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6985886<em> Drosophila </em> adult brain showing that an adipokine (fat hormone) generates a response from neurons (aqua) and regulates insulin-producing neurons (red). <Br><Br>Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6982">6982</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6983">6983</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6984">6984</a>.12/19/2023 9:06:13 PM12/19/2023 9:06:13 PMType    Name    Media Type    File Size    Modified Since the images are too large to attach I have uploaded them at this google drive link and you should be able to download it the link STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx301100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B16A02E1-AF2B-43FE-A6EC-37FF25432F66}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6982932Fourteen neurons (magenta) in the adult <em> Drosophila </em> brain produce insulin, and fat tissue sends packets of lipids to the brain via the lipoprotein carriers (green). This image was captured using a confocal microscope and shows a maximum intensity projection of many slices. <Br><Br>Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6983">6983</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6984">6984</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6985">6985</a>.12/19/2023 7:12:13 PM12/19/2023 7:12:13 PMType    Name    Media Type    File Size    Modified #1_Dilp ApoII_M    Medium 320 KB 12/19/2023 2:13 PM Crowley, Rachel (NIH/NIGMS) [E Please let me know if you STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx32190https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{6519601A-B4F6-4AFB-89E6-4BA77ECF4F0A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
127894Two models for how material passes through the Golgi apparatus: the vesicular shuttle model and the cisternae maturation model. You can see animations of the two different models at <a href="http://publications.nigms.nih.gov/insidethecell/extras/" target="_blank">http://publications.nigms.nih.gov/insidethecell/extras/</a>. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.10/28/2020 4:37:04 PM10/28/2020 4:37:04 PMType    Name    Media Type    File Size    Modified ITC_GolgiTheories_S    Low 69 KB 8/24/2016 5:17 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx274320https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{8338FE7B-DE3A-4BB1-9AD3-842F7470380D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2607547This eerily glowing blob isn't an alien or a creature from the deep sea--it's a mouse embryo just eight and a half days old. The green shell and core show a protein called Smad4. In the center, Smad4 is telling certain cells to begin forming the mouse's liver and pancreas. Researchers identified a trio of signaling pathways that help switch on Smad4-making genes, starting immature cells on the path to becoming organs. The research could help biologists learn how to grow human liver and pancreas tissue for research, drug testing and regenerative medicine. In addition to NIGMS, NIH's National Institute of Diabetes and Digestive and Kidney Diseases also supported this work. Featured in the July 15, 2009, issue of <a href=http://publications.nigms.nih.gov/biobeat/09-07-15/index.html#1 target="_blank"><em>Biomedical Beat</em></a>.10/30/2020 9:25:44 PM10/30/2020 9:25:44 PMType    Name    Media Type    File Size    Modified mouse_embryo    High 184 KB 6/3/2016 3:14 PM aamishral2 (NIH/NIGMS) [C This eerily glowing blob isn't an STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13780https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{01CB437C-0A25-49DB-B6CA-F92DE2A34176}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
127592The Golgi complex, also called the Golgi apparatus or, simply, the Golgi. This organelle receives newly made proteins and lipids from the ER, puts the finishing touches on them, addresses them, and sends them to their final destinations. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.10/28/2020 4:29:29 PM10/28/2020 4:29:29 PMType    Name    Media Type    File Size    Modified ITC_Golgi_inset_Copy_M    Medium 28 KB 10/28/2020 12:29 PM McCulley, Jennifer (NIH/NIDCD) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx4246270https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F1ACB139-25A3-4C54-8EE3-575084FC6DB6}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6611864Circadian rhythms are physical, mental, and behavioral changes that follow a 24-hour cycle. Typical circadian rhythms lead to high energy during the middle of the day (10 a.m. to 1 p.m.) and an afternoon slump. At night, circadian rhythms cause the hormone melatonin to rise, making a person sleepy. <Br><Br> Learn more in NIGMS’ circadian rhythms <a href="https://www.nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx">featured topics page</a>. <Br><Br>See <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6612">6612</a> for the Spanish version of this infographic. 