterial toxin, GhoT, which can contribute to antibiotic resistance. GhoS is the first known bacterial antitoxin that works by cleaving the messenger RNA that carries the instructions for making the toxin.
More information can be found in the paper: Wang X, Lord DM, Cheng HY, Osbourne DO, Hong SH, Sanchez-Torres V, Quiroga C, Zheng K, Herrmann T, Peti W, Benedik MJ, Page R, Wood TK. A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nat Chem Biol. 2012 Oct;8(10):855-61.
Related to 3427. | | Public Note | | | | | Internal Note | | Permission below:
Dear Tom and Alisa,
I have not published any images related to GhoS outside of those in the NCB manuscript, so if the images are sufficiently different than those in the manuscript, then I definitely approve them for dissemination at the NIH.
Please use the following credit: "Rebecca Page and Wolfgang Peti, Brown University and Thomas K. Wood, Pennsylvania State University".
Thanks,
Rebecca
On Tue, Sep 18, 2012 at 4:39 PM, Thomas Wood wrote:
Dear Alisa,
These images were not published so I do not believe they are restricted. I have copied the co-author, Rebecca Page, so that she may also indicate if she approves of their dissemination at NIH as her lab generated them for our publication.
For the credit, I suggest, ?Rebecca Page, Brown University and Thomas K. Wood, Pennsylvania State University?
Best regards,e
Tom
________________________________________________________________
Thomas K. Wood
Biotechnology Endowed Chair & Professor
Departments of Chemical Engineering & Biochemistry and Molecular Biology
Pennsylvania State University
161 Fenske Laboratory
University Park, PA 16802
814-863-4811 (voice)
814-865-7846 (FAX) | | | Keywords | | 3D | | | Source | | Rebecca Page and Wolfgang Peti, Brown University and Thomas K. Wood, Pennsylvania State University | | | Date | | 2012-10-02 00:00:00 | | | Credit Line | | Rebecca Page and Wolfgang Peti, Brown University and Thomas K. Wood, Pennsylvania State University | | | Investigator | | | | | Record Type | | Illustration | | | Topic Area(s) | | ;#Molecular Structures;# | | | Previous Uses | | | | | Status | | Active | |
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