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Color coding of the Drosophila brain
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ID: 5843

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Color coding of the Drosophila brain
This video results from a research project to visualize which regions of the adult fruit fly (Drosophila) brain derive from each neural stem cell. ... more
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Color coding of the Drosophila brain
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ID: 5838

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Color coding of the Drosophila brain
This image results from a research project to visualize which regions of the adult fruit fly (Drosophila) brain derive from each neural stem cell. ... more
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Introduction to Genome Editing Using CRISPR/Cas9
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ID: 5815

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Introduction to Genome Editing Using CRISPR/Cas9
Genome editing using CRISPR/Cas9 is a rapidly expanding field of scientific research with emerging applications in disease treatment, medical therape... more
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Cas9 protein involved in the CRISPR gene-editing technology
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ID: 5816

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Cas9 protein involved in the CRISPR gene-editing technology
In the gene-editing tool CRISPR, a small strand of RNA identifies a specific chunk of DNA. Then the enzyme Cas9 (green) swoops in and cuts the double... more
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NCMIR Tongue 2
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ID: 5811

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NCMIR Tongue 2
Tongue
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Tongue 1
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ID: 5810

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Tongue 1
Microscopy image of tongue. One is a series of two.
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Transferrin receptor binding iron
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ID: 5809

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Transferrin receptor binding iron
Transferrin molecules (light gray), each bound by two iron atoms (red), are captured by TbpA proteins (light blue) on the surface of a pathogenic bac... more
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Mouse cerebellum in pink and blue
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ID: 5800

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Mouse cerebellum in pink and blue
The cerebellum is the brain's locomotion control center. Found at the base of your brain, the cerebellum is a single layer of tissue with deep folds ... more
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Mouse cerebellum
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ID: 5795

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Mouse cerebellum
The cerebellum is the brain's locomotion control center. Found at the base of your brain, the cerebellum is a single layer of tissue with deep folds ... more
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Mouse retina
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ID: 5793

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Mouse retina
What looks like the gossamer wings of a butterfly is actually the retina of a mouse, delicately snipped to lay flat and sparkling with fluorescent mo... more
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Ribosome illustration from PDB
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ID: 5780

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Ribosome illustration from PDB
Ribosomes are complex machines made up of more than 50 proteins and three or four strands of genetic material called ribosomal RNA (rRNA). The busy c... more
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Microsporidia in roundworm 3
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ID: 5779

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Microsporidia in roundworm 3
Many disease-causing microbes rejigger their host’s metabolism and cells for their own ends. A group of pathogenic fungi called microsporidia—which i... more
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Microsporidia in roundworm 2
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ID: 5778

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Microsporidia in roundworm 2
Many disease-causing microbes rejigger their host’s metabolism and cells for their own ends. A group of pathogenic fungi called microsporidia—which i... more
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Microsporidia in roundworm 1
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ID: 5777

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Microsporidia in roundworm 1
Many disease-causing microbes rejigger their host’s metabolism and cells for their own ends. A group of pathogenic fungi called microsporidia—which i... more
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Confocal microscopy image of two Drosophila ovarioles
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ID: 5772

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Confocal microscopy image of two Drosophila ovarioles
Ovarioles in female insects are tubes in which egg cells (called oocytes) form at one end and complete their development as they reach the other end ... more
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Lysosome clusters around amyloid plaques
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ID: 5771

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Lysosome clusters around amyloid plaques
It's probably most people's least favorite activity, but we still need to do it--take out our trash. Otherwise our homes will get cluttered and smell... more
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EM of yeast cell division
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ID: 5770

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EM of yeast cell division
Cell division is an incredibly coordinated process. It not only ensures that the new cells formed during this event have a full set of chromosomes, b... more
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Multivesicular bodies containing intralumenal vesicles assemble at the vacuole 1
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ID: 5769

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Multivesicular bodies containing intralumenal vesicles assemble at the vacuole 1
Collecting and transporting cellular waste and sorting it into recylable and nonrecylable pieces is a complex business in the cell. One key player in... more
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Multivesicular bodies containing intralumenal vesicles assemble at the vacuole 2
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ID: 5768

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Multivesicular bodies containing intralumenal vesicles assemble at the vacuole 2
Collecting and transporting cellular waste and sorting it into recylable and nonrecylable pieces is a complex business in the cell. One key player in... more
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Multivesicular bodies containing intralumenal vesicles assemble at the vacuole 3
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ID: 5767

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Multivesicular bodies containing intralumenal vesicles assemble at the vacuole 3
Collecting and transporting cellular waste and sorting it into recylable and nonrecylable pieces is a complex business in the cell. One key player in... more
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A chromosome goes missing in anaphase
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ID: 5766

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A chromosome goes missing in anaphase
Anaphase is the critical step during mitosis when sister chromosomes are disjoined and directed to opposite spindle poles, ensuring equal distributio... more
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Mitotic cell awaits chromosome alignment
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ID: 5765

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Mitotic cell awaits chromosome alignment
During mitosis, spindle microtubules (red) attach to chromosome pairs (blue), directing them to the spindle equator. This midline alignment is critic... more
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Host infection stimulates antibiotic resistance
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ID: 5764

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Host infection stimulates antibiotic resistance
This illustration shows pathogenic bacteria behave like a Trojan horse: switching from antibiotic susceptibility to resistance during infection. Salm... more
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Cells lining the airways of the lung
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ID: 5763

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Cells lining the airways of the lung
Cells lining the airways (called the trachea) in our lungs are known as the mucociliary escalator and are our first line of defense against inhaled b... more
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Panorama view of golden mitochondria
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ID: 5762

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Panorama view of golden mitochondria
Mitochondria are the powerhouses of the cells, generating the energy the cells need to do their tasks and to stay alive. Researchers have studied mit... more
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A panorama view of cells
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ID: 5761

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A panorama view of cells
This photograph shows a panoramic view of HeLa cells, a cell line many researchers use to study a large variety of important research questions. The ... more
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Annotated TEM cross-section of C. elegans (roundworm)
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ID: 5760

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Annotated TEM cross-section of C. elegans (roundworm)
The worm Caenorhabditis elegans is a popular laboratory animal because its small size and fairly simple body make it easy to study. Scientist use thi... more
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TEM cross-section of C. elegans (roundworm)
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ID: 5759

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TEM cross-section of C. elegans (roundworm)
The worm Caenorhabditis elegans is a popular laboratory animal because its small size and fairly simple body make it easy to study. Scientist use thi... more
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Migrating pigment cells
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ID: 5758

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Migrating pigment cells
Pigment cells are cells that give skin its color. In fishes and amphibians, like frogs and salamanders, pigment cells are responsible for the charact... more
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Pigment cells in the fin of pearl danio
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ID: 5757

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Pigment cells in the fin of pearl danio
Pigment cells are cells that give skin its color. In fishes and amphibians, like frogs and salamanders, pigment cells are responsible for the charact... more
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Pigment cells in fish skin
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ID: 5756

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Pigment cells in fish skin
Pigment cells are cells that give skin its color. In fishes and amphibians, like frogs and salamanders, pigment cells are responsible for the charact... more
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Autofluorescent xanthophores in zebrafish skin
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ID: 5755

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Autofluorescent xanthophores in zebrafish skin
Pigment cells are cells that give skin its color. In fishes and amphibians, like frogs and salamanders, pigment cells are responsible for the charact... more
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Zebrafish pigment cell
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ID: 5754

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Zebrafish pigment cell
Pigment cells are cells that give skin its color. In fishes and amphibians, like frogs and salamanders, pigment cells are responsible for the charact... more
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Clathrin-mediated endocytosis
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ID: 5753

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Clathrin-mediated endocytosis
Endocytosis is the process by which cells are able to take up membrane and extracellular materials through the formation of a small intracellular bub... more
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Video (63 MB)
Genetically identical mycobacteria respond differently to antibiotic 2
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ID: 5752

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Genetically identical mycobacteria respond differently to antibiotic 2
Antibiotic resistance in microbes is a serious health concern. So researchers have turned their attention to how bacteria undo the action of some ant... more
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Genetically identical mycobacteria respond differently to antibiotic 1
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ID: 5751

