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242323385Network diagram showing a map of protein-protein interactions in a yeast (<i>Saccharomyces cerevisiae</i>) cell. This cluster includes 78 percent of the proteins in the yeast proteome. The color of a node represents the phenotypic effect of removing the corresponding protein (red, lethal; green, nonlethal; orange, slow growth; yellow, unknown).8/17/2020 9:20:50 PM8/17/2020 9:20:50 PMType    Name    Media Type    File Size    Modified protein_map182    High 229 KB 6/3/2016 3:10 PM aamishral2 (NIH/NIGMS) [C I'm more than happy to allow to use STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{F93DC033-4F3F-4368-8211-AD3F2769B90F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
242523386Influenza A infects a host cell when hemagglutinin grips onto glycans on its surface. Neuraminidase, an enzyme that chews sugars, helps newly made virus particles detach so they can infect other cells. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2505">image 2505</a>. Featured in the March 2006, issue of <a href=http://www.nigms.nih.gov/Publications/Findings.htm target="_blank"><I>Findings</i></a> in "Viral Voyages."2/5/2020 4:07:20 PM2/5/2020 4:07:20 PMType    Name    Media Type    File Size    Modified Influenza_Virus_S    Low 76 KB 8/24/2016 3:35 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{C6EF752E-ED4B-44D9-83F0-1612EBC81110}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
242623387The structure of a gene-regulating zinc finger protein bound to DNA.8/17/2020 9:31:43 PM8/17/2020 9:31:43 PMType    Name    Media Type    File Size    Modified DesignedZF    High 595 KB 6/3/2016 3:10 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{05B06D12-30DC-46F0-97A0-41AAFF3B328B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
242823388Actin (purple), microtubules (yellow), and nuclei (green) are labeled in these cells by immunofluorescence. This image won first place in the Nikon 2003 Small World photo competition.8/17/2020 9:33:48 PM8/17/2020 9:33:48 PMType    Name    Media Type    File Size    Modified Wittmann1_S    Low 88 KB 9/7/2016 3:02 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{7B30D101-F2A2-4554-87B0-71C2FC1D3774}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
242923389The cytoskeleton (green) and DNA (purple) are highlighed in these cells by immunofluorescence.8/17/2020 9:36:09 PM8/17/2020 9:36:09 PMType    Name    Media Type    File Size    Modified Wittmann2_M    Medium 284 KB 9/7/2016 3:05 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{3A889D00-8849-4CED-A940-48E94DD31348}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
243023390Image showing rhabdomeres (red), the light-sensitive structures in the fruit fly retina, and rhodopsin-4 (blue), a light-sensing molecule.8/18/2020 9:04:58 PM8/18/2020 9:04:58 PMType    Name    Media Type    File Size    Modified Fruit_fly_retina_1    High 106 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{CF24BF64-087F-46FC-883A-AF40149A41AE}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
243123391Cells in an early-stage fruit fly embryo, showing the DIAP1 protein (pink), an inhibitor of apoptosis.8/18/2020 9:15:52 PM8/18/2020 9:15:52 PMType    Name    Media Type    File Size    Modified Fruit_fly_embryo__DIAP1_    High 2732 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{8EE49691-A593-4D52-A276-0812121F89C5}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
243223392Cell showing overproduction of the ARTS protein (red). ARTS triggers apoptosis, as shown by the activation of caspase-3 (green) a key tool in the cell's destruction. The nucleus is shown in blue. Image is featured in October 2015 Biomedical Beat blog post <a href="http://biobeat.nigms.nih.gov/2015/10/cool-images-a-halloween-inspired-cell-collection/" target="_">Cool Images: A Halloween-Inspired Cell Collection</a>.8/18/2020 9:19:05 PM8/18/2020 9:19:05 PMType    Name    Media Type    File Size    Modified ARTS_triggers_apoptosis    High 81 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{5E4EB106-B5AB-408D-802C-F9AD60D9DC04}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
341223393Active Site of E. coli response regulator PhoB12/23/2020 8:56:09 PM12/23/2020 8:56:09 PMType    Name    Media Type    File Size    Modified PhoB_hires_copy_M    Medium 189 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS) [C I have an image at 8,000 x STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{6EE05E04-C77C-409C-9469-654526ACE090}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
