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3334933It has been said that gastrulation is the most important event in a person's life. This part of early embryonic development transforms a simple ball of cells and begins to define cell fate and the body axis. In a study published in Science magazine in March 2012, NIGMS grantee Bob Goldstein and his research group studied how contractions of actomyosin filaments in C. elegans and Drosophila embryos lead to dramatic rearrangements of cell and embryonic structure. This research is described in detail in the following <a href=http://www.sciencemag.org/content/335/6073/1232.abstract target="_blank"> article</a>: "Triggering a Cell Shape Change by Exploiting Preexisting Actomyosin Contractions." In these images, myosin (green) and plasma membrane (red) are highlighted at four timepoints in gastrulation in the roundworm C. elegans. The blue highlights in the top three frames show how cells are internalized, and the site of closure around the involuting cells is marked with an arrow in the last frame. See related image 3297.3/18/2022 4:17:40 PM3/18/2022 4:17:40 PMType    Name    Media Type    File Size    Modified 3334_Four_timepoints_in_gastrulation_S    Low 94 KB 3/29/2019 10:07 AM Constantinides, Stephen (NIH/NIGMS STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx8780https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1A2F782A-4872-4628-98F9-5A8C9E7D1034}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1329771A cell in metaphase during mitosis: The copied chromosomes align in the middle of the spindle. Mitosis is responsible for growth and development, as well as for replacing injured or worn out cells throughout the body. For simplicity, mitosis is illustrated here with only six chromosomes. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.10/28/2020 8:07:19 PM10/28/2020 8:07:19 PMType    Name    Media Type    File Size    Modified ITC_Mito_meta_Copy_M    Medium 40 KB 10/28/2020 4:06 PM McCulley, Jennifer (NIH/NIDCD) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx3795110https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{0AD97DB2-EE2C-4177-A434-A961D017F962}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1157641Image of <i>Streptococcus</i>, a type (genus) of spherical bacteria that can colonize the throat and back of the mouth. Stroptococci often occur in pairs or in chains, as shown here.3/13/2023 7:27:13 PM3/13/2023 7:27:13 PMType    Name    Media Type    File Size    Modified 1157_strept1color__S    Low 154 KB 3/29/2019 2:02 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx98100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{229D3635-54DB-44A1-B714-B5BF987E6975}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1166572<i>Leptospira</i>, shown here in green, is a type (genus) of elongated, spiral-shaped bacteria. Infection can cause Weil's disease, a kind of jaundice, in humans.3/13/2023 7:29:38 PM3/13/2023 7:29:38 PMType    Name    Media Type    File Size    Modified leptoc2color_M    Medium 194 KB 10/28/2020 11:46 AM McCulley, Jennifer (NIH/NIDCD) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx9790https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{7145A65C-BB14-4F68-9904-ABCBB1287DE5}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1275769The Golgi complex, also called the Golgi apparatus or, simply, the Golgi. This organelle receives newly made proteins and lipids from the ER, puts the finishing touches on them, addresses them, and sends them to their final destinations. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.10/28/2020 4:29:29 PM10/28/2020 4:29:29 PMType    Name    Media Type    File Size    Modified ITC_Golgi_inset_Copy_M    Medium 28 KB 10/28/2020 12:29 PM McCulley, Jennifer (NIH/NIDCD) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx3992450https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F1ACB139-25A3-4C54-8EE3-575084FC6DB6}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
57291189The HIV capsid is pear-shaped structure that is made of proteins the virus needs to mature and become infective. The capsid is inside the virus and delivers the virus' genetic information into a human cell. To better understand how the HIV capsid does this feat, scientists have used computer programs to simulate its assembly. This image shows a series of snapshots of the steps that grow the HIV capsid. A model of a complete capsid is shown on the far right of the image for comparison; the green, blue and red colors indicate different configurations of the capsid protein that make up the capsid “shell.” The bar in the left corner represents a length of 20 nanometers, which is less than a tenth the size of the smallest bacterium. Computer models like this also may be used to reconstruct the assembly of the capsids of other important viruses, such as Ebola or the Zika virus. <br><br> The studies reporting this research were published in <a href="http://www.nature.com/ncomms/2016/160513/ncomms11568/full/ncomms11568.html"><i>Nature Communications</i></a> and <a href="http://www.nature.com/nature/journal/v469/n7330/full/nature09640.html"><i>Nature</i></a>. <br><br> To learn more about how researchers used computer simulations to track the assembly of the HIV capsid, see <a href=" https://news.uchicago.edu/article/2016/06/14/simulations-describe-hivs-diabolical-delivery-device">this press release from the University of Chicago</a>.12/18/2020 4:10:47 PM12/18/2020 4:10:47 PMType    Name    Media Type    File Size    Modified HIV capsid synthesis 222px_TransparentBackground-1_S    Thumbnail 127 KB 3/20/2017 9:21 AM Machalek, Alisa STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx145110https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C1FD6483-5B69-49FD-9F08-5665166A3E1D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