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Genetically identical mycobacteria respond differently to antibiotic 1
Antibiotic resistance in microbes is a serious health concern. So researchers have turned their attention to how bacteria undo the action of some ant... more
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Dynamic cryo-EM model of the human transcription preinitiation complex
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ID: 5730

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Dynamic cryo-EM model of the human transcription preinitiation complex
Gene transcription is a process by which information encoded in DNA is transcribed into RNA. It's essential for all life and requires the activity of... more
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Assembly of the HIV capsid
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ID: 5729

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Assembly of the HIV capsid
The HIV capsid is pear-shaped structure that is made of proteins the virus needs to mature and become infective. The capsid is inside the virus and d... more
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Nucleolus subcompartments spontaneously self-assemble 4
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ID: 3793

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Nucleolus subcompartments spontaneously self-assemble 4
What looks a little like distant planets with some mysterious surface features are actually assemblies of proteins normally found in the cell's nucle... more
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Nucleolus subcompartments spontaneously self-assemble 3
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ID: 3792

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Nucleolus subcompartments spontaneously self-assemble 3
What looks a little like distant planets with some mysterious surface features are actually assemblies of proteins normally found in the cell's nucle... more
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Nucleolus subcompartments spontaneously self-assemble 2
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ID: 3791

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Nucleolus subcompartments spontaneously self-assemble 2
The nucleolus is a small but very important protein complex located in the cell's nucleus. It forms on the chromosomes at the location where the gene... more
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Nucleolus subcompartments spontaneously self-assemble 1
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ID: 3789

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Nucleolus subcompartments spontaneously self-assemble 1
The nucleolus is a small but very important protein complex located in the cell's nucleus. It forms on the chromosomes at the location where the gene... more
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Yeast cells pack a punch
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ID: 3788

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Yeast cells pack a punch
Although they are tiny, microbes that are growing in confined spaces can generate a lot of pressure. In this video, yeast cells grow in a small chamb... more
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In vitro assembly of a cell-signaling pathway
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ID: 3787

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In vitro assembly of a cell-signaling pathway
T cells are white blood cells that are important in defending the body against bacteria, viruses and other pathogens. Each T cell carries proteins, c... more
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Movie of in vitro assembly of a cell-signaling pathway
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ID: 3786

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Movie of in vitro assembly of a cell-signaling pathway
T cells are white blood cells that are important in defending the body against bacteria, viruses and other pathogens. Each T cell carries proteins, c... more
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A multicolored fish scale 2
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ID: 3783

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A multicolored fish scale 2
Each of the tiny colored specs in this image is a cell on the surface of a fish scale. To better understand how wounds heal, scientists have inserted... more
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A multicolored fish scale 1
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ID: 3782

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A multicolored fish scale 1
Each of the colored specs in this image is a cell on the surface of a fish scale. To better understand how wounds heal, scientists have inserted gene... more
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Modeling How Molecules Move Inside Cells
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ID: 3781

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Modeling How Molecules Move Inside Cells
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Precisely Delivering Chemical Cargo to Cells
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ID: 3779

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Precisely Delivering Chemical Cargo to Cells
Moving protein or other molecules to specific cells to treat or examine them has been a major biological challenge. Scientists have now developed a t... more
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The Proteasome: The Cell's Trash Processor in Action
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ID: 3772

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The Proteasome: The Cell's Trash Processor in Action
Our cells are constantly removing and recycling molecular waste. This video shows one way cells process their trash.
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Molecular model of freshly made Rous sarcoma virus
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ID: 3771

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Molecular model of freshly made Rous sarcoma virus
Viruses have been the foes of animals and other organisms for time immemorial. For almost as long, they've stayed well hidden from view because they ... more
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TFIID complex binds DNA to start gene transcription
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ID: 3766

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TFIID complex binds DNA to start gene transcription
Gene transcription is a process by which the genetic information encoded in DNA is transcribed into RNA. It's essential for all life and requires the... more
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Trypanosoma brucei, the cause of sleeping sickness
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ID: 3765

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Trypanosoma brucei, the cause of sleeping sickness
Trypanosoma brucei is a single-cell parasite that causes sleeping sickness in humans. Scientists have been studying trypanosomes for some time becaus... more
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Movie of the 19S proteasome subunit processing a protein substrate
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ID: 3764

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Movie of the 19S proteasome subunit processing a protein substrate
The proteasome is a critical multiprotein complex in the cell that breaks down and recycles proteins that have become damaged or are no longer needed... more
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The 26S proteasome engages with a protein substrate
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ID: 3763

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The 26S proteasome engages with a protein substrate
The proteasome is a critical multiprotein complex in the cell that breaks down and recycles proteins that have become damaged or are no longer needed... more
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Dengue virus membrane protein structure
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ID: 3758

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Dengue virus membrane protein structure
Dengue virus is a mosquito-borne illness that infects millions of people in the tropics and subtropics each year. Like many viruses, dengue is enclos... more
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Protective membrane and membrane proteins of the dengue virus visualized with cryo-EM
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ID: 3756

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Protective membrane and membrane proteins of the dengue virus visualized with cryo-EM
Dengue virus is a mosquito-borne illness that infects millions of people in the tropics and subtropics each year. Like many viruses, dengue is enclos... more
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Cryo-EM reveals how the HIV capsid attaches to a human protein to evade immune detection
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ID: 3755

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Cryo-EM reveals how the HIV capsid attaches to a human protein to evade immune detection
The illustration shows the capsid of human immunodeficiency virus (HIV) whose molecular features were resolved with cryo-electron microscopy (cryo-EM... more
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Circadian rhythm neurons in the fruit fly brain
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ID: 3754

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Circadian rhythm neurons in the fruit fly brain
Some nerve cells (neurons) in the brain keep track of the daily cycle. This time-keeping mechanism, called the circadian clock, is found in all anima... more
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Coronavirus spike protein structure
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ID: 3753

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Coronavirus spike protein structure
Coronaviruses are enveloped viruses responsible for 30 percent of mild respiratory infections and atypical deadly pneumonia in humans worldwide. Thes... more
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A dynamic model of the DNA helicase protein complex
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ID: 3750

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A dynamic model of the DNA helicase protein complex
This short video shows a model of the DNA helicase in yeast. DNA helicase comprises 11 proteins that work together to unwind DNA during the process o... more
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3D image of actin in a cell
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ID: 3749

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3D image of actin in a cell
Actin is an essential protein in a cell's skeleton (cytoskeleton). It forms a dense network of thin filaments in the cell. Here, researchers have use... more
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Cryo-electron microscopy of the dengue virus showing protective membrane and membrane proteins
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ID: 3748

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Cryo-electron microscopy of the dengue virus showing protective membrane and membrane proteins
Dengue virus is a mosquito-borne illness that infects millions of people in the tropics and subtropics each year. Like many viruses, dengue is enclos... more
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Cryo-electron microscopy revealing the "wasabi receptor
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ID: 3747

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Cryo-electron microscopy revealing the "wasabi receptor
The TRPA1 protein is responsible for the burn you feel when you taste a bite of sushi topped with wasabi. Known therefore informally as the "wasabi r... more
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Serum albumin structure 3
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ID: 3746

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Serum albumin structure 3
Serum albumin (SA) is the most abundant protein in the blood plasma of mammals. SA has a characteristic heart-shape structure and is a highly versati... more
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Serum albumin structure 2
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ID: 3745

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Serum albumin structure 2
Serum albumin (SA) is the most abundant protein in the blood plasma of mammals. SA has a characteristic heart-shape structure and is a highly versati... more
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Serum albumin structure 1
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ID: 3744

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Serum albumin structure 1
Serum albumin (SA) is the most abundant protein in the blood plasma of mammals. SA has a characteristic heart-shape structure and is a highly versati... more
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Developing Arabidopsis flower buds
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ID: 3743