1/5/2024 4:54:05 PM1/5/2024 4:54:05 PMType    Name    Media Type    File Size    Modified CR_TeenTimeline_Opt3B_M    Medium 343 KB 2/12/2021 9:29 AM Walter, Taylor (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx395510https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{824D535B-F568-41B6-99E0-0EFFC580F9A2}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3719816This illustration shows, in simplified terms, how the CRISPR-Cas9 system can be used as a gene-editing tool. The illustration includes a cartoon with four frames and a fifth frame with potential applications. For an explanation and overview of the CRISPR-Cas9 system, see the NIGMS Biomedical Beat blog entry at https://biobeat.nigms.nih.gov/2014/09/field-focus-precision-gene-editing-with-crispr/ and the iBiology video at http://www.ibiology.org/ibiomagazine/jennifer-doudna-genome-engineering-with-crispr-cas9-birth-of-a-breakthrough-technology.html.8/12/2024 3:52:02 PM8/12/2024 3:52:02 PMType    Name    Media Type    File Size    Modified CRISPR_Illustrations_2015    High 391 KB 2/5/2019 4:10 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx419700https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{8ADE9DDC-DC6D-4823-A1CC-7FF33FC2C0A6}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2314306A nanometer-sized biosensor can detect a single deadly bacterium in tainted ground beef. How? Researchers attached nanoparticles, each packed with thousands of dye molecules, to an antibody that recognizes the microbe <i>E. coli</i> O157:H7. When the nanoball-antibody combo comes into contact with the <i>E. coli</i> bacterium, it glows. Here is the transition, a single bacterial cell glows brightly when it encounters nanoparticle-antibody biosensors, each packed with thousands of dye molecules. Featured in the March 15, 2005, issue of <a href=http://publications.nigms.nih.gov/biobeat/05-09-20/#1 target="_blank"><em>Biomedical Beat</em></a>.10/29/2020 1:07:28 PM10/29/2020 1:07:28 PMType    Name    Media Type    File Size    Modified finding_one_bug_M    Medium 11 KB 6/3/2016 3:08 PM aamishral2 (NIH/NIGMS) [C Here is the transition, a single STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15370https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{A742553F-0939-4A2D-8318-60ED0CBE57D3}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2382318Model of an enzyme, PanB, from <i>Mycobacterium tuberculosis</i>, the bacterium that causes most cases of tuberculosis. This enzyme is an attractive drug target.10/29/2020 4:47:27 PM10/29/2020 4:47:27 PMType    Name    Media Type    File Size    Modified 2382_hi_Rv2878c_S    Low 132 KB 3/29/2019 11:30 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx385170https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{DC5A3220-467F-4065-89A1-7F4715ADC056}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2339114NMR solution structure of a plant protein that may function in host defense. This protein was expressed in a convenient and efficient wheat germ cell-free system. Featured as the June 2007 Protein Structure Initiative Structure of the Month.10/29/2020 2:40:04 PM10/29/2020 2:40:04 PMType    Name    Media Type    File Size    Modified hi_2g02_L    Low 70 KB 6/3/2016 3:09 PM aamishral2 (NIH/NIGMS) [C Featured as the June 2007 Protein Structure STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx19060https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{47234FEB-EE1D-4DF6-A666-446A5C2D9E37}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6548894Cilia (cilium in singular) are complex molecular machines found on many of our cells. One component of cilia is the doublet microtubule, a major part of cilia’s skeletons that give them support and shape. This animated image is a partial model of a doublet microtubule’s structure based on cryo-electron microscopy images. Video can be found here <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6549"> 6549. </a>12/22/2020 3:28:03 PM12/22/2020 3:28:03 PMType    Name    Media Type    File Size    Modified 18046_Axoneme_Still_Watermark_Thumb    Thumbnail 39 KB 3/19/2020 3:12 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15760https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B48B9B01-3F87-4F01-8650-EE6F89E59501}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2549341DNA encodes RNA, which encodes protein. DNA is transcribed to make messenger RNA (mRNA). The mRNA sequence (dark red strand) is complementary to the DNA sequence (blue strand). On ribosomes, transfer RNA (tRNA) reads three codons at a time in mRNA to bring together the amino acids that link up to make a protein. See image 2548 for a version of this illustration that isn't numbered and 2547 for a an entirely unlabeled version. Featured in <a href=http://publications.nigms.nih.gov/thenewgenetics/ target="_blank"><i>The New Genetics</i></a>.5/13/2024 6:31:53 PM5/13/2024 6:31:53 PMType    Name    Media Type    File Size    Modified Translation_with_labels_and_stages_M    Medium 115 KB 7/27/2016 11:45 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx20360https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F31244A1-27B7-404B-8A4E-3E8E9AEE63E7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3576608Here, bubonic plague bacteria (yellow) are shown in the digestive system of a rat flea (purple). The bubonic plague killed a third of Europeans in the mid-14th century. Today, it is still active in Africa, Asia and the Americas, with as many as 2,000 people infected worldwide each year. If caught early, bubonic plague can be treated with antibiotics. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.11/28/2022 9:43:00 PM11/28/2022 9:43:00 PMType    Name    Media Type    File Size    Modified Yersina_pestis_1_H    High 4674 KB 10/5/2020 2:04 AM Harris, Donald (NIH/NIGMS) [C Br><Br> This image was part of the <em STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx18360https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1DA06FC3-2FA7-4A59-B108-BBB3DD8ACB3F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3286578This color-enhanced image is a scanning electron microscope image of retinal pigment epithelial cells derived from human embryonic stem cells. The cells are remarkably similar to normal RPE cells, growing in a hexagonal shape in a single, well-defined layer. This kind of retinal cell is responsible for macular degeneration, the most common cause of blindness. Image and caption information courtesy of the California Institute for Regenerative Medicine.12/22/2020 10:48:39 PM12/22/2020 10:48:39 PMType    Name    Media Type    File Size    Modified Retinalpigmentepithelium_L    Low 9 KB 6/3/2016 3:25 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14260https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{7116733A-E578-48FC-86C7-7D0220C2C55A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2714420Muscles stretch and contract when we walk, and skin splits open and knits back together when we get a paper cut. To study these contractile forces, researchers built a three-dimensional scaffold that mimics tissue in an organism. Researchers poured a mixture of cells and elastic collagen over microscopic posts in a dish. Then they studied how the cells pulled and released the posts as they formed a web of tissue. To measure forces between posts, the researchers developed a computer model. Their findings--which show that contractile forces vary throughout the tissue--could have a wide range of medical applications. Featured in the October 21, 2009 issue of <a href=http://publications.nigms.nih.gov/biobeat/09-10-21/#1 target="_blank"><i>Biomedical Beat</i></a>.8/6/2020 4:55:28 PM8/6/2020 4:55:28 PMType    Name    Media Type    File Size    Modified Stretch_detectors    High 5125 KB 6/3/2016 3:16 PM aamishral2 (NIH/NIGMS) [C Then they studied how the cells STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13760https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{EEDB6932-20ED-41B9-AB1A-7B0B4B3B7D9B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6962977A <em>Trigonium</em> diatom imaged by a quantitative orientation-independent differential interference contrast (OI-DIC) microscope. Diatoms are single-celled photosynthetic algae with mineralized cell walls that contain silica and provide protection and support. These organisms form an important part of the plankton at the base of the marine and freshwater food chains. The width of this image is 90 μm. <Br><Br> More information about the microscopy that produced this image can be found in the <em>Journal of Microscopy</em> paper <a href="https://onlinelibrary.wiley.com/doi/10.1111/jmi.12682/">“An Orientation-Independent DIC Microscope Allows High Resolution Imaging of Epithelial Cell Migration and Wound Healing in a Cnidarian Model”</a> by Malamy and Shribak. 1/27/2023 9:46:30 PM1/27/2023 9:46:30 PMType    Name    Media Type    File Size    Modified Trigonium_M    Medium 692 KB 1/27/2023 4:29 PM Bigler, Abbey (NIH/NIGMS) [C The image width is 90 μm STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx243100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F78335F9-FB37-4883-9939-AEB00AE242F9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2606355The human skin cells pictured contain genetic modifications that make them pluripotent, essentially equivalent to embryonic stem cells. A scientific team from the University of Wisconsin-Madison including researchers Junying Yu, James Thomson, and their colleagues produced the transformation by introducing a set of four genes into human fibroblasts, skin cells that are easy to obtain and grow in culture.10/30/2020 7:29:57 PM10/30/2020 7:29:57 PMType    Name    Media Type    File Size    Modified skin_cell_pluripotent07_1.2_M    Medium 364 KB 7/27/2016 11:42 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17070https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F5E9431B-2DE0-44AA-BAE3-869CECE1EF36}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6968927The interior of a regenerating lizard tail 14 days after the original tail was amputated. Cell nuclei (blue), proliferating cells (green), cartilage (red), and muscle (white) have been visualized with immunofluorescence staining.1/30/2023 4:49:14 PM1/30/2023 4:49:14 PMType    Name    Media Type    File Size    Modified Regenerating Lizard Tail_S    Low 28 KB 1/30/2023 1:15 PM Bigler, Abbey (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx19770https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{17309D44-10BF-4515-AFBC-B63BFC46A7A1}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3628807This image shows the uncontrolled growth of cells in squamous cell carcinoma, the second most common form of skin cancer. If caught early, squamous cell carcinoma is usually not life-threatening. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.11/28/2022 9:26:27 PM11/28/2022 9:26:27 PMType    Name    Media Type    File Size    Modified 11B_1_skin_cancer_cells_schober_fuchs_M    Medium 254 KB 11/20/2020 5:27 PM Walter, Taylor (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14480https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{FA9CB4E6-B57C-4939-A28C-0211B61AB549}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3255506Human metaphase chromosomes are visible with fluoresence in vitro hybridization (FISH). Centromeric alpha satellite DNA (green) are found in the heterochromatin at each centromere. Immunofluorescence with CENP-A (red) shows the centromere-specific histone H3 variant that specifies the kinetochore.12/22/2020 5:01:54 PM12/22/2020 5:01:54 PMType    Name    Media Type    File Size    Modified GGS_image1__Peter_Warburton__3255_S    Low 74 KB 9/7/2016 2:01 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx18990https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{D0E6A44E-C25E-4BDC-810C-AC4C7C2A675B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6487657This illustration shows, in simplified terms, how the CRISPR-Cas9 system can be used as a gene-editing tool. The CRISPR system has two components joined together: a finely tuned targeting device (a small strand of RNA programmed to look for a specific DNA sequence) and a strong cutting device (an enzyme called Cas9 that can cut through a double strand of DNA). In this frame (3 of 4), the Cas9 enzyme cuts both strands of the DNA.