7018648791A light organ (~0.5 mm across) of a juvenile Hawaiian bobtail squid, <em>Euprymna scolopes</em>. Movement of cilia on the surface of the organ aggregates bacterial symbionts (green) into two areas above sets of pores that lead to interior crypts. This image was taken using a confocal fluorescence microscope. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7016">7016</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7017">7017</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7019">7019</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=7020">7020</a>. 4/12/2024 1:09:51 PM4/12/2024 1:09:51 PMType    Name    Media Type    File Size    Modified Bacterial cells aggregating above the light organ of the Hawaiian bobtail squid We, the creators/owners of these STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx63160https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{02C15366-5DC0-4B82-99C0-9A10251E5B12}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68091233Two fruit fly (<em>Drosophila melanogaster</em>) egg cells, one on each side of the central black line. The colorful swirls show the circular movement of cytoplasm—called ooplasmic streaming—that occurs in late egg cell development in wild-type (right) and mutant (left) oocytes. This image was captured using confocal microscopy. <Br><Br> More information on the research that produced this image can be found in the <em>Journal of Cell Biology</em> paper <a href="https://rupress.org/jcb/article/217/10/3497/120275/Ooplasmic-flow-cooperates-with-transport-and">“Ooplasmic flow cooperates with transport and anchorage in <em>Drosophila</em> oocyte posterior determination”</a> by Lu et al. 1/21/2022 3:52:59 PM1/21/2022 3:52:59 PMType    Name    Media Type    File Size    Modified Drosophila ooplasmic streaming_T    Thumbnail 2 KB 2/11/2022 1:41 PM Crowley, Rachel (NIH/NIGMS) [E STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx114300https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{4D253170-106E-4EDF-AE42-322E3351BAE7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67771334A 3D model of the human endoplasmic reticulum membrane protein complex (EMC) that identifies its nine essential subunits. The EMC plays an important role in making membrane proteins, which are essential for all cellular processes. This is the first atomic-level depiction of the EMC. Its structure was obtained using single-particle cryo-electron microscopy.12/6/2021 8:02:51 PM12/6/2021 8:02:51 PMType    Name    Media Type    File Size    Modified EMC_NIGMSVideoGallery-Lg    High 4824 KB 12/7/2021 10:06 AM Dolan, Lauren (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx96200https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{6B9B0617-6BFC-4A30-8D67-74F630BF8AAD}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68041228<em>Staphylococcus aureus</em> bacteria (blue) on the porous coating of a femoral hip stem used in hip replacement surgery. The relatively rough surface of an implant is a favorable environment for bacteria to attach and grow. This can lead to the development of biofilms, which can cause infections. The researchers who took this image are working to understand where biofilms are likely to develop. This knowledge could support the prevention and treatment of infections. A scanning electron microscope was used to capture this image. <Br><Br>More information on the research that produced this image can be found in the <em>Antibiotics</em> paper<a href="https://www.mdpi.com/2079-6382/10/8/889"> "Free-floating aggregate and single-cell-initiated biofilms of <em>Staphylococcus aureus</em>" </a>by Gupta et al. <Br><Br>Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6803">6803</a> and video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6805">6805</a>.10/18/2023 2:56:58 PM10/18/2023 2:56:58 PMType    Name    Media Type    File Size    Modified S. aureus in the porous coating of a femoral stem_M    Medium 73 KB 1/20/2022 1:51 PM Crowley, Rachel (NIH STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx98180https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F8EB39E7-349E-48B6-A64F-0CDEEC68BEB6}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
35801158Industrious V. cholerae bacteria (yellow) tend to thrive in denser biofilms (left) while moochers (red) thrive in weaker biofilms (right). More information about the research behind this image can be found in a <a href="http://biobeat.nigms.nih.gov/2014/02/cool-image-denying-microbial-moochers/">Biomedical Beat Blog posting</a> from February 2014.10/5/2020 6:16:25 AM10/5/2020 6:16:25 AMType    Name    Media Type    File Size    Modified V_M._cholerae_biofilms_32    Medium 50 KB 6/3/2016 3:32 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx110170https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{21F937D8-3F14-4784-AC98-9E76BB4A34A8}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1102639This image shows two components of the cytoskeleton, microtubules (green) and actin filaments (red), in an endothelial cell derived from a cow lung. The cystoskeleton provides the cell with an inner framework and enables it to move and change shape.3/13/2023 7:34:03 PM3/13/2023 7:34:03 PMType    Name    Media Type    File Size    Modified prettycellb_M    Medium 26 KB 1/28/2021 8:06 AM McCulley, Jennifer (NIH/NIDCD) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx95210https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{FB4E12C9-A3D5-4790-ACFD-0086EA78117C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
58951006Details about the basic biology and chemistry of the ingredients that produce bioluminescence are allowing scientists to harness it as an imaging tool. Credit: Nathan Shaner, Scintillon Institute.<br></br> From Biomedical Beat article July 2017: <a href="https://biobeat.nigms.nih.gov/2017/07/chasing-fireflies-and-better-cellular-imaging-techniques/#more-4455">Chasing Fireflies—and Better Cellular Imaging Techniques</a>3/1/2021 7:16:46 PM3/1/2021 7:16:46 PMType    Name    Media Type    File Size    Modified bioluminescent microcentrifuge tubes_M    Medium 132 KB 7/21/2017 1:40 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx89180https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F551D249-3908-41B8-8C99-C5109BA71043}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