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Developing Arabidopsis flower buds
Flower development is a carefully orchestrated, genetically programmed process that ensures that the male (stamen) and female (pistil) organs form in... more
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Confocal microscopy of perineuronal nets in the brain 2
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ID: 3742

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Confocal microscopy of perineuronal nets in the brain 2
The photo shows a confocal microscopy image of perineuronal nets (PNNs), which are specialized extracellular matrix (ECM) structures in the brain. Th... more
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Confocal microscopy of perineuronal nets in the brain 1
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ID: 3741

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Confocal microscopy of perineuronal nets in the brain 1
The photo shows a confocal microscopy image of perineuronal nets (PNNs), which are specialized extracellular matrix (ECM) structures in the brain. Th... more
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Transmission electron microscopy showing cross-section of the node of Ranvier
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ID: 3740

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Transmission electron microscopy showing cross-section of the node of Ranvier
Nodes of Ranvier are short gaps in the myelin sheath surrounding myelinated nerve cells (axons). Myelin insulates axons, and the node of Ranvier is w... more
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Scanning electron microscopy of the ECM on the surface of a calf muscle
Photograph
ID: 3739

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Scanning electron microscopy of the ECM on the surface of a calf muscle
This image shows the extracellular matrix (ECM) on the surface of a soleus (lower calf) muscle in light brown and blood vessels in pink. Near the bot... more
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Transmission electron microscopy of coronary artery wall with elastin-rich ECM pseudocolored in light brown
Photograph
ID: 3738

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Transmission electron microscopy of coronary artery wall with elastin-rich ECM pseudocolored in light brown
Elastin is a fibrous protein in the extracellular matrix (ECM). It is abundant in artery walls like the one shown here. As its name indicates, elasti... more
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A bundle of myelinated peripheral nerve cells (axons)
Photograph
ID: 3737

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A bundle of myelinated peripheral nerve cells (axons)
The extracellular matrix (ECM) is most prevalent in connective tissues but also is present between the stems (axons) of nerve cells. The axons of ner... more
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Transmission electron microscopy of myelinated axons with ECM between the axons
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ID: 3736

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Transmission electron microscopy of myelinated axons with ECM between the axons
The extracellular matrix (ECM) is most prevalent in connective tissues but also is present between the stems (axons) of nerve cells, as shown here. B... more
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Scanning electron microscopy of collagen fibers
Photograph
ID: 3735

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Scanning electron microscopy of collagen fibers
This image shows collagen, a fibrous protein that's the main component of the extracellular matrix (ECM). Collagen is a strong, ropelike molecule tha... more
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Molecular interactions at the astrocyte nuclear membrane
Illustration
ID: 3734

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Molecular interactions at the astrocyte nuclear membrane
These ripples of color represent the outer membrane of the nucleus inside an astrocyte, a star-shaped cell inside the brain. Some proteins (green) ac... more
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A molecular interaction network in yeast 3
Illustration
ID: 3733

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A molecular interaction network in yeast 3
The image visualizes a part of the yeast molecular interaction network. The lines in the network represent connections among genes (shown as little d... more
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A molecular interaction network in yeast 2
Illustration
ID: 3732

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A molecular interaction network in yeast 2
The image visualizes a part of the yeast molecular interaction network. The lines in the network represent connections among genes (shown as little d... more
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A molecular interaction network in yeast 1
Illustration
ID: 3730

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A molecular interaction network in yeast 1
The image visualizes a part of the yeast molecular interaction network. The lines in the network represent connections among genes (shown as little d... more
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A molecular switch strips transcription factor from DNA
Video
ID: 3729

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A molecular switch strips transcription factor from DNA
In this video, Rice University scientists used molecular modeling with a mathematical algorithm called AWSEM (for associative memory, water-mediated,... more
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Quorum-sensing inhibitor limits bacterial growth
Video
ID: 3728

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Quorum-sensing inhibitor limits bacterial growth
To simulate the consequences of disrupting bacterial cell-to-cell communication, called quorum sensing, in the crypts (small chambers within the colo... more
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Zinc levels in a plant leaf
Photograph
ID: 3727

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Zinc levels in a plant leaf
Zinc is required for the function of more than 300 enzymes, including those that help regulate gene expression, in various organisms including humans... more
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Fluorescent microscopy of kidney tissue--close-up
Photograph
ID: 3725

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Fluorescent microscopy of kidney tissue--close-up
This photograph of kidney tissue, taken using fluorescent light microscopy, shows a close-up view of part of image 3273. Kidneys filter the blood, re... more
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Snowflake DNA origami
Photograph
ID: 3724

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Snowflake DNA origami
An atomic force microscopy image shows DNA folded into an intricate, computer-designed structure. The image is featured on Biomedical Beat blog post ... more
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Fluorescent microscopy of kidney tissue
Photograph
ID: 3723

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Fluorescent microscopy of kidney tissue
This photograph of kidney tissue was taken using fluorescent light microscopy. For a close-up version and more detailed description, see image 3725. ... more
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Cas4 nuclease protein structure
Illustration
ID: 3720

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Cas4 nuclease protein structure
This wreath represents the molecular structure of a protein, Cas4, which is part of a system, known as CRISPR, that bacteria use to protect themselve... more
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CRISPR illustration
Illustration
ID: 3719

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CRISPR illustration
This illustration shows, in simplified terms, how the CRISPR-Cas9 system can be used as a gene-editing tool. The illustration includes a cartoon with... more
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A Bacillus subtilis biofilm grown in a Petri dish
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ID: 3718

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A Bacillus subtilis biofilm grown in a Petri dish
Bacterial biofilms are tightly knit communities of bacterial cells growing on, for example, solid surfaces, such as in water pipes or on teeth. Here,... more
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Fission yeast cell undergoing abnormal mitosis
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ID: 3693

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Fission yeast cell undergoing abnormal mitosis
Defects in early DNA replication result in abnormal mitosis. The image shows a disruption of normal cell division in a fission yeast cell having a mu... more
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Microscopy image of bird-and-flower DNA origami
Photograph
ID: 3690

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Microscopy image of bird-and-flower DNA origami
An atomic force microscopy image shows DNA folded into an intricate, computer-designed structure. Image is featured on Biomedical Beat blog post Cool... more
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Computer sketch of bird-and-flower DNA origami
Illustration
ID: 3689

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Computer sketch of bird-and-flower DNA origami
A computer-generated sketch of a DNA origami folded into a flower-and-bird structure. Image is featured on Biomedical Beat blog post Cool Image: DNA ... more
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Brain cells in the hippocampus
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ID: 3688

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Brain cells in the hippocampus
Hippocampal cells in culture with neuron in green, showing hundreds of the small protrusions known as dendritic spines. The dendrites of other neuron... more
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Hippocampal neuron in culture
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ID: 3687

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Hippocampal neuron in culture
Hippocampal neuron in culture. Dendrites are green, dendritic spines are red and DNA in cell's nucleus is blue. Image is featured on Biomedical Beat ... more
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Hippocampal neuron from rodent brain
Photograph
ID: 3686

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Hippocampal neuron from rodent brain
Hippocampal neuron from rodent brain with dendrites shown in blue. The hundreds of tiny magenta, green and white dots are the dendritic spines of exc... more
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STORM image of axonal cytoskeleton
Photograph
ID: 3678

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STORM image of axonal cytoskeleton
This image shows the long, branched structures (axons) of nerve cells. Running horizontally across the middle of the photo is an axon wrapped in ring... more
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Human skeletal muscle
Photograph
ID: 3677

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Human skeletal muscle
Cross section of human skeletal muscle. Image taken with a confocal fluorescent light microscope.
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NCMIR kidney-1
Photograph
ID: 3675

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NCMIR kidney-1
Stained kidney tissue. The kidney is an essential organ responsible for disposing wastes from the body and for maintaining healthy ion levels in the ... more
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DNA and actin in cultured fibroblast cells
Photograph
ID: 3670

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DNA and actin in cultured fibroblast cells
DNA (blue) and actin (red) in cultured fibroblast cells.
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Mitochondria from rat heart muscle cell_2
Photograph
ID: 3664