<Br><Br>For an explanation and overview of the CRISPR-Cas9 system, see the <a href=" http://www.ibiology.org/ibiomagazine/jennifer-doudna-genome-engineering-with-crispr-cas9-birth-of-a-breakthrough-technology.html">iBiology video</a>, and find the full <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7036">CRIPSR illustration here</a>.8/12/2024 3:43:08 PM8/12/2024 3:43:08 PMType    Name    Media Type    File Size    Modified CRISPR_Frame_3_thumbnail_T    Thumbnail 69 KB 3/12/2019 3:04 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx344160https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{9EA08454-BE86-4613-AF3C-9D3D96BEEF18}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2564475To splice a human gene into a plasmid, scientists take the plasmid out of an E. coli bacterium, cut the plasmid with a restriction enzyme, and splice in human DNA. The resulting hybrid plasmid can be inserted into another E. coli bacterium, where it multiplies along with the bacterium. There, it can produce large quantities of human protein. See image 2565 for a labeled version of this illustration. Featured in <a href=http://publications.nigms.nih.gov/thenewgenetics/ target="_blank"><i>The New Genetics</i></a>.10/30/2020 3:11:06 PM10/30/2020 3:11:06 PMType    Name    Media Type    File Size    Modified Recombinant_DNA_S    Low 54 KB 8/24/2016 2:51 PM Varkala, Venkat (NIH/NIGMS) [C To splice a human gene into a STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx18490https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B9D570D4-A13C-475A-83F9-F67DEAF4A0A7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2527534A drug's life in the body. Medicines taken by mouth pass through the liver before they are absorbed into the bloodstream. Other forms of drug administration bypass the liver, entering the blood directly. See <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2528">image 2528</a> for a labeled version of this illustration. Featured in <a href=http://publications.nigms.nih.gov/medbydesign/ target="_blank"><i>Medicines By Design</i></a>.11/4/2021 7:07:50 PM11/4/2021 7:07:50 PMType    Name    Media Type    File Size    Modified A_Drugs_Life_S    Low 102 KB 6/3/2016 3:12 PM aamishral2 (NIH/NIGMS) [C A drug's life in the body STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx309110https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{BEA06F2F-9683-4E82-9C56-768444839212}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6991888In SARS-CoV-2, the virus that causes COVID-19, nucleocapsid is a complex molecule with many functional parts. One section folds into an RNA-binding domain, with a groove that grips a short segment of the viral genomic RNA. Another section folds into a dimerization domain that brings two nucleocapsid molecules together. The rest of the protein is intrinsically disordered, forming tails at each end of the protein chain and a flexible linker that connects the two structured domains. These disordered regions assist with RNA binding and orchestrate association of nucleocapsid dimers into larger assemblies that package the RNA in the small space inside virions. Nucleocapsid is in magenta and purple, and short RNA strands are in yellow. <Br><Br> Find these in the RCSB Protein Data Bank: <a href="https://www.rcsb.org/structure/7ACT">RNA-binding domain</a> (PDB entry 7ACT) and <a href="https://www.rcsb.org/structure/6WJI">Dimerization domain</a> (PDB entry 6WJI). 2/5/2024 1:50:50 PM2/5/2024 1:50:50 PMType    Name    Media Type    File Size    Modified SARS-CoV-2 Nucleocapsid Dimer_M    Medium 85 KB 2/2/2024 2:25 PM Crowley, Rachel (NIH/NIGMS) [E STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx22570https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{06F2CCDB-BE0B-4149-B06D-1F7BCBB56576}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3745628Serum albumin (SA) is the most abundant protein in the blood plasma of mammals. SA has a characteristic heart-shape structure and is a highly versatile protein. It helps maintain normal water levels in our tissues and carries almost half of all calcium ions in human blood. SA also transports some hormones, nutrients and metals throughout the bloodstream. Despite being very similar to our own SA, those from other animals can cause some mild allergies in people. Therefore, some scientists study SAs from humans and other mammals to learn more about what subtle structural or other differences cause immune responses in the body. <Br><Br>Related to entries <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=694"> 3744</a> and <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=696">3746</a> 12/17/2020 5:40:23 PM12/17/2020 5:40:23 PMType    Name    Media Type    File Size    Modified albumin-rainbow-mode33_L    Low 194 KB 6/3/2016 3:40 PM aamishral2 (NIH/NIGMS) [C Please let me know if you STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx210390https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{4CDB149D-EA57-443F-BAAE-4CBB0147A4E3}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2554346Ribonucleic