341323394X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (2012). Series of seven images. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3414">image 3414</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3415">image 3415</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3416">image 3416</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3417">image 3417</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3418">image 3418</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3419">image 3419</a>.12/23/2020 11:02:46 PM12/23/2020 11:02:46 PMType    Name    Media Type    File Size    Modified macrocycle4b_copy_M    Medium 66 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS) [C WE are happy to give you STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{082D0675-FCFD-4E1E-9ECB-FE9441E456BA}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
341423395X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (2012). Series of seven images. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3413">image 3413</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3415">image 3415</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3416">image 3416</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3417">image 3417</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3418">image 3418</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3419">image 3419</a>.12/23/2020 11:04:41 PM12/23/2020 11:04:41 PMType    Name    Media Type    File Size    Modified binding_site_of_Src_kinase_for_macrocycle_inhibitors    High 375 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{FC3B2E45-4B75-43F5-AB53-B66E4E536897}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
341523396X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (2012). Series of seven images. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3413">image 3413</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3414">image 3414</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3416">image 3416</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3417">image 3417</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3418">image 3418</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3419">image 3419</a>.12/23/2020 11:07:01 PM12/23/2020 11:07:01 PMType    Name    Media Type    File Size    Modified Src_kinase_in_complex_with_macrocycle4b_copy_M    Medium 95 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{BAF7CEA2-E05B-4260-AA04-C2DA7BA3228A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
341623397X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (2012). Series of seven images. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3413">image 3413</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3414">image 3414</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3415">image 3415</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3417">image 3417</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3418">image 3418</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3419">image 3419</a>.12/23/2020 11:08:36 PM12/23/2020 11:08:36 PMType    Name    Media Type    File Size    Modified image_2    High 523 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS) [C X-ray co-crystal structure of Src kinase STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{4AE56C0B-1545-4D0A-997E-59755F61D8EE}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
341723398X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (2012). Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3413">image 3413</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3414">image 3414</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3415">image 3415</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3416">image 3416</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3418">image 3418</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3419">image 3419</a>.12/23/2020 11:12:30 PM12/23/2020 11:12:30 PMType    Name    Media Type    File Size    Modified image3_M    Medium 106 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS) [C nigms.nih.gov/index.cfm?event=viewDetail STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{216ADE51-44AC-4706-8E52-63EB7D76C69C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
341823399X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (2012). <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3413">image 3413</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3414">image 3414</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3415">image 3415</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3416">image 3416</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3417">image 3417</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3419">image 3419</a>.12/23/2020 11:12:00 PM12/23/2020 11:12:00 PMType    Name    Media Type    File Size    Modified macrocycle4b_stick_representation    High 349 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{151298FF-60F5-42C1-8AA6-94F7FD3186DD}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