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Mitochondria from rat heart muscle cell_2
These mitochondria (brown) are from the heart muscle cell of a rat. Mitochondria have an inner membrane that folds in many places (and that appears h... more
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Mitochondrion from insect flight muscle
Illustration
ID: 3662

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Mitochondrion from insect flight muscle
This is a tomographic reconstruction of a mitochondrion from an insect flight muscle. Mitochondria are cellular compartments that are best known as t... more
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Mitochondria from rat heart muscle cell
Photograph
ID: 3661

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Mitochondria from rat heart muscle cell
These mitochondria (red) are from the heart muscle cell of a rat. Mitochondria have an inner membrane that folds in many places (and that appears her... more
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Ribonuclease P structure
Illustration
ID: 3660

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Ribonuclease P structure
Ribbon diagram showing the structure of Ribonuclease P with tRNA.
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Electrostatic map of human spermine synthase
Illustration
ID: 3658

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Electrostatic map of human spermine synthase
From PDB entry 3c6k, Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine.
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Fruit fly ovary_2
Photograph
ID: 3656

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Fruit fly ovary_2
A fruit fly ovary, shown here, contains as many as 20 eggs. Fruit flies are not merely tiny insects that buzz around overripe fruit--they are a vener... more
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How a microtubule builds and deconstructs
Video
ID: 3650

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How a microtubule builds and deconstructs
A microtubule, part of the cell's skeleton, builds and deconstructs.
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Video (2 MB)
Symmetrically and asymmetrically elongating cells
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ID: 3648

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Symmetrically and asymmetrically elongating cells
Merged fluorescent images of symmetrically (left) or asymmetrically (right) elongating HeLa cells at the end of early anaphase (magenta) and late ana... more
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Endothelial cells
Photograph
ID: 3647

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Endothelial cells
This image mostly shows normal cultured endothelial cells expressing green fluorescent protein targeted to the Golgi apparatus (yellow-green) and sta... more
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Cells lining the trachea
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ID: 3646

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Cells lining the trachea
In this image, viewed with a ZEISS ORION NanoFab microscope, the community of cells lining a mouse airway is magnified more than 10,000 times. This c... more
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Zebrafish embryo
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ID: 3644

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Zebrafish embryo
Just 22 hours after fertilization, this zebrafish embryo is already taking shape. By 36 hours, all of the major organs will have started to form. The... more
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A mammalian eye has approximately 70 different cell types
Photograph
ID: 3641

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A mammalian eye has approximately 70 different cell types
The incredible complexity of a mammalian eye (in this case from a mouse) is captured here. Each color represents a different type of cell. In total, ... more
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Cerebellum: the brain's locomotion control center
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ID: 3639

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Cerebellum: the brain's locomotion control center
The cerebellum of a mouse is shown here in cross-section. The cerebellum is the brain's locomotion control center. Every time you shoot a basketball,... more
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HIV, the AIDS virus, infecting a human cell
Photograph
ID: 3638

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HIV, the AIDS virus, infecting a human cell
This human T cell (blue) is under attack by HIV (yellow), the virus that causes AIDS. The virus specifically targets T cells, which play a critical r... more
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Purkinje cells are one of the main cell types in the brain
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ID: 3637

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Purkinje cells are one of the main cell types in the brain
This image captures Purkinje cells (red), one of the main types of nerve cell found in the brain. These cells have elaborate branching structures cal... more
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Jellyfish, viewed with ZEISS Lightsheet Z.1 microscope
Photograph
ID: 3636

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Jellyfish, viewed with ZEISS Lightsheet Z.1 microscope
Jellyfish are especially good models for studying the evolution of embryonic tissue layers. Despite being primitive, jellyfish have a nervous system ... more
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The eye uses many layers of nerve cells to convert light into sight
Photograph
ID: 3635

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The eye uses many layers of nerve cells to convert light into sight
This image captures the many layers of nerve cells in the retina. The top layer (green) is made up of cells called photoreceptors that convert light ... more
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Cells use bubble-like structures called vesicles to transport cargo
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ID: 3634

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Cells use bubble-like structures called vesicles to transport cargo
Cells use bubble-like structures called vesicles (yellow) to import, transport and export cargo and in cellular communication. A single cell may be f... more
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Cells lining the blood vessel walls
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ID: 3633

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Cells lining the blood vessel walls
The structure of the endothelium, the thin layer of cells that line our arteries and veins, is visible here. The endothelium is like a gatekeeper, co... more
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Developing nerve cells
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ID: 3632

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Developing nerve cells
These developing mouse nerve cells have a nucleus (yellow) surrounded by a cell body, with long extensions called axons and thin branching structures... more
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Dividing cells showing chromosomes and cell skeleton
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ID: 3631

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Dividing cells showing chromosomes and cell skeleton
This pig cell is in the process of dividing. The chromosomes (purple) have already replicated and the duplicates are being pulled apart by fibers of ... more
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Three muscle fibers; the middle has a defect found in some neuromuscular diseases
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ID: 3630

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Three muscle fibers; the middle has a defect found in some neuromuscular diseases
Of the three muscle fibers shown here, the one on the right and the one on the left are normal. The middle fiber is deficient a large protein called ... more
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Skin cancer cells--squamous cell carcinoma
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ID: 3628

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Skin cancer cells--squamous cell carcinoma
This image shows the uncontrolled growth of cells in squamous cell carcinoma, the second most common form of skin cancer. If caught early, squamous c... more
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Larvae from the parasitic worm that causes schistosomiasis
Photograph
ID: 3627

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Larvae from the parasitic worm that causes schistosomiasis
The parasitic worm that causes schistosomiasis hatches in water and grows up in a freshwater snail, as shown here. Once mature, the worm swims back i... more
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Bone cancer cell
Photograph
ID: 3626

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Bone cancer cell
This image shows an osteosarcoma cell with DNA in blue, energy factories (mitochondria) in yellow and actin filaments, part of the cellular skeleton,... more
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Mouth parts of a lone star tick
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ID: 3625

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Mouth parts of a lone star tick
The mouth parts of a lone star tick are revealed in vivid detail. The center of the mouth (yellow) is covered with many tiny barbs. These barbs keep ... more
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Fibroblasts with nuclei in blue, energy factories in green and the actin cytoskeleton in red
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ID: 3624

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Fibroblasts with nuclei in blue, energy factories in green and the actin cytoskeleton in red
The cells shown here are fibroblasts, one of the most common cells in mammalian connective tissue. These particular cells were taken from a mouse emb... more
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Skin cancer cells from a mouse show how cells attach at contact points
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ID: 3622

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Skin cancer cells from a mouse show how cells attach at contact points
These skin cancer cells come from a mouse, an animal commonly used to study human diseases (including many types of cancer) and to test the effective... more
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Q fever bacteria in an infected cell
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ID: 3621

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Q fever bacteria in an infected cell
This image shows Q-fever bacteria (yellow), which infect cows, sheep and goats around the world and can infect humans, as well. When caught early, Q ... more
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Anglerfish ovary cross-section
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ID: 3620

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Anglerfish ovary cross-section
This image captures the spiral-shaped ovary of an anglerfish in cross-section. Once matured, these eggs will be released in a gelatinous, floating ma... more
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String-like Ebola virus peeling off an infected cell
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ID: 3619

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String-like Ebola virus peeling off an infected cell
After multiplying inside a host cell, the stringlike Ebola virus is emerging to infect more cells. Ebola is a rare, often fatal disease that occurs p... more
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Hair cells: the sound-sensing cells in the ear
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ID: 3618

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Hair cells: the sound-sensing cells in the ear
These cells get their name from the hairlike structures that extend from them into the fluid-filled tube of the inner ear. When sound reaches the ear... more
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Cells keep their shape with actin filaments and microtubules
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ID: 3617

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Cells keep their shape with actin filaments and microtubules
This image shows a normal fibroblast, a type of cell that is common in connective tissue and frequently studied in research labs. This cell has a hea... more
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Weblike sheath covering developing egg chambers in a giant grasshopper
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ID: 3616