58741050Cryo-electron microscopy (cryo-EM) has the power to capture details of proteins and other small biological structures at the molecular level.&nbsp; This image shows proteins in the capsid, or outer cover, of bacteriophage P22, a virus that infects the Salmonella bacteria.&nbsp; Each color shows the structure and position of an individual protein in the capsid.&nbsp; Thousands of cryo-EM scans capture the structure and shape of all the individual proteins in the capsid and their position relative to other proteins. A computer model combines these scans into the 3-dimension image shown here.&nbsp; Related to image <a href="/Pages/DetailPage.aspx?imageID2=5875">5875</a>.12/18/2020 9:09:51 PM12/18/2020 9:09:51 PMType    Name    Media Type    File Size    Modified Bacteriophage22-cryoEM-T    Thumbnail 49 KB 6/23/2017 1:27 PM Machalek, Alisa (NIH/NIAMS) [E STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx95250https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B795949D-2B81-40F1-A108-BA57CBB23572}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3460549Recombinant proteins such as the prion protein shown here are often used to model how proteins misfold and sometimes polymerize in neurodegenerative disorders. This prion protein was expressed in E. coli, purified and fibrillized at pH 7. Image taken in 2004 for a research project by Roger Moore, Ph.D., at Rocky Mountain Laboratories that was published in 2007 in <i>Biochemistry</i>. This image was not used in the publication.8/31/2020 4:08:32 AM8/31/2020 4:08:32 AMType    Name    Media Type    File Size    Modified fibril_L    Low 57 KB 6/3/2016 3:29 PM aamishral2 (NIH/NIGMS) [C Recombinant proteins such as the prion STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx112120https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{D61A0D04-06B0-47B0-B82D-4FEDA379609F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2341466Model of the enzyme aminopeptidase N from the human pathogen <i>Neisseria meningitidis</i>, which can cause meningitis epidemics. The structure provides insight on the active site of this important molecule.10/29/2020 2:43:00 PM10/29/2020 2:43:00 PMType    Name    Media Type    File Size    Modified 2341_joachimiak1_S    Low 133 KB 3/29/2019 1:43 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx120180https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{C0E3C41D-D8EA-4EB0-92FA-CC970965AA6B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1178573This image of laboratory-grown cells was taken with the help of a scanning electron microscope, which yields detailed images of cell surfaces.3/13/2023 7:27:36 PM3/13/2023 7:27:36 PMType    Name    Media Type    File Size    Modified Cc6-1_M    Medium 136 KB 10/28/2020 10:56 AM McCulley, Jennifer (NIH/NIDCD) [C You can probably also use the STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx100220https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{35C19F9C-DCAE-43C4-A186-1D023A74CBF3}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69701348Multicellular yeast called snowflake yeast that researchers created through many generations of directed evolution from unicellular yeast. Cells are connected to one another by their cell walls, shown in blue. Stained cytoplasm (green) and membranes (magenta) show that the individual cells remain separate. This image was captured using spinning disk confocal microscopy. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6969">6969</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6971">6971</a>.11/15/2023 1:15:17 PM11/15/2023 1:15:17 PMType    Name    Media Type    File Size    Modified Snowflake Yeast 2_S    Low 56 KB 2/3/2023 5:02 PM Bigler, Abbey (NIH/NIGMS) [C Br><Br> I'm more than happy STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx156160https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{6131B071-A4E1-4EAB-9666-CA6A3FAF1CA7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68061230The two large, central, round shapes are ovaries from a typical fruit fly (<em>Drosophila melanogaster</em>). The small butterfly-like structures surrounding them are fruit fly ovaries where researchers suppressed the expression of a gene that controls microtubule polymerization and is necessary for normal development. This image was captured using a confocal laser scanning microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6807">6807</a>. 1/21/2022 3:55:03 PM1/21/2022 3:55:03 PMType    Name    Media Type    File Size    Modified Wild-type and mutant fruit fly ovaries_M    Medium 119 KB 2/11/2022 1:44 PM Dolan, Lauren (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx117140https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1CE96574-AF64-43B2-8987-EDADC4899FE7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68991301High-resolution time lapse of epithelial (skin) cell migration and wound healing. It shows an image taken every 13 seconds over the course of almost 14 minutes. The images were captured with quantitative orientation-independent differential interference contrast (DIC) microscope (left) and a conventional DIC microscope (right). <Br><Br>More information about the research that produced this video can be found in the <em>Journal of Microscopy</em> paper <a href="https://onlinelibrary.wiley.com/doi/10.1111/jmi.12682/">“An Orientation-Independent DIC Microscope Allows High Resolution Imaging of Epithelial Cell Migration and Wound Healing in a Cnidarian Model”</a> by Malamy and Shribak. 6/30/2022 4:45:48 PM6/30/2022 4:45:48 PMType    Name    Media Type    File Size    Modified circularlamellipodia    High 17708 KB 6/30/2022 3:03 PM Crowley, Rachel (NIH/NIGMS) [E STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx8270https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{497BC427-08F6-402E-B25B-3FF48F096460}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