341923400X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (2012). Part of an image series: <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3413">image 3413</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3414">image 3414</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3415">image 3415</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3416">image 3416</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3417">image 3417</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3418">image 3418</a>.12/23/2020 11:13:50 PM12/23/2020 11:13:50 PMType    Name    Media Type    File Size    Modified macrocylcle4b_balls_stick_3color_M    Medium 89 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{BACDE248-1F0A-40F9-80C2-B23609B91078}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
653523401Kupffer cells appear in the liver during the early stages of mammalian development and stay put throughout life to protect liver cells, clean up old red blood cells, and regulate iron levels. Source article <a href="https://directorsblog.nih.gov/2019/12/12/replenishing-the-livers-immune-protections/">Replenishing the Liver’s Immune Protections</a>. Posted on December 12th, 2019 by Dr. Francis Collins.12/21/2020 7:51:16 PM12/21/2020 7:51:16 PMType    Name    Media Type    File Size    Modified Kupffer_cell_in_liver-1_NCMIR_thumbnail    Thumbnail 118 KB 12/18/2019 1:38 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{3A1E4A5A-E2A1-4267-A145-D69C64F52A7A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
653623402Sepsis is the body’s overactive and extreme response to an infection. More than 1.7 million people get sepsis each year in the United States. Without prompt treatment, sepsis can lead to tissue damage, organ failure, and death. Many NIGMS-supported researchers are working to improve sepsis diagnosis and treatment. Learn more with our <a href="https://www.nigms.nih.gov/education/Pages/factsheet_sepsis.aspx"> sepsis fact sheet</a>. <br><br> See <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6551">6551</a> for the Spanish version of this infographic. 1/26/2022 3:33:16 PM1/26/2022 3:33:16 PMType    Name    Media Type    File Size    Modified Sepsis-508_m    Medium 339 KB 9/23/2020 4:12 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{C1831FC8-0317-491C-987F-6CC9D97A7609}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
653823403Learn how research organisms, such as fruit flies and mice, can help us understand and treat human diseases. Discover more resources from NIGMS’ <a href="https://www.nigms.nih.gov/education/pathways/Pages/Home.aspx">Pathways</a> collaboration with Scholastic. View the <a href="https://www.youtube.com/watch?v=ibSbNUhCNIo&list=PL9fzcZ7JxMmZry8oLhKq9Iaf4EPVinIXf&index=4">video<img src="https://www.nigms.nih.gov/PublishingImages/exitdisclaimer.gif" alt="Link to external web site" style="border-width: 0px;"/></a> on YouTube for closed captioning.12/4/2020 3:05:09 PM12/4/2020 3:05:09 PMType    Name    Media Type    File Size    Modified Pathways- The Fascinating Cells of Research Organisms    High 15996 KB 2/28/2020 4:44 PM Varkala, Venkat STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{FCD067CD-05CC-4D15-99F4-8D4CE81C3405}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
653923404Learn about basic science, sometimes called “pure” or “fundamental” science, and how it contributes to the development of medical treatments. Discover more resources from NIGMS’ <a href="https://www.nigms.nih.gov/education/pathways/Pages/Home.aspx">Pathways</a> collaboration with Scholastic. View the <a href="https://www.youtube.com/watch?v=9Fg2uXLxtII&list=PL9fzcZ7JxMmZry8oLhKq9Iaf4EPVinIXf&index=3">video<img src="https://www.nigms.nih.gov/PublishingImages/exitdisclaimer.gif" alt="Link to external web site" style="border-width: 0px;"/></a> on YouTube for closed captioning.12/4/2020 3:06:20 PM12/4/2020 3:06:20 PMType    Name    Media Type    File Size    Modified Pathways- What is Basic Science_    High 17837 KB 2/28/2020 4:44 PM Mills, Matt (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{8BFE73F4-37AE-4CCA-9C55-CC53A34536DF}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