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Weblike sheath covering developing egg chambers in a giant grasshopper
The lubber grasshopper, found throughout the southern United States, is frequently used in biology classes to teach students about the respiratory sy... more
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An insect tracheal cell delivers air to muscles
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ID: 3615

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An insect tracheal cell delivers air to muscles
Insects like the fruit fly use an elaborate network of branching tubes called trachea (green) to transport oxygen throughout their bodies. Fruit flie... more
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Birth of a yeast cell
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ID: 3614

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Birth of a yeast cell
Yeast make bread, beer and wine. And like us, yeast can reproduce sexually. A mother and father cell fuse and create one large cell that contains fou... more
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Abnormal, spiky fibroblast
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ID: 3613

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Abnormal, spiky fibroblast
Cells missing a key molecule look spiky and cannot move normally. This is a fibroblast, a connective tissue cell that plays an important role in woun... more
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Anthrax bacteria (green) being swallowed by an immune system cell
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ID: 3612

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Anthrax bacteria (green) being swallowed by an immune system cell
Multiple anthrax bacteria (green) being enveloped by an immune system cell (purple). Anthrax bacteria live in soil and form dormant spores that can s... more
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Tiny strands of tubulin, a protein in a cell's skeleton
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ID: 3611

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Tiny strands of tubulin, a protein in a cell's skeleton
Just as our bodies rely on bones for structural support, our cells rely on a cellular skeleton. In addition to helping cells keep their shape, this c... more
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Human liver cell (hepatocyte)
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ID: 3610

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Human liver cell (hepatocyte)
Hepatocytes, like the one shown here, are the most abundant type of cell in the human liver. They play an important role in building proteins; produc... more
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Pollen grains: male germ cells in plants and a cause of seasonal allergies
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ID: 3609

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Pollen grains: male germ cells in plants and a cause of seasonal allergies
Those of us who get sneezy and itchy-eyed every spring or fall may have pollen grains, like those shown here, to blame. Pollen grains are the male ge... more
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Fruit fly ovary
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ID: 3607

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Fruit fly ovary
A fruit fly ovary, shown here, contains as many as 20 eggs. Fruit flies are not merely tiny insects that buzz around overripe fruit--they are a vener... more
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Flower-forming cells in a small plant related to cabbage (Arabidopsis)
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ID: 3606

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Flower-forming cells in a small plant related to cabbage (Arabidopsis)
In plants, as in animals, stem cells can transform into a variety of different cell types. The stem cells at the growing tip of this Arabidopsis plan... more
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Brain showing hallmarks of Alzheimer's disease
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ID: 3604

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Brain showing hallmarks of Alzheimer's disease
Along with blood vessels (red) and nerve cells (green), this mouse brain shows abnormal protein clumps known as plaques (blue). These plaques multipl... more
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Salivary gland in the developing fruit fly
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ID: 3603

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Salivary gland in the developing fruit fly
For fruit flies, the salivary gland is used to secrete materials for making the pupal case, the protective enclosure in which a larva transforms into... more
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Fat cells (red) and blood vessels (green)
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ID: 3600

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Fat cells (red) and blood vessels (green)
A mouse's fat cells (red) are shown surrounded by a network of blood vessels (green). Fat cells store and release energy, protect organs and nerve ti... more
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Skin cell (keratinocyte)
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ID: 3599

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Skin cell (keratinocyte)
This normal human skin cell was treated with a growth factor that triggered the formation of specialized protein structures that enable the cell to m... more
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Developing zebrafish fin
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ID: 3598

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Developing zebrafish fin
Originally from the waters of India, Nepal and neighboring countries, zebrafish can now be found swimming in science labs (and home aquariums) throug... more
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DNA replication origin recognition complex (ORC)
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ID: 3597

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DNA replication origin recognition complex (ORC)
A study published in March 2012 used cryo-electron microscopy to determine the structure of the DNA replication origin recognition complex (ORC), a s... more
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Heart rates time series (still)
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ID: 3596

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Heart rates time series (still)
See video with ID 2580 in Image Gallery.
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Fly cells
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ID: 3594

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Fly cells
If a picture is worth a thousand words, what's a movie worth? For researchers studying cell migration, a "documentary" of fruit fly cells (bright gre... more
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Isolated Planarian Pharynx
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ID: 3593

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Isolated Planarian Pharynx
The feeding tube, or pharynx, of a planarian worm with cilia shown in red and muscle fibers shown in green
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Math from the heart
Video
ID: 3592

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Math from the heart
Watch a cell ripple toward a beam of light that turns on a movement-related protein.
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Fruit fly spermatids
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ID: 3590

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Fruit fly spermatids
Developing spermatids (precursors of mature sperm cells) begin as small, round cells and mature into long-tailed, tadpole-shaped ones. In the sperm c... more
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Human blood cells with Borrelia hermsii, a bacterium that causes relapsing fever
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ID: 3586

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Human blood cells with Borrelia hermsii, a bacterium that causes relapsing fever
Relapsing fever is caused by a bacterium and transmitted by certain soft-bodied ticks or body lice. The disease is seldom fatal in humans, but it can... more
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Relapsing fever bacterium (gray) and red blood cells
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ID: 3585

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Relapsing fever bacterium (gray) and red blood cells
Relapsing fever is caused by a bacterium and transmitted by certain soft-bodied ticks or body lice. The disease is seldom fatal in humans, but it can... more
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Rotavirus structure
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ID: 3584

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Rotavirus structure
This image shows a computer-generated, three-dimensional map of the rotavirus structure. This virus infects humans and other animals and causes sever... more
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Bee venom toxin destroying a cell
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ID: 3583

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Bee venom toxin destroying a cell
This video condenses 6.5 minutes into less than a minute to show how the toxin in bee venom, called melittin, destroys an animal or bacterial cell. W... more
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V. Cholerae Biofilm
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ID: 3580

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V. Cholerae Biofilm
Industrious V. cholerae bacteria (yellow) tend to thrive in denser biofilms (left) while moochers (red) thrive in weaker biofilms (right). More infor... more
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Bubonic plague bacteria on part of the digestive system in a rat flea
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ID: 3576

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Bubonic plague bacteria on part of the digestive system in a rat flea
Here, bubonic plague bacteria (yellow) are shown in the digestive system of a rat flea (purple). Carried by rodents and spread by fleas, the bubonic ... more
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Cytonemes in developing fruit fly cells
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ID: 3574

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Cytonemes in developing fruit fly cells
Scientists have long known that multicellular organisms use biological molecules produced by one cell and sensed by another to transmit messages that... more
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Myotonic dystrophy type 2 genetic defect
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ID: 3573

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Myotonic dystrophy type 2 genetic defect
Scientists revealed a detailed image of the genetic defect that causes myotonic dystrophy type 2 and used that information to design drug candidates ... more
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HIV-1 virus in the colon
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ID: 3571

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HIV-1 virus in the colon
A tomographic reconstruction of the colon shows the location of large pools of HIV-1 virus particles (in blue) located in the spaces between adjacent... more
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RSV-Infected Cell
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ID: 3567

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RSV-Infected Cell
Viral RNA (red) in an RSV-infected cell. More information about the research behind this image can be found in a Biomedical Beat Blog posting from Ja... more
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Mouse colon with gut bacteria
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ID: 3566

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Mouse colon with gut bacteria
A section of mouse colon with gut bacteria (center, in green) residing within a protective pocket. Understanding how microorganisms colonize the gut ... more
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Podocytes from a chronically diseased kidney
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ID: 3565

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Podocytes from a chronically diseased kidney
This scanning electron microscope (SEM) image shows podocytes--cells in the kidney that play a vital role in filtering waste from the bloodstream--fr... more
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A Drug's Life in the Body
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ID: 3563

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A Drug's Life in the Body
Medicines taken by mouth oral) pass through the liver before they are absorbed into the bloodstream. Other forms of drug administration bypass the li... more
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Bioluminescent imaging in adult zebrafish 04
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ID: 3559

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Bioluminescent imaging in adult zebrafish 04
Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. This image shows... more
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Bioluminescent imaging in adult zebrafish 03
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ID: 3558