acid (RNA) has a sugar-phosphate backbone and the bases adenine (A), cytosine (C), guanine (G), and uracil (U). See image 2554 for a labeled version of this illustration. Featured in <a href=http://publications.nigms.nih.gov/thenewgenetics/ target="_blank"><i>The New Genetics</i></a>.3/4/2022 7:36:33 PM3/4/2022 7:36:33 PMType    Name    Media Type    File Size    Modified 2554_RNA_S    Low 97 KB 3/29/2019 11:20 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx202120https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{53E4AF8E-ED64-4744-90A7-3C71D80809DF}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1339104The largest human cell (by volume) is the egg. Human eggs are 150 micrometers in diameter and you can just barely see one with a naked eye. In comparison, consider the eggs of chickens...or ostriches! Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.10/29/2020 12:07:34 PM10/29/2020 12:07:34 PMType    Name    Media Type    File Size    Modified ITC_EggComp02_M    Medium 116 KB 10/29/2020 8:07 AM McCulley, Jennifer (NIH/NIDCD) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx298120https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{D7E7FAF9-C908-4EF8-8A52-9B68E55C9939}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2429329The cytoskeleton (green) and DNA (purple) are highlighed in these cells by immunofluorescence.8/17/2020 9:36:09 PM8/17/2020 9:36:09 PMType    Name    Media Type    File Size    Modified Wittmann2_M    Medium 284 KB 9/7/2016 3:05 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx158120https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{3A889D00-8849-4CED-A940-48E94DD31348}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
6582996Three <i>C. elegans</i>, tiny roundworms, with a ribosomal protein glowing red and muscle fibers glowing green. Researchers used these worms to study a molecular pathway that affects aging. The ribosomal protein is involved in protein translation and may play a role in dietary restriction-induced longevity. Image created using confocal microscopy. <br>View single roundworm here <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6581">6581</a>. <br> View closeup of roundworms here <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6583">6583</a>.3/19/2021 8:20:52 PM3/19/2021 8:20:52 PMType    Name    Media Type    File Size    Modified ThreeWorms_M    Medium 49 KB 8/10/2020 8:39 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx13680https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{AFFC83D5-1CA9-4F1F-AB09-4C4B88D3E492}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2514210HIV is a retrovirus, a type of virus that carries its genetic material not as DNA but as RNA. Long before anyone had heard of HIV, researchers in labs all over the world studied retroviruses, tracing out their life cycle and identifying the key proteins the viruses use to infect cells. When HIV was identified as a retrovirus, these studies gave AIDS researchers an immediate jump-start. The previously identified viral proteins became initial drug targets. See images <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2513">2513</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2515">2515</a> for other versions of this illustration. Featured in <a href=http://publications.nigms.nih.gov/structlife/ target="_blank"><i>The Structures of Life</i></a>.9/25/2020 4:29:40 PM9/25/2020 4:29:40 PMType    Name    Media Type    File Size    Modified 2514_Life_of_an_AIDS_Virus_with_labels_T    Thumbnail 117 KB 4/19/2019 12:29 PM Constantinides, Stephen (NIH STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx154100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{7C26D3D2-FF70-420C-A0BC-1E2725806E59}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1021279A light microscope image of a cell from the endosperm of an African globe lily (<i>Scadoxus katherinae</i>). This is one frame of a time-lapse sequence that shows cell division in action. The lily is considered a good organism for studying cell division because its chromosomes are much thicker and easier to see than human ones. Staining shows microtubules in red and chromosomes in blue. Here, condensed chromosomes are clearly visible and lined up.5/9/2022 1:48:39 PM5/9/2022 1:48:39 PMType    Name    Media Type    File Size    Modified lilymit8_S    Low 12 KB 9/8/2016 2:40 PM Varkala, Venkat (NIH/NIGMS) [C A light microscope image of a cell from the endosperm of an African STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14860https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{043568AC-3AD1-48FD-97C9-60AB01D5A133}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67971012Yeast cells that abnormally accumulate cell wall material (blue) at their ends and, when preparing to divide, in their middles. This image was captured using wide-field microscopy with deconvolution. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6791">6791</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6792">6792</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6793">6793</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6794">6794</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6798">6798</a>, and videos <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6795">6795</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6796">6796</a>.7/17/2023 5:08:11 PM7/17/2023 5:08:11 PMType    Name    Media Type    File Size    Modified YeastCells7_S    Low 12 KB 3/8/2022 9:44 AM Bigler, Abbey (NIH/NIGMS) [C Some of them have one blue end, and STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx18460https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{DDA4D0F0-1444-48F3-91F8-795F76B0BC06}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2733358Early on, this <i>Arabidopsis</i> plant embryo picks sides: While one end will form the shoot, the other will take root underground. Short pieces of RNA in the bottom half (blue) make sure that shoot-forming genes are expressed only in the embryo's top half (green), eventually allowing a seedling to emerge with stems and leaves. Like animals, plants follow a carefully orchestrated polarization plan and errors can lead to major developmental defects, such as shoots above and below ground. Because the complex gene networks that coordinate this development in plants and animals share important similarities, studying polarity in <i>Arabidopsis</i>--a model organism--could also help us better understand human development. Featured in the April 21, 2010, issue of <a href=http://publications.nigms.nih.gov/biobeat/10-04-21/index.html#1 target="_blank"><em>Biomedical Beat</em></a>.8/12/2020 5:48:27 PM8/12/2020 5:48:27 PMType    Name    Media Type    File Size    Modified Arabidopsis    High 30 KB 6/3/2016 3:16 PM aamishral2 (NIH/NIGMS) [C Like animals, plants follow a carefully orchestrated polarization plan and errors can lead to major developmental defects, such as STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17360https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C2874526-938B-4961-ADB3-8FC981D7D983}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2574412This <A href="http://publications.nigms.nih.gov/news/releases/videos/ferguson_video_1.ram">video</A> (requires free <A href="http://www.real.com/freeplayer/?rppr=fed" target="_blank">RealPlayer</A>) shows an uncontrolled outbreak of transmissible avian flu among people living in Thailand. Red indicates new cases while green indicates areas where the epidemic has finished. The video shows the spread of infection and recovery over 300 days in Thailand and neighboring countries.1/20/2023 2:16:02 PM1/20/2023 2:16:02 PMType    Name    Media Type    File Size    Modified 2574_Simulation_of_uncontrolled_avian_flu_outbreak_T    Thumbnail 61 KB 3/29/2019 11:11 AM Constantinides STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx24960https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{754FD1A3-B488-4058-B114-A67AD7277B4C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2759497In the absence of the engulfment receptor Draper, salivary gland cells (light blue) persist in the thorax of a developing <i>Drosophila melanogaster</i> pupa. See image 2758 for a cross section of a normal pupa that does express Draper.8/21/2020 7:28:19 PM8/21/2020 7:28:19 PMType    Name    Media Type    File Size    Modified draper-mutant_S    Low 16 KB 9/14/2016 11:24 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14460https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{4A178706-B83E-481F-B939-8ACA0AB2C112}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3617611This image shows a normal fibroblast, a type of cell that is common in connective tissue and frequently studied in research labs. This cell has a healthy skeleton composed of actin (red) and microtubles (green). Actin fibers act like muscles to create tension and microtubules act like bones to withstand compression. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.11/22/2022 9:18:45 PM11/22/2022 9:18:45 PMType    Name    Media Type    File Size    Modified 5_right_Cell_keep_their_shape_with_actin_and_microtubules    Other 39578 KB 10/25/2020 9:47 PM Harris STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11260https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{D856BBEC-A16B-4798-982B-454A9289AC04}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3500790Wound healing requires the action of stem cells. In mice that lack the Sept2/ARTS gene, stem cells involved in wound healing live longer and wounds heal faster and more thoroughly than in normal mice. This confocal microscopy image from a mouse lacking the Sept2/ARTS gene shows a tail wound in the process of healing. See more information in the press release from Rockefeller University <a href="http://newswire.rockefeller.edu/2013/06/20/scientists-identify-gene-that-regulates-stem-cell-death-and-skin-regeneration/">(http://newswire.rockefeller.edu/2013/06/20/scientists-identify-gene-that-regulates-stem-cell-death-and-skin-regeneration/)</a> and the article in Science <a href="http://www.sciencemag.org/content/341/6143/286.abstract/"> (http://www.sciencemag.org/content/341/6143/286.abstract)</a>.<br<</br>Related to images 3497 and 3498.9/10/2020 3:29:16 PM9/10/2020 3:29:16 PMType    Name    Media Type    File Size    Modified Steller4    Other 884 KB 9/26/2020 10:43 PM Harris, Donald (NIH/NIGMS) [C In mice that lack the Sept2/ARTS STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx18360https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{796B0EB8-8631-4FAD-9881-4789DF4C19D1}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67991014A sensor particle being engulfed by a macrophage—an immune cell—and encapsuled in a compartment called a phagosome. The phagosome then fuses with lysosomes—another type of compartment. The left video shows snowman-shaped sensor particles with fluorescent green nanoparticle “heads” and “bodies” colored red by Förster Resonance Energy Transfer (FRET)-donor fluorophores. The middle video visualizes light blue FRET signals that are only