37411181The photo shows a confocal microscopy image of perineuronal nets (PNNs), which are specialized extracellular matrix (ECM) structures in the brain. The PNN surrounds some nerve cells in brain regions including the cortex, hippocampus and thalamus. Researchers study the PNN to investigate their involvement stabilizing the extracellular environment and forming nets around nerve cells and synapses in the brain. Abnormalities in the PNNs have been linked to a variety of disorders, including epilepsy and schizophrenia, and they limit a process called neural plasticity in which new nerve connections are formed. To visualize the PNNs, researchers labeled them with Wisteria floribunda agglutinin (WFA)-fluorescein. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3742">image 3742</a>.12/17/2020 5:33:10 PM12/17/2020 5:33:10 PMType    Name    Media Type    File Size    Modified Cortex_neuronal_ECM_L    Low 43 KB 6/3/2016 3:40 PM aamishral2 (NIH/NIGMS) [C TEM 5: Soleus muscle ECM on STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx123240https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{49BF2F89-C3EB-46DB-A682-8EF8BF979760}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
65811067<i>C. elegans</i>, a tiny roundworm, with a ribosomal protein glowing red and muscle fibers glowing green. Researchers used these worms to study a molecular pathway that affects aging. The ribosomal protein is involved in protein translation and may play a role in dietary restriction-induced longevity. Image created using confocal microscopy. <br> View group of roundworms here <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6582">6582</a>. <br> View closeup of roundworms here <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6583">6583</a>. 3/19/2021 8:22:04 PM3/19/2021 8:22:04 PMType    Name    Media Type    File Size    Modified SingleWorm_M    Medium 28 KB 8/10/2020 8:26 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx74110https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{FD724E86-FCC2-4562-93CD-C85717D1F0FA}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3475550Georgia Tech associate professor Hang Lu holds a microfluidic chip that is part of a system that uses artificial intelligence and cutting-edge image processing to automatically examine large number of nematodes used for genetic research.8/31/2020 4:16:30 AM8/31/2020 4:16:30 AMType    Name    Media Type    File Size    Modified automated-worm-sorter146_L_thumbnail    Thumbnail 24 KB 6/3/2016 3:30 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx89130https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{4D59B2F6-D454-4F1E-8259-CD2F171FD480}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2596707In the top snapshots, the brain of a sleep-deprived fruit fly glows orange, marking high concentrations of a synaptic protein called Bruchpilot (BRP) involved in communication between neurons. The color particularly lights up brain areas associated with learning. By contrast, the bottom images from a well-rested fly show lower levels of the protein. These pictures illustrate the results of an April 2009 study showing that sleep reduces the protein's levels, suggesting that such "downscaling" resets the brain to normal levels of synaptic activity and makes it ready to learn after a restful night. Featured in the May 20, 2009, issue of <a href=http://publications.nigms.nih.gov/biobeat/09-05-20/index.html#1 target="_blank"><em>Biomedical Beat</em></a>.10/30/2020 7:21:43 PM10/30/2020 7:21:43 PMType    Name    Media Type    File Size    Modified sleep_fly1_L    Low 9 KB 6/3/2016 3:13 PM aamishral2 (NIH/NIGMS) [C These pictures illustrate the results of an April 2009 study showing that sleep reduces the protein's levels STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx76170https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{179D8D15-FAF6-4541-9811-87052DBCC0B8}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
37181025Bacterial biofilms are tightly knit communities of bacterial cells growing on, for example, solid surfaces, such as in water pipes or on teeth. Here, cells of the bacterium Bacillus subtilis have formed a biofilm in a laboratory culture. Researchers have discovered that the bacterial cells in a biofilm communicate with each other through electrical signals via specialized potassium ion channels to share resources, such as nutrients, with each other. This insight may help scientists to improve sanitation systems to prevent biofilms, which often resist common treatments, from forming and to develop better medicines to combat bacterial infections. See the Biomedical Beat blog post <a href="http://biobeat.nigms.nih.gov/2015/12/bacterial-biofilms-a-charged-environment /">Bacterial Biofilms: A Charged Environment</a> for more information.2/4/2020 6:02:20 PM2/4/2020 6:02:20 PMType    Name    Media Type    File Size    Modified Bacillus_subtilis_biofilm_S    Low 50 KB 8/26/2016 4:05 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx104110https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B78D9982-381F-4F28-93AC-ED860CAB3947}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