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Bioluminescent imaging in adult zebrafish 03
Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. In this image, a... more
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Bioluminescent imaging in adult zebrafish 02
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ID: 3557

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Bioluminescent imaging in adult zebrafish 02
Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. In this image, a... more
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Bioluminescent imaging in adult zebrafish 01
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ID: 3556

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Bioluminescent imaging in adult zebrafish 01
Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. In this image, a... more
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Protein clumping in zinc-deficient yeast cells
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ID: 3550

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Protein clumping in zinc-deficient yeast cells
The green spots in this image are clumps of protein inside yeast cells that are deficient in both zinc and a protein called Tsa1 that prevents clumpi... more
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TonB protein in gram-negative bacteria
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ID: 3549

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TonB protein in gram-negative bacteria
The green in this image highlights a protein called TonB, which is produced by many gram-negative bacteria, including those that cause typhoid fever,... more
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Master clock of the mouse brain
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ID: 3547

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Master clock of the mouse brain
An image of the area of the mouse brain that serves as the 'master clock,' which houses the brain's time-keeping neurons. The nuclei of the clock cel... more
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Insulin and protein interact in pancreatic beta cells
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ID: 3546

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Insulin and protein interact in pancreatic beta cells
A large number of proteins interact with the hormone insulin as it is produced in and scereted from the beta cells of the pancreas. In this image, th... more
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Structure of amyloid-forming prion protein
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ID: 3542

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Structure of amyloid-forming prion protein
This structure from an amyloid-forming prion protein shows one way beta sheets can stack. Image originally appeared in a December 2012 PLOS Biology p... more
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Cell in two stages of division
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ID: 3541

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Cell in two stages of division
This image shows a cell in two stages of division: prometaphase (top) and metaphase (bottom). To form identical daughter cells, chromosome pairs (blu... more
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Structure of heme, side view
Illustration
ID: 3540

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Structure of heme, side view
Molecular model of the struture of heme. Heme is a small, flat molecule with an iron ion (dark red) at its center. Heme is an essential component of ... more
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Structure of heme, top view
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ID: 3539

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Structure of heme, top view
Molecular model of the struture of heme. Heme is a small, flat molecule with an iron ion (dark red) at its center. Heme is an essential component of ... more
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Lorsch Swearing In
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ID: 3530

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Lorsch Swearing In
Jon Lorsch at his swearing in as NIGMS director in August 2013. Also shown are Francis Collins, NIH Director, and Judith Greenberg, former NIGMS Acti... more
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Bacteria in the mouse colon
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ID: 3527

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Bacteria in the mouse colon
Image of the colon of a mouse mono-colonized with Bacteroides fragilis (red) residing within the crypt channel. The red staining is due to an antibod... more
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800 MHz NMR magnet
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ID: 3526

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800 MHz NMR magnet
Scientists use nuclear magnetic spectroscopy (NMR) to determine the detailed, 3D structures of molecules.
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Bacillus anthracis being killed
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ID: 3525

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Bacillus anthracis being killed
Bacillus anthracis (anthrax) cells being killed by a fluorescent trans-translation inhibitor, which disrupts bacterial protein synthesis. The inhibit... more
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HeLa cells
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ID: 3522

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HeLa cells
Multiphoton fluorescence image of cultured HeLa cells with a fluorescent protein targeted to the Golgi apparatus (orange), microtubules (green) and c... more
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HeLa cells
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ID: 3521

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HeLa cells
Multiphoton fluorescence image of HeLa cells stained with the actin binding toxin phalloidin (red), microtubules (cyan) and cell nuclei (blue). Niko... more
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HeLa cells
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ID: 3520

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HeLa cells
Multiphoton fluorescence image of HeLa cells with cytoskeletal microtubules (magenta) and DNA (cyan). Nikon RTS2000MP custom laser scanning microsco... more
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HeLa cells
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ID: 3519

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HeLa cells
Scanning electron micrograph of an apoptotic HeLa cell. Zeiss Merlin HR-SEM.
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HeLa cells
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ID: 3518

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HeLa cells
Scanning electron micrograph of just-divided HeLa cells. Zeiss Merlin HR-SEM.
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Neuron with labeled synapses
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ID: 3509

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Neuron with labeled synapses
In this image, recombinant probes known as FingRs (Fibronectin Intrabodies Generated by mRNA display) were expressed in a cortical neuron, where they... more
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Wound healing in process
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ID: 3500

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Wound healing in process
Wound healing requires the action of stem cells. In mice that lack the Sept2/ARTS gene, stem cells involved in wound healing live longer and wounds h... more
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Growing hair follicle stem cells
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ID: 3499

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Growing hair follicle stem cells
Wound healing requires the action of stem cells. In mice that lack the Sept2/ARTS gene, stem cells involved in wound healing live longer and wounds h... more
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Wound healing in process
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ID: 3498

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Wound healing in process
Wound healing requires the action of stem cells. In mice that lack the Sept2/ARTS gene, stem cells involved in wound healing live longer and wounds h... more
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Wound healing in process
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ID: 3497

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Wound healing in process
Wound healing requires the action of stem cells. In mice that lack the Sept2/ARTS gene, stem cells involved in wound healing live longer and wounds h... more
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How cilia do the wave
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ID: 3494

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How cilia do the wave
Thin, hair-like biological structures called cilia are tiny but mighty. Each one, made up of more than 600 different proteins, works together with hu... more
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Repairing DNA
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ID: 3493

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Repairing DNA
Like a watch wrapped around a wrist, a special enzyme encircles the double helix to repair a broken strand of DNA. Without molecules that can mend su... more
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Glowing bacteria make a pretty postcard
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ID: 3492

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Glowing bacteria make a pretty postcard
A petri dish full of bacteria -- genetically engineered glowing bacteria -- looks like it could grace the front of a postcard from Key West.
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Kinesin moves cellular cargo
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ID: 3491

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Kinesin moves cellular cargo
A protein called kinesin (blue) is in charge of moving cargo around inside cells and helping them divide. It's powered by biological fuel called ATP ... more
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Brains of sleep-deprived and well-rested fruit flies
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ID: 3490

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Brains of sleep-deprived and well-rested fruit flies
On top, the brain of a sleep-deprived fly glows orange because of Bruchpilot, a communication protein between brain cells. These bright orange brain ... more
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Worm sperm
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ID: 3489

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Worm sperm
To develop a system for studying cell motility in unnatrual conditions -- a microscope slide instead of the body -- Tom Roberts and Katsuya Shimabuku... more
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Shiga toxin being sorted inside a cell
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ID: 3488

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Shiga toxin being sorted inside a cell
Shiga toxin (green) is sorted from the endosome into membrane tubules (red), which then pinch off and move to the Golgi apparatus.
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Ion channel
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ID: 3487

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Ion channel
A special "messy" region of a potassium ion channel is important in its function.
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Apoptosis reversed
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ID: 3486

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Apoptosis reversed
Two healthy cells (bottom, left) enter into apoptosis (bottom, center) but spring back to life after a fatal toxin is removed (bottom, right; top).
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Flatworm stem cells
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ID: 3485

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Flatworm stem cells
Flatworms' stem cells and excretory organs could provide insight into our own -- and pave the way toward regenerative therapies.
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Telomeres on outer edge of nucleus during cell division
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ID: 3484

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Telomeres on outer edge of nucleus during cell division
New research shows telomeres moving to the outer edge of the nucleus after cell division, suggesting these caps that protect chromosomes also may pla... more
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Chang Shan
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ID: 3483

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Chang Shan
For thousands of years, Chinese herbalists have treated malaria using Chang Shan, a root extract from a type of hydrangea that grows in Tibet and Nep... more
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Bacillus anthracis being killed
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ID: 3481

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Bacillus anthracis being killed
Bacillus anthracis (anthrax) cells being killed by a fluorescent trans-translation inhibitor, which disrupts bacterial protein synthesis. The inhibit... more
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Cancer Cells Glowing from Luciferin
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ID: 3480

