• 21922400117668210961200703101548600238954PublicAssets/2716
    Mycobacterium tuberculosis
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    Mycobacterium tuberculosis

    2716

    Mycobacterium tuberculosis, the bacterium that causes tuberculosis, has infected one third of the world's population and is responsible for nearly two million deaths each year.
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    Internal NoteNote from Reuben Peters: Mycobacteria tuberculosis (Mtb) produces the diterpene edaxadiene (depicted in 3D), which acts to suppress maturation of Mtb containing phagosomes, such as that depicted (inset bottom). Intriguingly, M. bovis does not seem to have this capacity, which may provide a novel example of a species-specific virulence factor, as Mtb appears to be a more efficient human pathogen than M. bovis. I?ve also attached the original EM image (not colorized), which might help. Basically, the lysozymes are labelled with collodiol gold, while the Mtb are found as the electron dense bodies in other (non-maturing phagosomal) compartments. Hope this helps. http://publications.nigms.nih.gov/biobeat/09-11-18/index.html#5
    KeywordsTB, MTB, Bacteria,
    SourceReuben Peters, Iowa State University
    Date2009-11-23 00:00:00
    Credit LineDavid Russell, Cornell University
    InvestigatorReuben Peters, Iowa State University
    Record TypePhotograph
    Topic Area(s);#Injury and Illness;#
    Previous UsesNovember 2009 BB
    StatusActive

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