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    Mouse embryo showing Smad4 protein
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    Mouse embryo showing Smad4 protein

    2607

    This eerily glowing blob isn't an alien or a creature from the deep sea--it's a mouse embryo just eight and a half days old. The green shell and core show a protein called Smad4. In the center, Smad4 is telling certain cells to begin forming the mouse's liver and pancreas. Researchers identified a trio of signaling pathways that help switch on Smad4-making genes, starting immature cells on the path to becoming organs. The research could help biologists learn how to grow human liver and pancreas tissue for research, drug testing and regenerative medicine. In addition to NIGMS, NIH's National Institute of Diabetes and Digestive and Kidney Diseases also supported this work.
    Public Note
    Internal Notehttp://publications.nigms.nih.gov/biobeat/09-07-15/index.html#1
    Keywords
    SourceKenneth Zaret, Fox Chase Cancer Center
    Date2009-07-10 00:00:00
    Credit LineKenneth Zaret, Fox Chase Cancer Center
    InvestigatorKenneth Zaret, Fox Chase Cancer Center
    Record TypePhotograph
    Topic Area(s);#Cells;#Molecular Structures;#
    Previous UsesBiomedical Beat: July 15, 2009
    StatusActive

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