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Cancer Cells Glowing from Luciferin
The activator cancer cell culture, right, contains a chemical that causes the cells to emit light when in the presence of immune cells.
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Electrode probe on mouse Huntington's muscle cell
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ID: 3479

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Electrode probe on mouse Huntington's muscle cell
Using an electrode, researchers apply an electrical pulse onto a piece of muscle tissue affected by Huntington's disease.
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DDR2 Receptors Attach to Collagen in Breast Tumor
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ID: 3478

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DDR2 Receptors Attach to Collagen in Breast Tumor
On the left, the boundary of a breast tumor (yellow) attaches to collagen fibers that are closest to it (green) using DDR2. On the right, a tumor wit... more
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HIV Capsid
Illustration
ID: 3477

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HIV Capsid
This image is a computer-generated model of the approximately 4.2 million atoms of the HIV capsid, the shell that contains the virus' genetic materia... more
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Automated Worm Sorter - 4
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ID: 3475

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Automated Worm Sorter - 4
Georgia Tech associate professor Hang Lu holds a microfluidic chip that is part of a system that uses artificial intelligence and cutting-edge image ... more
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Prion protein fibrils 1
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ID: 3460

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Prion protein fibrils 1
Recombinant proteins such as the prion protein shown here are often used to model how proteins misfold and sometimes polymerize in neurodegenerative ... more
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Structure of telomerase
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ID: 3459

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Structure of telomerase
Scientists recently discovered the full molecular structure of telomerase, an enzyme important to aging and cancer. Within each cell, telomerase main... more
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Computer algorithm
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ID: 3458

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Computer algorithm
This computer algorithm plots all feasible small carbon-based molecules as though they were cities on a map and identifies huge, unexplored spaces th... more
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Sticky stem cells
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ID: 3457

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Sticky stem cells
Like a group of barnacles hanging onto a rock, these human cells hang onto a matrix coated glasss slide. Actin stress fibers, stained magenta, and th... more
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Proteasome
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ID: 3451

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Proteasome
This fruit fly spermatid recycles various molecules, including malformed or damaged proteins. Actin filaments (red) in the cell draw unwanted protein... more
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Calcium uptake during ATP production in mitochondria
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ID: 3449

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Calcium uptake during ATP production in mitochondria
Living primary mouse embryonic fibroblasts. Mitochondria (green) stained with the mitochondrial membrane potential indicator, rhodamine 123. Nuclei (... more
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Dynamin Fission
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ID: 3448

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Dynamin Fission
Time lapse series shows short dynamin assemblies (not visible) constricting a lipid tube to make a "beads on a string" appearance, then cutting off o... more
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Biofilm blocking fluid flow
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ID: 3446

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Biofilm blocking fluid flow
This time-lapse movie shows that bacterial communities called biofilms can create blockages that prevent fluid flow in devices such as stents and cat... more
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Dividing Cell in Metaphase
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ID: 3445

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Dividing Cell in Metaphase
This image of a mammalian epithelial cell, captured in metaphase, was the winning image in the high- and super-resolution microscopy category of the ... more
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Taste Buds
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ID: 3444

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Taste Buds
Taste buds in a circumvallate papilla in a mouse tongue with types I, II and III taste cells visualized by cell-type-specific fluorescent antibodies.... more
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Interphase in Xenopus frog cells
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ID: 3443

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Interphase in Xenopus frog cells
These images show frog cells in interphase. The cells are Xenopus XL177 cells, which are derived from tadpole epithelial cells. The microtubules are ... more
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Cell division phases in Xenopus frog cells
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ID: 3442

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Cell division phases in Xenopus frog cells
These images show three stages of cell division in Xenopus XL177 cells, which are derived from tadpole epithelial cells. They are (from top): metapha... more
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Transcription factor Sox17 controls embryonic development of certain internal organs
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ID: 3440

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Transcription factor Sox17 controls embryonic development of certain internal organs
During embryonic development, transcription factors (proteins that regulate gene expression) govern the differentiation of cells into separate tissue... more
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NIGMS overview
Video
ID: 3439

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NIGMS overview
Highlights NIGMS-supported research areas and training programs. http://publications.nigms.nih.gov/multimedia/video/nigms-overview.html
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Morphine Structure
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ID: 3438

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Morphine Structure
The chemical structure of the morphine molecule
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Network diagram of genes, cellular components and processes (labeled)
Illustration
ID: 3437

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Network diagram of genes, cellular components and processes (labeled)
This image shows the hierarchical ontology of genes, cellular components and processes derived from large genomic datasets. From Dutkowski et al. A g... more
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Network diagram of genes, cellular components and processes (unlabeled)
Illustration
ID: 3436

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Network diagram of genes, cellular components and processes (unlabeled)
This image shows the hierarchical ontology of genes, cellular components and processes derived from large genomic datasets. From Dutkowski et al. A g... more
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Flu virus proteins during self-replication
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ID: 3434

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Flu virus proteins during self-replication
Influenza (flu) virus proteins in the act of self-replication. Viral nucleoprotein (blue) encapsidates [encapsulates] the RNA genome (green). The inf... more
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Mouse mammary cells lacking anti-cancer protein
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ID: 3432

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Mouse mammary cells lacking anti-cancer protein
Shortly after a pregnant woman gives birth, her breasts start to secrete milk. This process is triggered by hormonal and genetic cues, including the ... more
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Enzyme transition states
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ID: 3429

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Enzyme transition states
The molecule on the left is an electrostatic potential map of the van der Waals surface of the transition state for human purine nucleoside phosphory... more
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Antitoxin GhoS_2
Illustration
ID: 3428

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Antitoxin GhoS_2
Structure of the bacterial antitoxin protein GhoS. GhoS inhibits the production of a bacterial toxin, GhoT, which can contribute to antibiotic resist... more
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Antitoxin GhoS_1
Illustration
ID: 3427

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Antitoxin GhoS_1
Structure of the bacterial antitoxin protein GhoS. GhoS inhibits the production of a bacterial toxin, GhoT, which can contribute to antibiotic resist... more
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Regeneration of Mouse Ears
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ID: 3426

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Regeneration of Mouse Ears
Normal mice, like the B6 breed pictured on the left, develop scars when their ears are pierced. The Murphy Roths Large (MRL) mice pictured on the rig... more
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Red Poppy
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ID: 3425

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Red Poppy
A red poppy.
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White Poppy
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ID: 3424

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White Poppy
A white poppy.
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White Poppy (cropped)
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ID: 3423

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White Poppy (cropped)
A white poppy.
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Atomic Structure of Poppy Enzyme
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ID: 3422

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Atomic Structure of Poppy Enzyme
The atomic structure of the morphine biosynthetic enzyme salutaridine reductase bound to the cofactor NADPH. The substrate salutaridine is shown ente... more
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Structure of Glutamate Dehydrogenase
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ID: 3421

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Structure of Glutamate Dehydrogenase
Some children are born with a mutation in a regulatory site on this enzyme that causes them to over-secrete insulin when they consume protein. We fou... more
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 7
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ID: 3419

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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 7
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (20... more
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 6
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ID: 3418

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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 6
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (20... more
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 5
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ID: 3417

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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 5
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (20... more
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 4
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ID: 3416

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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 4
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (20... more
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 3
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ID: 3415

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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 3
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (20... more
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 2
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ID: 3414

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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 2
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (20... more
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 1
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ID: 3413

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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 1
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (20... more
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Active Site of E. coli response regulator PhoB
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ID: 3412

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Active Site of E. coli response regulator PhoB
Active Site of E. coli response regulator PhoB
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O2 reacting with a flavin-dependent enzyme
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ID: 3411

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O2 reacting with a flavin-dependent enzyme
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Kluyveromyces polysporus Argonaute bound to guide RNA
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ID: 3408

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Kluyveromyces polysporus Argonaute bound to guide RNA
A segment of siRNA, shown in red, guides a "slicer" protein called Argonaute (multi-colored twists and corkscrews) to the target RNA molecules.
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LincRNA and gene regulatory proteins
Illustration
ID: 3407