654023405Learn how curiosity about the world and our cells is key to scientific discoveries. Discover more resources from NIGMS’ <a href="https://www.nigms.nih.gov/education/pathways/Pages/Home.aspx">Pathways</a> collaboration with Scholastic. View the <a href="https://www.youtube.com/watch?v=GlFeLIJyPE8&list=PL9fzcZ7JxMmZry8oLhKq9Iaf4EPVinIXf&index=1">video<img src="https://www.nigms.nih.gov/PublishingImages/exitdisclaimer.gif" alt="Link to external web site" style="border-width: 0px;"/></a> on YouTube for closed captioning.12/4/2020 3:01:58 PM12/4/2020 3:01:58 PMType    Name    Media Type    File Size    Modified Pathways- What is It_ _ Why Scientists Study Cells    High 19877 KB 2/28/2020 4:43 PM Mills, Matt (NIH/NIGMS STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{A9D268FF-0480-4646-A964-0A30288099B9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
654123406Learn about some of the different jobs in a scientific laboratory and how researchers work as a team to make discoveries. Discover more resources from NIGMS’ <a href="https://www.nigms.nih.gov/education/pathways/Pages/Home.aspx">Pathways</a> collaboration with Scholastic. View the <a href="https://www.youtube.com/watch?v=6Zwx-73hwug&list=PL9fzcZ7JxMmZry8oLhKq9Iaf4EPVinIXf&index=2">video<img src="https://www.nigms.nih.gov/PublishingImages/exitdisclaimer.gif" alt="Link to external web site" style="border-width: 0px;"/></a> on YouTube for closed captioning.12/21/2020 7:57:45 PM12/21/2020 7:57:45 PMType    Name    Media Type    File Size    Modified Pathways- What's the Connection_ _ Different Jobs in a Science Lab    High 15158 KB 2/28/2020 4:39 PM Mills STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{2E3D6466-EF3A-4FBB-BC45-20BA0A6881D5}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
654723407A cell nucleus (blue) surrounded by lipid droplets (yellow). Exogenously expressed, S-tagged UBXD8 (green) recruits endogenous p97/VCP (red) to the surface of lipid droplets in oleate-treated HeLa cells. Nucleus stained with DAPI.7/27/2022 2:47:00 PM7/27/2022 2:47:00 PMType    Name    Media Type    File Size    Modified UBXD8-VCP delta3_Thumb    Thumbnail 123 KB 3/19/2020 12:27 AM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{0B68426A-CD04-4261-A283-3B38152FDF13}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
654823408Cilia (cilium in singular) are complex molecular machines found on many of our cells. One component of cilia is the doublet microtubule, a major part of cilia’s skeletons that give them support and shape. This animated image is a partial model of a doublet microtubule’s structure based on cryo-electron microscopy images. Video can be found here <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6549"> 6549. </a>12/22/2020 3:28:03 PM12/22/2020 3:28:03 PMType    Name    Media Type    File Size    Modified 18046_Axoneme_Still_Watermark_Thumb    Thumbnail 39 KB 3/19/2020 3:12 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{B48B9B01-3F87-4F01-8650-EE6F89E59501}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
244223409<i>Hydra magnipapillata</i> is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis.8/19/2020 2:52:08 PM8/19/2020 2:52:08 PMType    Name    Media Type    File Size    Modified D20_2932-2    High 588 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C I sent the images for that purpose STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{AFEC3CCF-4521-4FBE-B588-7EF06ED5D31B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
244323410This map paints a colorful portrait of human genetic variation around the world. Researchers analyzed the DNA of 485 people and tinted the genetic types in different colors to produce one of the most detailed maps of its kind ever made. The map shows that genetic variation decreases with increasing distance from Africa, which supports the idea that humans originated in Africa, spread to the Middle East, then to Asia and Europe, and finally to the Americas. The data also offers a rich resource that scientists could use to pinpoint the genetic basis of diseases prevalent in diverse populations. Featured in the March 19, 2008, issue of <a href=http://publications.nigms.nih.gov/biobeat/08-03-19/index.html target="_blank"><em>Biomedical Beat</em></a>.8/19/2020 2:47:57 PM8/19/2020 2:47:57 PMType    Name    Media Type    File Size    Modified Researchers analyzed the DNA of 485 people and tinted the genetic types in different colors to produce one of the most detailed maps of its STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{65A6E7D0-EABC-412A-9154-D7109715B67E}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