generated when the “snowman” sensor—the FRET-donor—fuses with the lysosomes, which are loaded with FRET-acceptors. The right video combines the other two. The videos were captured using epi-fluorescence microscopy. <Br><Br> More details can be found in the paper <a href="https://www.biorxiv.org/content/10.1101/2021.04.04.438376v1">“Transport motility of phagosomes on actin and microtubules regulates timing and kinetics of their maturation” </a> by Yu et al. 8/18/2023 12:41:12 PM8/18/2023 12:41:12 PMType    Name    Media Type    File Size    Modified Phagosome-H    High 1458 KB 1/21/2022 2:41 PM Dolan, Lauren (NIH/NIGMS) [C The right video combines the other STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14860https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{FBED8868-316B-4C74-A5D3-D7FF87A8A80D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68011016A macrophage—a type of immune cell that engulfs invaders—“eats” and is activated by a “two-faced” Janus particle. The particle is called “two-faced” because each of its two hemispheres is coated with a different type of molecule, shown here in red and cyan. During macrophage activation, a transcription factor tagged with a green fluorescence protein (NF-κB) gradually moves from the cell’s cytoplasm into its nucleus and causes DNA transcription. The distribution of molecules on “two-faced” Janus particles can be altered to control the activation of immune cells. Details on this “geometric manipulation” strategy can be found in the <em> Proceedings of the National Academy of Sciences</em> paper <a href="https://www.pnas.org/content/116/50/25106.long">"Geometrical reorganization of Dectin-1 and TLR2 on single phagosomes alters their synergistic immune signaling" </a> by Li et al. and the <em> Scientific Reports</em> paper<a href="https://www.nature.com/articles/s41598-021-92910-9"> "Spatial organization of FcγR and TLR2/1 on phagosome membranes differentially regulates their synergistic and inhibitory receptor crosstalk"</a> by Li et al. This video was captured using epi-fluorescence microscopy. <Br><Br>Related to video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6800">6800</a>.8/18/2023 12:40:34 PM8/18/2023 12:40:34 PMType    Name    Media Type    File Size    Modified Macrophage activation-H    High 20221 KB 1/21/2022 2:50 PM Dolan, Lauren (NIH/NIGMS) [C Here is the link to a STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15960https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{31BAA0E0-226C-4A0C-84A7-8C772C0B3749}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2336111Using a supercomputer to simulate the movement of atoms in a ribosome, researchers looked into the core of this protein-making nanomachine and took snapshots. The picture shows an amino acid (green) being delivered by transfer RNA (yellow) into a corridor (purple) in the ribosome. In the corridor, a series of chemical reactions will string together amino acids to make a protein. The research project, which tracked the movement of more than 2.6 million atoms, was the largest computer simulation of a biological structure to date. The results shed light on the manufacturing of proteins and could aid the search for new antibiotics, which typically work by disabling the ribosomes of bacteria. Featured in the November 15, 2005, issue of <a href=http://publications.nigms.nih.gov/biobeat/05-11-15/#1 target="_blank"><em>Biomedical Beat</em></a>.10/29/2020 2:33:42 PM10/29/2020 2:33:42 PMType    Name    Media Type    File Size    Modified NaturalNanomachine_L    Low 9 KB 6/3/2016 3:09 PM aamishral2 (NIH/NIGMS) [C The picture shows an amino acid STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx17050https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{0F17E42A-6033-4919-866E-9B591004F58D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2408124A crystal of bovine trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures.8/6/2020 7:35:04 PM8/6/2020 7:35:04 PMType    Name    Media Type    File Size    Modified f06S_bovine_trypsin1_S    Low 45 KB 9/7/2016 3:35 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14450https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1ECB22CB-2F0F-4EF3-A01B-E35F06A8D615}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1331167A cell in prometaphase during mitosis: The nuclear membrane breaks apart, and the spindle starts to interact with the chromosomes. Mitosis is responsible for growth and development, as well as for replacing injured or worn out cells throughout the body. For simplicity, mitosis is illustrated here with only six chromosomes. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.10/28/2020 8:13:05 PM10/28/2020 8:13:05 PMType    Name    Media Type    File Size    Modified ITC_Mito_prometa_Copy_M    Medium 34 KB 10/28/2020 4:12 PM McCulley, Jennifer (NIH/NIDCD) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx14750https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{7E13E187-C3F2-465B-99D5-E0F2C6FABFCA}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2508204Proteins are made of amino acids hooked end-to-end like beads on a necklace. To become active, proteins must twist and fold into their final, or "native," conformation." A protein's final shape enables it to accomplish its function. Featured in <a href=http://publications.nigms.nih.gov/structlife/ target="_blank"><i>The Structures of Life</i></a>.5/13/2024 6:21:12 PM5/13/2024 6:21:12 PMType    Name    Media Type    File Size    Modified Proteins_S    Low 53 KB 8/24/2016 5:20 PM Varkala, Venkat (NIH/NIGMS) [C A protein's final shape