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LincRNA and gene regulatory proteins
A LincRNA molecule, shown in red, serves as a scaffold for gene regulatory proteins, shown in grey. The DNA is represented as a grey double helix.
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Phenylalanine tRNA molecule
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ID: 3406

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Phenylalanine tRNA molecule
Phenylalanine tRNA showing the anticodon (yellow) and the amino acid, phenylalanine (blue and red spheres). The structure of phenylalanine tRNA is de... more
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Disrupted and restored vasculature development in frog embryos
Video
ID: 3405

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Disrupted and restored vasculature development in frog embryos
Disassembly of vasculature and reassembly after addition and then washout of 250 µM TBZ in kdr:GFP frogs.
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Normal vascular development in frog embryos
Video
ID: 3404

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Normal vascular development in frog embryos
In vivo vascular development in kdr:GFP frogs.
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Disrupted vascular development in frog embryos
Video
ID: 3403

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Disrupted vascular development in frog embryos
Disassembly of vasculature in kdr:GFP frogs following addition of 250 µM TBZ.
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Hsp33 Heat Shock Protein Inactive to Active
Video
ID: 3402

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Hsp33 Heat Shock Protein Inactive to Active
When the heat shock protein hsp33 is folded, it is inactive and contains a zinc ion, stabilizing the redox sensitive domain (orange). In the presenc... more
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Small blood vessels in a mouse retina
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ID: 3400

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Small blood vessels in a mouse retina
Blood vessels at the back of the eye (retina) are used to diagnose glaucoma and diabetic eye disease. They also display characteristic changes in peo... more
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Synapses in culture
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ID: 3399

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Synapses in culture
Cultured hippocampal neurons grown on a substrate of glial cells (astrocytes). The glial cells form the pink/brown underlayment in this image. The ta... more
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Myelinated axons 2
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ID: 3397

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Myelinated axons 2
Top view of myelinated axons in a rat spinal root. Myelin is a type of fat that forms a sheath around and thus insulates the axon to protect it from ... more
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Myelinated axons 1
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ID: 3396

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Myelinated axons 1
Myelinated axons in a rat spinal root. Myelin is a type of fat that forms a sheath around and thus insulates the axon to protect it from losing the e... more
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NCMIR mouse tail
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ID: 3395

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NCMIR mouse tail
Stained cross section of the mouse tail.
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NCMIR Kidney Glomeruli
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ID: 3392

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NCMIR Kidney Glomeruli
Stained glomeruli in the kidney. The kidney is an essential organ responsible for disposing wastes from the body and for maintaining healthy ion leve... more
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Protein folding video
Video
ID: 3391

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Protein folding video
Proteins are long chains of amino acids. Each protein has a unique amino acid sequence. It is still a mystery how a protein folds into the proper sha... more
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NCMIR Intestine-2
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ID: 3390

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NCMIR Intestine-2
The small intestine is where most of our nutrients from the food we eat are absorbed into the bloodstream. The walls of the intestine contain small f... more
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NCMIR Intestine-1
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ID: 3389

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NCMIR Intestine-1
The small intestine is where most of our nutrients from the food we eat are absorbed into the bloodstream. The walls of the intestine contain small f... more
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NCMIR human spinal nerve
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ID: 3387

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NCMIR human spinal nerve
Spinal nerves are part of the peripheral nervous system. They run within the spinal column to carry nerve signals to and from all parts of the body. ... more
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HIV Infected Cell
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ID: 3386

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HIV Infected Cell
The human immunodeficiency virus (HIV),shown here as tiny purple spheres, causes the disease known as AIDS (for acquired immunodeficiency syndrome). ... more
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Electrostatic map of the adeno-associated virus with scale
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ID: 3375

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Electrostatic map of the adeno-associated virus with scale
The new highly efficient parallelized DelPhi software was used to calculate the potential map distribution of an entire virus, the adeno-associated v... more
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Electrostatic map of the adeno-associated virus
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ID: 3374

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Electrostatic map of the adeno-associated virus
The new highly efficient parallelized DelPhi software was used to calculate the potential map distribution of an entire virus, the adeno-associated v... more
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Mouse cerebellum close up
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ID: 3371

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Mouse cerebellum close up
The cerebellum is the brain's locomotion control center. Every time you shoot a basketball, tie your shoe or chop an onion, your cerebellum fires int... more
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Chemokine CXCR4 receptor
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ID: 3365

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Chemokine CXCR4 receptor
The receptor is shown bound to a small molecule peptide called CVX15.
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Nociceptin/orphanin FQ peptide opioid receptor
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ID: 3364

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Nociceptin/orphanin FQ peptide opioid receptor
The receptor is shown bound to an antagonist, compound-24
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Dopamine D3 receptor
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ID: 3363

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Dopamine D3 receptor
The receptor is shown bound to an antagonist, eticlopride
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Sphingolipid S1P1 receptor
Illustration
ID: 3362

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Sphingolipid S1P1 receptor
The receptor is shown bound to an antagonist, ML056.
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A2A adenosine receptor
Illustration
ID: 3361

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A2A adenosine receptor
The receptor is shown bound to an inverse agonist, ZM241385.
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H1 histamine receptor
Illustration
ID: 3360

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H1 histamine receptor
The receptor is shown bound to an inverse agonist, doxepin.
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Kappa opioid receptor
Illustration
ID: 3359

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Kappa opioid receptor
The receptor is shown bound to an antagonist, JDTic.
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Beta 2-adrenergic receptor
Illustration
ID: 3358

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Beta 2-adrenergic receptor
The receptor is shown bound to a partial inverse agonist, carazolol
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Hsp33 figure 2
Illustration
ID: 3355

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Hsp33 figure 2
Featured in the March 15, 2012 issue of Biomedical Beat. Related to Hsp33 Figure 1, image 3354.
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Hsp33 figure 1
Illustration
ID: 3354

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Hsp33 figure 1
Featured in the March 15, 2012 issue of Biomedical Beat. Related to Hsp33 Figure 2, image 3355.
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Judith Greenberg 50th Anniversary Pose_2
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ID: 3352

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Judith Greenberg 50th Anniversary Pose_2
Photo of Dr. Judith Greenberg, Acting Director of the National Institute of General Medical Sciences during the organization's 50th anniversary (2012... more
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Judith Greenberg 50th Anniversary Pose_1
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ID: 3351

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Judith Greenberg 50th Anniversary Pose_1
Photo of Dr. Judith Greenberg, Acting Director of the National Institute of General Medical Sciences during the organization's 50th anniversary (2012... more
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Artificial cilia exhibit spontaneous beating
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ID: 3344

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Artificial cilia exhibit spontaneous beating
Researchers have created artificial cilia that wave like the real thing. Zvonimir Dogic and his Brandeis University colleagues combined just a few ci... more
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Suicidal Stem Cells
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ID: 3341

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Suicidal Stem Cells
Embryonic stem cells store pre-activated Bax (red) in the Golgi, near the nucleus (blue) Featured in the June 21, 2012, issue of Biomedical Beat.
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Mitotic spindle-chromosome
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ID: 3340

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Mitotic spindle-chromosome
Chromosome attachments (green) to the mitotic spindle (red) shown in a dividing human cell. Related information in news release.
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Single-Molecule Imaging
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ID: 3339

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Single-Molecule Imaging
This is a super-resolution LM image taken by Hiro Hakozaki and Masa Hoshijima of NCMIR. The image contains highlighted calcium channels in cardiac mu... more
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Four timepoints in gastrulation
Video
ID: 3334

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Four timepoints in gastrulation
It has been said that gastrulation is the most important event in a person's life. This part of early embryonic development transforms a simple ball ... more
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Polarized cells- 02
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ID: 3333

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Polarized cells- 02
Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a comple... more
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Polarized cells- 01
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ID: 3332

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Polarized cells- 01
Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a comple... more
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mDia1 antibody staining- 02
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ID: 3331

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mDia1 antibody staining- 02
Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a comple... more
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mDia1 antibody staining-01
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ID: 3330

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mDia1 antibody staining-01
Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a comple... more
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