245023411Blood clots stop bleeding, but they also can cause heart attacks and strokes. A team led by computational biophysicist Klaus Schulten of the University of Illinois at Urbana-Champaign has revealed how a blood protein can give clots their lifesaving and life-threatening abilities. The researchers combined experimental and computational methods to animate fibrinogen, a protein that forms the elastic fibers that enable clots to withstand the force of blood pressure. This simulation shows that the protein, through a series of events, stretches up to three times its length. Adjusting this elasticity could improve how we manage healthful and harmful clots. NIH's National Center for Research Resources also supported this work. Featured in the March 19, 2008, issue of <a href=http://publications.nigms.nih.gov/biobeat/08-03-19/index.html#1 target="_blank"><em>Biomedical Beat</em></a>. Note: You may need to download the free <a href="http://www.apple.com/quicktime/download/" target="_blank">Quicktime</a> player to view the movie.8/20/2020 4:59:49 PM8/20/2020 4:59:49 PMType    Name    Media Type    File Size    Modified 2450_Blood_clots_show_their_S    Low 33 KB 3/29/2019 11:28 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{721496EB-5A9D-4168-8B4F-7D9A971088EA}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
245123412Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. In order to fulfill these diverse roles, the timing and location of Cdc42 activation must be tightly controlled. Klaus Hahn and his research group use special dyes designed to report protein conformational changes and interactions, here in living neutrophil cells. Warmer colors in this image indicate higher levels of activation. Cdc42 looks to be activated at cell protrusions.5/9/2022 1:33:37 PM5/9/2022 1:33:37 PMType    Name    Media Type    File Size    Modified filo_cell_1    High 231 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C Warmer colors in this image indicate STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{6AC8DB1A-B5E1-462E-9265-2D1A58E2C6F4}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
245223413Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. In order to fulfill these diverse roles, the timing and location of Cdc42 activation must be tightly controlled. Klaus Hahn and his research group use special dyes designed to report protein conformational changes and interactions, here in living neutrophil cells. Warmer colors in this image indicate higher levels of activation. Cdc42 looks to be activated at cell protrusions.5/9/2022 1:34:32 PM5/9/2022 1:34:32 PMType    Name    Media Type    File Size    Modified whole_cell_2    High 611 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C Warmer colors in this image indicate STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{9DE4D092-49B1-4B56-947A-F66CFCF79C41}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
245323414Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. In order to fulfill these diverse roles, the timing and location of Cdc42 activation must be tightly controlled. Klaus Hahn and his research group use special dyes designed to report protein conformational changes and interactions, here in living neutrophil cells. Warmer colors in this image indicate higher levels of activation. Cdc42 looks to be activated at cell protrusions.5/9/2022 1:35:12 PM5/9/2022 1:35:12 PMType    Name    Media Type    File Size    Modified whole_cell_3_L    Low 32 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C Warmer colors in this image indicate STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{DC3FE02E-7EBA-4EBC-A440-03C6233481F9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
245423415Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. In order to fulfill these diverse roles, the timing and location of Cdc42 activation must be tightly controlled. Klaus Hahn and his research group use special dyes designed to report protein conformational changes and interactions, here in living neutrophil cells. Warmer colors in this image indicate higher levels of activation. Cdc42 looks to be activated at cell protrusions.5/9/2022 1:35:41 PM5/9/2022 1:35:41 PMType    Name    Media Type    File Size    Modified whole_cell_4    High 429 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C Warmer colors in this image indicate STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{4C51C6CF-03A7-440E-9698-B6D5811B7A57}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