36751099Stained kidney tissue. The kidney is an essential organ responsible for disposing wastes from the body and for maintaining healthy ion levels in the blood. It also secretes two hormones, erythropoietin (EPO) and calcitriol (a derivative of vitamin D), into the blood. It works like a purifier by pulling break-down products of metabolism, such as urea and ammonium, from the blood stream for excretion in urine. Related to image <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=677">3725</a>. 2/4/2020 7:58:53 PM2/4/2020 7:58:53 PMType    Name    Media Type    File Size    Modified Slide18    High 423 KB 12/1/2020 1:07 PM Walter, Taylor (NIH/NIGMS) [C The kidney is an essential organ STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11770https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{7EE212D2-34BF-41C9-93D3-31DA36BC0BD5}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69661242Melanoma (skin cancer) cells undergoing programmed cell death, also called apoptosis. This process was triggered by raising the pH of the medium that the cells were growing in. Melanoma in people cannot be treated by raising pH because that would also kill healthy cells. This video was taken using a differential interference contrast (DIC) microscope.1/27/2023 9:56:19 PM1/27/2023 9:56:19 PMType    Name    Media Type    File Size    Modified Dying Melanoma Cells Thumbnail    Thumbnail 807 KB 1/27/2023 4:57 PM Bigler, Abbey (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12480https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{147295DE-FBF3-4ABD-8F77-D53B50BBA0FA}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1048632Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). This image is part of a series of images: <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1047">image 1047</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1049">image 1049</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1050">image 1050</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1051">image 1051</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1052">image 1052</a>.8/14/2020 5:58:28 PM8/14/2020 5:58:28 PMType    Name    Media Type    File Size    Modified triplet2_S    Low 8 KB 9/8/2016 2:20 PM Varkala, Venkat (NIH/NIGMS) [C Stereo triplet of a sea urchin embryo STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx9390https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1CDB20E5-FD75-4EAB-84A2-F83EFE6CEAF3}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
65921217Cell-like compartments that spontaneously emerged from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Image created using confocal microscopy. <br> <p>For more photos of cell-like compartments from frog eggs view: <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6584">6584</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6585">6585</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6586">6586</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6591">6591</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6593">6593</a>.</p> <p>For videos of cell-like compartments from frog eggs view:&nbsp;<a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6587">6587</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6588">6588</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6589">6589</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6590">6590</a>.</p>9/13/2020 3:38:40 PM9/13/2020 3:38:40 PMType    Name    Media Type    File Size    Modified img5_cheng_confocal_nuc_t40_M    Medium 66 KB 9/15/2020 10:07 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx91100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{10111D22-D87A-4A9F-82B8-5C98DB9E5D44}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2373468Crystal structure of oligoendopeptidase F, a protein slicing enzyme from <i>Bacillus stearothermophilus</i>, a bacterium that can cause food products to spoil. The crystal was formed using a microfluidic capillary, a device that enables scientists to independently control the parameters for protein crystal nucleation and growth. Featured as one of the July 2007 Protein Structure Initiative Structures of the Month.10/29/2020 4:30:39 PM10/29/2020 4:30:39 PMType    Name    Media Type    File Size    Modified 2373_hi_Oligoendopeptidase_S    Low 172 KB 3/29/2019 11:42 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx9880https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{0D97FDE5-F4E0-4172-A7C4-8FCFDBC60F26}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3443875These images show frog cells in interphase. The cells are Xenopus XL177 cells, which are derived from tadpole epithelial cells. The microtubules are green and the chromosomes are blue. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3442">image 3442</a>.8/22/2020 5:30:27 PM8/22/2020 5:30:27 PMType    Name    Media Type    File Size    Modified interphs    High 1903 KB 6/3/2016 3:29 PM aamishral2 (NIH/NIGMS) [C The microtubules are green and the STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx11090https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{5CE69473-3A28-4887-B8C1-AA71A16B23A9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2564895To splice a human gene into a plasmid, scientists take the plasmid out of an E. coli bacterium, cut the plasmid with a restriction enzyme, and splice in human DNA. The resulting hybrid plasmid can be inserted into another E. coli bacterium, where it multiplies along with the bacterium. There, it can produce large quantities of human protein. See image 2565 for a labeled version of this illustration. Featured in <a href=http://publications.nigms.nih.gov/thenewgenetics/ target="_blank"><i>The New Genetics</i></a>.10/30/2020 3:11:06 PM10/30/2020 3:11:06 PMType    Name    Media Type    File Size    Modified Recombinant_DNA_S    Low 54 KB 8/24/2016 2:51 PM Varkala, Venkat (NIH/NIGMS) [C To splice a human gene into a STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx10890https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B9D570D4-A13C-475A-83F9-F67DEAF4A0A7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69311267Various views of a mouse brain that was genetically modified so that subpopulations of its neurons glow. Researchers often study mice because they share many genes with people and can shed light on biological processes, development, and diseases in humans. <Br><Br> This video was captured using a light sheet microscope. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6929">6929</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6930">6930</a>. 