enables it STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx18750https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{975CBFB7-871F-4D5C-8451-06C1200425BA}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2355246Model of the enzyme Nicotinic acid phosphoribosyltransferase. This enzyme, from the archaebacterium, <i>Pyrococcus furiosus</i>, is expected to be structurally similar to a clinically important human protein called B-cell colony enhancing factor based on amino acid sequence similarities and structure prediction methods. The structure consists of identical protein subunits, each shown in a different color, arranged in a ring.10/29/2020 3:44:23 PM10/29/2020 3:44:23 PMType    Name    Media Type    File Size    Modified 2355_th_1367b1_Thumb    Thumbnail 100 KB 1/29/2021 4:23 PM McCulley, Jennifer (NIH/NIDCD) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx18550https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{32F0F10A-7087-466D-BEE4-36238144FEC6}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2349313Model of the catalytic portion of an enzyme, receptor-type tyrosine-protein phosphatase from humans. The enzyme consists of two identical protein subunits, shown in blue and green. The groups made up of purple and red balls represent phosphate groups, chemical groups that can influence enzyme activity. This phosphatase removes phosphate groups from the enzyme tyrosine kinase, counteracting its effects.10/29/2020 3:03:16 PM10/29/2020 3:03:16 PMType    Name    Media Type    File Size    Modified hi_2g59_L    Low 104 KB 6/3/2016 3:09 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15550https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{CC9AD2E9-0C9D-4FEC-BB74-721120B3F77D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2381317Model of an enzyme, dUTP pyrophosphatase, from <i>Mycobacterium tuberculosis</i>. Drugs targeted to this enzyme might inhibit the replication of the bacterium that causes most cases of tuberculosis.10/29/2020 4:45:35 PM10/29/2020 4:45:35 PMType    Name    Media Type    File Size    Modified 2381_hi_Rv2697c_S    Low 120 KB 3/29/2019 11:31 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12650https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{BA90BC5B-5136-4E5A-A949-B4104A70F686}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2495337The structure of the pore-forming protein VDAC-1 from humans. This molecule mediates the flow of products needed for metabolism--in particular the export of ATP--across the outer membrane of mitochondria, the power plants for eukaryotic cells. VDAC-1 is involved in metabolism and the self-destruction of cells--two biological processes central to health. Relates to a <a href=http://www.nigms.nih.gov/News/Results/20080904_announce.htm target="_blank">September 4, 2008 news release</a>.5/9/2022 1:30:48 PM5/9/2022 1:30:48 PMType    Name    Media Type    File Size    Modified 2495_VDAC-1d_T    Thumbnail 97 KB 4/19/2019 11:30 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx15150https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{63234710-58AE-43B6-B49A-FF06CF1D770B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2791366Ecteinascidin 743 (ET-743, brand name Yondelis), was discovered and isolated from a sea squirt, <i>Ecteinascidia turbinata</i>, by NIGMS grantee Kenneth Rinehart at the University of Illinois. It was synthesized by NIGMS grantees E.J. Corey and later by Samuel Danishefsky. It is being tested for the treatment of several types of cancer. Multiple versions of this structure are available as entries 2790-2797.2/22/2021 9:16:48 PM2/22/2021 9:16:48 PMType    Name    Media Type    File Size    Modified ET743_withhydrogens2_M    Medium 15 KB 6/3/2016 3:17 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx18550https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{7E9FE313-7ECC-410F-8624-D1F7D0E636A4}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2795370Ecteinascidin 743 (ET-743, brand name Yondelis), was discovered and isolated from a sea squirt, <i>Ecteinascidia turbinata</i>, by NIGMS grantee Kenneth Rinehart at the University of Illinois. It was synthesized by NIGMS grantees E.J. Corey and later by Samuel Danishefsky. It is being tested for the treatment of several types of cancer. Multiple versions of this structure are available as entries 2790-2797.2/22/2021 9:13:50 PM2/22/2021 9:13:50 PMType    Name    Media Type    File Size    Modified ET_743_2_L    Low 5 KB 6/3/2016 3:17 PM aamishral2 (NIH/NIGMS) [C It was synthesized by NIGMS grantees E.J. STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx16350https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{86C9B538-29A6-4393-97EA-0AFC5C537F94}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2796371Ecteinascidin 743 (ET-743, brand name Yondelis), was discovered and isolated from a sea squirt, <i>Ecteinascidia turbinata</i>, by NIGMS grantee Kenneth Rinehart at the University of Illinois. It was synthesized by NIGMS grantees E.J. Corey and later by Samuel Danishefsky. It is being tested for the treatment of several types of cancer. Multiple versions of this structure are available as entries 2790-2797.2/22/2021 9:13:21 PM2/22/2021 9:13:21 PMType    Name    Media Type    File Size    Modified ET_743_3_L    Low 6 KB 6/3/2016 3:18 PM aamishral2 (NIH/NIGMS) [C It was synthesized by NIGMS grantees E.J. STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx27950https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{E6169F09-5DE1-4290-8EC8-33659920398D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131