245523416A team of chemists and physicists used nanotechnology and DNA's ability to self-assemble with matching RNA to create a new kind of chip for measuring gene activity. When RNA of a gene of interest binds to a DNA tile (gold squares), it creates a raised surface (white areas) that can be detected by a powerful microscope. This nanochip approach offers manufacturing and usage advantages over existing gene chips and is a key step toward detecting gene activity in a single cell. Featured in the February 20, 2008, issue of <a href=http://publications.nigms.nih.gov/biobeat/08-02-20/index.html#1 target="_blank"><em>Biomedical Beat</em></a>.8/20/2020 5:51:20 PM8/20/2020 5:51:20 PMType    Name    Media Type    File Size    Modified 2455_Gold_gene_S    Low 127 KB 3/29/2019 11:27 AM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{1D011269-3AA9-44C4-8D58-702C27B5F5B6}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
342923417The molecule on the left is an electrostatic potential map of the van der Waals surface of the transition state for human purine nucleoside phosphorylase. The colors indicate the electron density at any position of the molecule. Red indicates electron-rich regions with negative charge and blue indicates electron-poor regions with positive charge. The molecule on the right is called DADMe-ImmH. It is a chemically stable analogue of the transition state on the left. It binds to the enzyme millions of times tighter than the substrate. This inhibitor is in human clinical trials for treating patients with gout. This image appears in Figure 4, Schramm, V.L. (2011) Annu. Rev. Biochem. 80:703-732.8/22/2020 4:01:05 PM8/22/2020 4:01:05 PMType    Name    Media Type    File Size    Modified NIGMS image 24Sept12    Other 60939 KB 9/26/2020 10:28 PM Harris, Donald (NIH/NIGMS) [C Just so I?m clear: As STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{3E693FD7-64E8-4C53-B80F-EEEB7E4C47B9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
343223418Shortly after a pregnant woman gives birth, her breasts start to secrete milk. This process is triggered by hormonal and genetic cues, including the protein Elf5. Scientists discovered that Elf5 also has another job--it staves off cancer. Early in the development of breast cancer, human breast cells often lose Elf5 proteins. Cells without Elf5 change shape and spread readily--properties associated with metastasis. This image shows cells in the mouse mammary gland that are lacking Elf5, leading to the overproduction of other proteins (red) that increase the likelihood of metastasis.8/22/2020 4:13:22 PM8/22/2020 4:13:22 PMType    Name    Media Type    File Size    Modified Rumela_300dpi    Other 12314 KB 9/26/2020 10:32 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{21A2AB31-1A11-45C6-9FDA-9C8EF7162120}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
343423419Influenza (flu) virus proteins in the act of self-replication. Viral nucleoprotein (blue) encapsidates [encapsulates] the RNA genome (green). The influenza virus polymerase (orange) reads and copies the RNA genome. In the background is an image of influenza virus ribonucleoprotein complexes observed using cryo-electron microscopy. This image is from a November 2012 <a href=http://www.eurekalert.org/pub_releases/2012-11/sri-sri112012.php target="blank"> <em>News Release</em></a>.8/22/2020 4:28:48 PM8/22/2020 4:28:48 PMType    Name    Media Type    File Size    Modified Flu_virus_proteins_    High 660 KB 6/3/2016 3:29 PM aamishral2 (NIH/NIGMS) [C In the background is an image STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{77F0053D-8191-4175-9D50-055CE49F083C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
343623420This image shows the hierarchical ontology of genes, cellular components and processes derived from large genomic datasets. From Dutkowski et al. <a href= "http://www.ncbi.nlm.nih.gov/pubmed/23242164" target="_blank">A gene ontology inferred from molecular networks </a>Nat Biotechnol. 2013 Jan;31(1):38-45. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3437">image 3437</a>.8/22/2020 4:38:22 PM8/22/2020 4:38:22 PMType    Name    Media Type    File Size    Modified nexo_image_300dpi_no_text_T    Thumbnail 4 KB 6/3/2016 3:29 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{7D6D8D19-27F0-4C24-82CC-9AD3D499FA8A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
343723421This image shows the hierarchical ontology of genes, cellular components and processes derived from large genomic datasets. From Dutkowski et al. <a href= "http://www.ncbi.nlm.nih.gov/pubmed/23242164" target="_blank">A gene ontology inferred from molecular networks </a>Nat Biotechnol. 2013 Jan;31(1):38-45. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3436">image 3436</a>.8/22/2020 4:42:01 PM8/22/2020 4:42:01 PMType    Name    Media Type    File Size    Modified NeXO_300dpi_L    Low 69 KB 6/3/2016 3:29 PM aamishral2 (NIH/NIGMS) [C From Dutkowski et al. <a href STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{18E1FF8B-85D6-4F50-B7CE-4ED55E15A013}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