3/28/2023 7:25:52 PM3/28/2023 7:25:52 PMType    Name    Media Type    File Size    Modified MouseBrainThumbnail    Thumbnail 251 KB 3/28/2023 1:42 PM Bigler, Abbey (NIH/NIGMS) [C A range of views of a STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx10380https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{E8BA1CD7-FBAD-470A-8536-1897FD575924}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3736984The extracellular matrix (ECM) is most prevalent in connective tissues but also is present between the stems (axons) of nerve cells, as shown here. Blue-colored nerve cell axons are surrounded by brown-colored, myelin-supplying Schwann cells, which act like insulation around an electrical wire to help speed the transmission of electric nerve impulses down the axon. The ECM is pale pink. The tiny brown spots within it are the collagen fibers that are part of the ECM.12/17/2020 4:38:32 PM12/17/2020 4:38:32 PMType    Name    Media Type    File Size    Modified myelinating_axons_L    Low 106 KB 6/3/2016 3:40 PM aamishral2 (NIH/NIGMS) [C TEM 5: Soleus muscle ECM on the muscle surface STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx120110https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{6FE83BF5-351D-471D-BB22-F0A000BC68F5}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3733981The image visualizes a part of the yeast molecular interaction network. The lines in the network represent connections among genes (shown as little dots) and different-colored networks indicate subnetworks, for instance, those in specific locations or pathways in the cell. Researchers use gene or protein expression data to build these networks; the network shown here was visualized with a program called <a href="http://cytoscape.org/">Cytoscape</a>. By following changes in the architectures of these networks in response to altered environmental conditions, scientists can home in on those genes that become central "hubs" (highly connected genes), for example, when a cell encounters stress. They can then further investigate the precise role of these genes to uncover how a cell's molecular machinery deals with stress or other factors. Related to images <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3730">3730</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3732">3732</a>.12/17/2020 4:34:35 PM12/17/2020 4:34:35 PMType    Name    Media Type    File Size    Modified cytoscape23_L    Low 609 KB 6/3/2016 3:40 PM aamishral2 (NIH/NIGMS) [C They can then further investigate the STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx111270https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{80B3929B-B41A-4C70-B3C1-19365D9D2E94}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
57511191Antibiotic resistance in microbes is a serious health concern. So researchers have turned their attention to how bacteria undo the action of some antibiotics. Here, scientists set out to find the conditions that help individual bacterial cells survive in the presence of the antibiotic rifampicin. The research team used Mycobacterium smegmatis, a more harmless relative of Mycobacterium tuberculosis, which infects the lung and other organs and causes serious disease. <Br><Br>In this image, genetically identical mycobacteria are growing in a miniature growth chamber called a microfluidic chamber. Using live imaging, the researchers found that individual mycobacteria will respond differently to the antibiotic, depending on the growth stage and other timing factors. The researchers used genetic tagging with green fluorescent protein to distinguish cells that can resist rifampicin and those that cannot. With this gene tag, cells tolerant of the antibiotic light up in green and those that are susceptible in violet, enabling the team to monitor the cells' responses in real time. <Br><Br> To learn more about how the researchers studied antibiotic resistance in Mycobacterium, see <a href="http://now.tufts.edu/news-releases/individual-mycobacteria-respond-differently-antibiotics-based-growth-and-timing">this news release from Tufts University</a>. Related to <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=2990">video 5752</a>.12/18/2020 4:27:18 PM12/18/2020 4:27:18 PMType    Name    Media Type    File Size    Modified 5751_SSBGFP_RIF2_40ul_100313_17_S    Low 107 KB 3/28/2019 3:25 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx112100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{9AAEDFAF-443D-4710-BA88-4BEBD4E1B128}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
65821068Three <i>C. elegans</i>, tiny roundworms, with a ribosomal protein glowing red and muscle fibers glowing green. Researchers used these worms to study a molecular pathway that affects aging. The ribosomal protein is involved in protein translation and may play a role in dietary restriction-induced longevity. Image created using confocal microscopy. <br>View single roundworm here <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6581">6581</a>. <br> View closeup of roundworms here <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6583">6583</a>.3/19/2021 8:20:52 PM3/19/2021 8:20:52 PMType    Name    Media Type    File Size    Modified ThreeWorms_M    Medium 49 KB 8/10/2020 8:39 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx8180https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{AFFC83D5-1CA9-4F1F-AB09-4C4B88D3E492}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2747844This video shows an instance of abnormal mitosis where chromosomes are late to align. The video demonstrates the spindle checkpoint in action: just one unaligned chromosome can delay anaphase and the completion of mitosis. The cells shown are S3 tissue cultured cells from <i>Xenopus laevis</i>, African clawed frog.8/18/2020 7:49:01 PM8/18/2020 7:49:01 PMType    Name    Media Type    File Size    Modified 2747_Cell_division_with_late_aligning_chromosomes_S    Low 62 KB 3/29/2019 10:58 AM Constantinides, Stephen STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx9390https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{FD7DD0B5-4B32-4B66-BEE4-BB5168CB81FD}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2423675Network diagram showing a map of protein-protein interactions in a yeast (<i>Saccharomyces cerevisiae</i>) cell. This cluster includes 78 percent of the proteins in the yeast proteome. The color of a node represents the phenotypic effect of removing the corresponding protein (red, lethal; green, nonlethal; orange, slow growth; yellow, unknown).8/17/2020 9:20:50 PM8/17/2020 9:20:50 PMType    Name    Media Type    File Size    Modified protein_map182    High 229 KB 6/3/2016 3:10 PM aamishral2 (NIH/NIGMS) [C I'm more than happy to allow to use STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx84100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F93DC033-4F3F-4368-8211-AD3F2769B90F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3307732A study published in March 2012 used cryo-electron microscopy to determine the structure of the DNA replication origin recognition complex (ORC), a semi-circular, protein complex (yellow) that recognizes and binds DNA to start the replication process. The ORC appears to wrap around and bend approximately 70 base pairs of double stranded DNA (red and blue). Also shown is the protein Cdc6 (green), which is also involved in the initiation of DNA replication. The video shows the structure from different angles. From a Brookhaven National Laboratory <a href=http://www.bnl.gov/bnlweb/pubaf/pr/PR_display.asp?prID=1391&template=Today target="_blank">news release</a>, "Study Reveals How Protein Machinery Binds and Wraps DNA to Start Replication." See related image <a href=http://images.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3597><i>3597</i></a>.12/22/2020 11:01:10 PM12/22/2020 11:01:10 PMType    Name    Media Type    File Size    Modified ORC-pic_T    Thumbnail 222 KB 6/21/2016 11:24 AM aavarkalavr (NIH/NIGMS) [C A study published in March 2012 STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx10990https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{4E2A15E1-0A1E-4F7D-9AE7-49FFE5103E20}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69621238A <em>Trigonium</em> diatom imaged by a quantitative orientation-independent differential interference contrast (OI-DIC) microscope. Diatoms are single-celled photosynthetic algae with mineralized cell walls that contain silica and provide protection and support. These organisms form an important part of the plankton at the base of the marine and freshwater food chains. The width of this image is 90 μm. <Br><Br> More information about the microscopy that produced this image can be found in the <em>Journal of Microscopy</em> paper <a href="https://onlinelibrary.wiley.com/doi/10.1111/jmi.12682/">“An Orientation-Independent DIC Microscope Allows High Resolution Imaging of Epithelial Cell Migration and Wound Healing in a Cnidarian Model”</a> by Malamy and Shribak. 1/27/2023 9:46:30 PM1/27/2023 9:46:30 PMType    Name    Media Type    File Size    Modified Trigonium_M    Medium 692 KB 1/27/2023 4:29 PM Bigler, Abbey (NIH/NIGMS) [C The image width is 90 μm STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx155100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{F78335F9-FB37-4883-9939-AEB00AE242F9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69291265A mouse brain that was genetically modified so that subpopulations of its neurons glow. Researchers often study mice because they share many genes with people and can shed light on biological processes, development, and diseases in humans. <Br><Br> This image was captured using a light sheet microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6930">6930</a> and video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6931">6931</a>. 3/28/2023 7:24:12 PM3/28/2023 7:24:12 PMType    Name    Media Type    File Size    Modified Green Mouse Brain_M    Medium 466 KB 3/28/2023 1:26 PM Bigler, Abbey (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx131100https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{69FC294A-0B60-42B9-8ECF-C9318895AAF5}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2398607A crystal of RNase A protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures.8/6/2020 3:59:25 PM8/6/2020 3:59:25 PMType    Name    Media Type    File Size    Modified f02K_RNase_A1_S    Low 38 KB 9/7/2016 3:20 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx100120https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{E0AEE516-3DB0-4030-B7D3-D192F02C6479}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2322591What looks like a Native American dream catcher is really a network of social interactions within a community. The red dots along the inner and outer circles represent people, while the different colored lines represent direct contact between them. All connections originate from four individuals near the center of the graph. Modeling social networks can help researchers understand how diseases spread. Featured in the July 19, 2005, issue of <a href=http://publications.nigms.nih.gov/biobeat/05-07-19/#1 target="_blank"><em>Biomedical Beat</em></a>.12/20/2021 8:56:59 PM12/20/2021 8:56:59 PMType    Name    Media Type    File Size    Modified modeling_disease_spread2_M    Medium 23 KB 6/3/2016 3:08 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx183250https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{1F12E63B-4E70-4853-AD74-33C85990768D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
36771100Cross section of human skeletal muscle. Image taken with a confocal fluorescent light microscope.12/1/2020 6:09:36 PM12/1/2020 6:09:36 PMType    Name    Media Type    File Size    Modified Slide35    High 284 KB 12/1/2020 1:09 PM Walter, Taylor (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx8970https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{A561A04A-186A-449A-88E2-FC32FB8148C9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
57561116Pigment cells are cells that give skin its color. In fishes and amphibians, like frogs and salamanders, pigment cells are responsible for the characteristic skin patterns that help these organisms to blend into their surroundings or attract mates. The pigment cells are derived from neural crest cells, which are cells originating from the neural tube in the early embryo. This image shows pigment cells from pearl danio, a relative of the popular laboratory animal zebrafish. Investigating pigment cell formation and migration in animals helps answer important fundamental questions about the factors that control pigmentation in the skin of animals, including humans. Related to images <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=2996">5754</a>, <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3000">5755</a>, <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3011">5757</a> and <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3016">5758.12/18/2020 4:53:41 PM12/18/2020 4:53:41 PMType    Name    Media Type    File Size    Modified parichy-02_M    Medium 67 KB 7/13/2016 5:57 PM Varkala, Venkat (NIH/NIGMS) [C I’d be happy to make some high STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx8470https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{09E26DA0-9005-49C0-A268-3998B5DA6C97}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
35731155Scientists revealed a detailed image of the genetic defect that causes myotonic dystrophy type 2 and used that information to design drug candidates to counteract the disease. More information about the research behind this image can be found in a <a href="http://biobeat.nigms.nih.gov/2014/01/targeting-toxic-rna-molecules-in-muscular-dystrophy/" target=_blank>Biomedical Beat</a> Blog posting from January 2014.10/5/2020 5:50:20 AM10/5/2020 5:50:20 AMType    Name    Media Type    File Size    Modified 3573_Disney_acsimage_thumbnail    Thumbnail 57 KB 3/12/2019 12:25 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx10870https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{23107167-597E-46A9-BAF0-3B572CEF8896}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
35971089A study published in March 2012 used cryo-electron microscopy to determine the structure of the DNA replication origin recognition complex (ORC), a semi-circular, protein complex (yellow) that recognizes and binds DNA to start the replication process. The ORC appears to wrap around and bend approximately 70 base pairs of double stranded DNA (red and blue). Also shown is the protein Cdc6 (green), which is also involved in the initiation of DNA replication. Related to video <a href=http://images.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3307><i>3307</i></a> that shows the structure from different angles. From a Brookhaven National Laboratory <a href=http://www.bnl.gov/bnlweb/pubaf/pr/PR_display.asp?prID=1391&template=Today target="_blank">news release</a>, "Study Reveals How Protein Machinery Binds and Wraps DNA to Start Replication." 10/19/2020 6:35:19 AM10/19/2020 6:35:19 AMType    Name    Media Type    File Size    Modified 3597_DNA_replication_origin_recognition_complex__ORC_S    Low 132 KB 3/28/2019 4:08 PM Constantinides STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx12480https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B3B34891-56E7-4C4C-AC4A-53B710F155A1}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
57521192Antibiotic resistance in microbes is a serious health concern. So researchers have turned their attention to how bacteria undo the action of some antibiotics. Here, scientists set out to find the conditions that help individual bacterial cells survive in the presence of the antibiotic rifampicin. The research team used Mycobacterium smegmatis, a more harmless relative of Mycobacterium tuberculosis, which infects the lung and other organs to cause serious disease.<Br><Br> In this video, genetically identical mycobacteria are growing in a miniature growth chamber called a microfluidic chamber. Using live imaging, the researchers found that individual mycobacteria will respond differently to the antibiotic, depending on the growth stage and other timing factors. The researchers used genetic tagging with green fluorescent protein to distinguish cells that can resist rifampicin and those that cannot. With this gene tag, cells tolerant of the antibiotic light up in green and those that are susceptible in violet, enabling the team to monitor the cells' responses in real time. <Br><Br> To learn more about how the researchers studied antibiotic resistance in Mycobacterium, see <a href="http://now.tufts.edu/news-releases/individual-mycobacteria-respond-differently-antibiotics-based-growth-and-timing">this news release from Tufts University</a>. Related to <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=2986">image 5751</a>. 12/18/2020 4:30:09 PM12/18/2020 4:30:09 PMType    Name    Media Type    File Size    Modified 5752_SSBGFP_RIF2_40ul_100313_22_R3D_final-1_S    Low 60 KB 3/28/2019 3:24 PM Constantinides, Stephen (NIH STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx10380https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{B047CD99-8652-40DA-9486-2419FB70E5F6}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67481244A replica of a human retina grown from stem cells. It shows rod photoreceptors (nerve cells responsible for dark vision) in green and red/green cones (nerve cells responsible for red and green color vision) in red. The cell nuclei are stained blue. This image was captured using a confocal microscope.3/18/2021 2:46:22 PM3/18/2021 2:46:22 PMType    Name    Media Type    File Size    Modified PRs retinal organoid og_large_M    Medium 277 KB 3/18/2021 10:39 AM Walter, Taylor (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx9680https://images.nigms.nih.govhtmlTruehttps://imagesadmin.nigms.nih.gov{7745E02E-83F3-4FCE-A6AA-6A8FD7660CB1}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131