343823422The chemical structure of the morphine molecule8/22/2020 4:44:39 PM8/22/2020 4:44:39 PMType    Name    Media Type    File Size    Modified Morphine_structure_M    Medium 57 KB 6/3/2016 3:29 PM aamishral2 (NIH/NIGMS) [C Toni M. Kutchan and R. Howard STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{6EE205B7-C53B-4A56-B1E5-DB767CF5273F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
344023423During embryonic development, transcription factors (proteins that regulate gene expression) govern the differentiation of cells into separate tissues and organs. Researchers at Cincinnati Children's Hospital Medical Center used mice to study the development of certain internal organs, including the liver, pancreas, duodenum (beginning part of the small intestine), gall bladder and bile ducts. They discovered that transcription factor Sox17 guides some cells to develop into liver cells and others to become part of the pancreas or biliary system (gall bladder, bile ducts and associated structures). The separation of these two distinct cell types (liver versus pancreas/biliary system) is complete by embryonic day 8.5 in mice. The transcription factors PDX1 and Hes1 are also known to be involved in embryonic development of the pancreas and biliary system. This image shows mouse cells at embryonic day 10.5. The green areas show cells that will develop into the pancreas and/or duodenum(PDX1 is labeled green). The blue area near the bottom will become the gall bladder and the connecting tubes (common duct and cystic duct) that attach the gall bladder to the liver and pancreas (Sox17 is labeled blue). The transcription factor Hes1 is labeled red. The image was not published. A similar image (different plane of the section) was published in: <b>Sox17 Regulates Organ Lineage Segregation of Ventral Foregut Progenitor Cells</b> Jason R. Spence, Alex W. Lange, Suh-Chin J. Lin, Klaus H. Kaestner, Andrew M. Lowy, Injune Kim, Jeffrey A. Whitsett and James M. Wells, Developmental Cell, Volume 17, Issue 1, 62-74, 21 July 2009. doi:10.1016/j.devcel.2009.05.0128/22/2020 5:03:27 PM8/22/2020 5:03:27 PMType    Name    Media Type    File Size    Modified e10-5_sox_hes_pdx    Other 26400 KB 9/26/2020 10:34 PM Harris, Donald (NIH/NIGMS) [C If so, and if it?s not STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{82850322-6E67-4E74-9AB5-AA92C974E1F0}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
344223424These images show three stages of cell division in Xenopus XL177 cells, which are derived from tadpole epithelial cells. They are (from top): metaphase, anaphase and telophase. The microtubules are green and the chromosomes are blue. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3443">image 3443</a>.8/22/2020 5:25:02 PM8/22/2020 5:25:02 PMType    Name    Media Type    File Size    Modified mitotic1_M    Medium 94 KB 6/3/2016 3:29 PM aamishral2 (NIH/NIGMS) [C These images show three stages of cell division in Xenopus XL177 cells, which are derived from tadpole STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{385F83B3-C956-487B-9A75-4C353F0A940E}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
656823425These images illustrate a technique combining cryo-electron tomography and super-resolution fluorescence microscopy called correlative imaging by annotation with single molecules (CIASM). CIASM enables researchers to identify small structures and individual molecules in cells that they couldn’t using older techniques. 12/22/2020 3:22:47 PM12/22/2020 3:22:47 PMType    Name    Media Type    File Size    Modified Figure_2_72dpi    Thumbnail 63 KB 7/16/2020 3:27 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{93F7C98F-C6A0-4FA2-A019-AA17C2A1B17F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
6569234263D image of <i>Caulobacter</i> bacterium with various components highlighted: cell membranes (red and blue), protein shell (green), protein factories known as ribosomes (yellow), and storage granules (orange). 12/22/2020 3:22:13 PM12/22/2020 3:22:13 PMType    Name    Media Type    File Size    Modified cryo_em_caulobacter_thumb    Thumbnail 46 KB 7/16/2020 4:42 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{1F5C58D5-5216-4E76-AE82-A401F16B64DB}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
657023427Two highly stressed osteosarcoma cells are shown with a set of green droplet-like structures followed by a second set of magenta droplets. These droplets are composed of fluorescently labeled stress-response proteins, either G3BP or UBQLN2 (Ubiquilin-2). Each protein is undergoing a fascinating process, called phase separation, in which a non-membrane bound compartment of the cytoplasm emerges with a distinct environment from the surrounding cytoplasm. Subsequently, the proteins fuse with like proteins to form larger droplets, in much the same way that raindrops merge on a car’s windshield. 2/16/2021 8:21:25 PM2/16/2021 8:21:25 PMType    Name    Media Type    File Size    Modified Riley_GFP_Competition_thumb    Thumbnail 46 KB 7/16/2020 5:04 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{6FEA0B4F-A36D-4751-8D87-323A53C0F5D8}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
657123428Multiple actin filaments (magenta) are organized around a dynamin helical polymer (rainbow colored) in this model derived from cryo-electron tomography. By bundling actin, dynamin increases the strength of a cell’s skeleton and plays a role in cell-cell fusion, a process involved in conception, development, and regeneration. 12/22/2020 3:21:14 PM12/22/2020 3:21:14 PMType    Name    Media Type    File Size    Modified ActinFilamentImage_thumb    Thumbnail 33 KB 7/16/2020 5:23 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{CE410F5E-F218-4AB5-89F3-130512AFF2B4}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
657223429The 3D single-molecule super-resolution reconstruction of the entire nuclear lamina in a HeLa cell was acquired using the TILT3D platform. TILT3D combines a tilted light sheet with point-spread function (PSF) engineering to provide a flexible imaging platform for 3D single-molecule super-resolution imaging in mammalian cells. <br> See <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6573">6573</a> for 3 seperate views of this structure.<br>12/22/2020 3:20:41 PM12/22/2020 3:20:41 PMType    Name    Media Type    File Size    Modified NuclearLamina_300dpi_M    Medium 117 KB 7/16/2020 5:42 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{D065B67F-284D-48AA-98C1-513E4A756EF1}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
657323430Three views of the entire nuclear lamina of a HeLa cell produced by tilted light sheet 3D single-molecule super-resolution imaging using a platform termed TILT3D. <br> See <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6572">6572</a> for a 3D view of this structure.<br>12/22/2020 3:20:04 PM12/22/2020 3:20:04 PMType    Name    Media Type    File Size    Modified NuclearLamina_3views_300dpi_M    Medium 36 KB 7/16/2020 5:56 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{E72F4B33-2336-4F97-8B37-66D66E538673}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
657723431A 3D reconstruction of a transient receptor potential channel called TRPV5 that was created based on cryo-electron microscopy images. TRPV5 is primarily found in kidney cells and is essential for reabsorbing calcium into the blood.8/10/2020 11:36:21 PM8/10/2020 11:36:21 PMType    Name    Media Type    File Size    Modified TRP Channel_M    Medium 70 KB 8/18/2020 12:23 AM Harris, Donald (NIH/NIGMS) [C Dr. Moiseenkova-Bell’s research in this area has provided molecular details of how TRPV5 is modulated and STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{D77DB5BD-102C-43F3-9C74-4F2555FBCC79}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
6578234323D reconstructions of two stages in the assembly of the bacterial ribosome created from time-resolved cryo-electron microscopy images. Ribosomes translate genetic instructions into proteins.8/11/2020 12:06:18 AM8/11/2020 12:06:18 AMType    Name    Media Type    File Size    Modified TR Initiation (003)_thumb    Thumbnail 9 KB 8/18/2020 12:27 AM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{9B485B62-EAEE-40BE-81BE-1F5AE58B3220}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
248923433T cells engulf and digest cells displaying markers (or antigens) for retroviruses, such as HIV.9/18/2020 5:14:52 PM9/18/2020 5:14:52 PMType    Name    Media Type    File Size    Modified retrovirus_unlabeled_low    Low 104 KB 6/3/2016 3:12 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{9B49DCF9-CB59-4B8A-88FF-CF3FEE82D6AA}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232
249023434This illustration of an epoxide-opening cascade promoted by water emulates the proposed biosynthesis of some of the Red Tide toxins.9/18/2020 5:17:23 PM9/18/2020 5:17:23 PMType    Name    Media Type    File Size    Modified Water_cascade_thumb    Thumbnail 25 KB 6/3/2016 3:12 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibraryhttps://images.nigms.nih.gov/PublicAssets/Forms/AllItems.aspx0https://images.nigms.nih.govhtmlTruehttps://images.nigms.nih.gov{2631C4DA-12B6-470A-9C8A-BC2049812B4D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3232