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3445877This image of a mammalian epithelial cell, captured in metaphase, was the winning image in the high- and super-resolution microscopy category of the 2012 GE Healthcare Life Sciences Cell Imaging Competition. The image shows microtubules (red), kinetochores (green) and DNA (blue). The DNA is fixed in the process of being moved along the microtubules that form the structure of the spindle. The image was taken using the DeltaVision OMX imaging system, affectionately known as the "OMG" microscope, and was displayed on the NBC screen in New York's Times Square during the weekend of April 20-21, 2013. More information about the image is in a <em><a href="">news release</a></em> from Indiana University and a NIH Director's <em><a href="">blog post</a></em>. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to 7:47:14 PM11/22/2022 7:47:14 PMType    Name    Media Type    File Size    Modified 20120731_29_004_JSTOUT_S    Low 13 KB 8/30/2016 12:43 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{05E778D9-EC50-4DE0-B522-B3B83DC89C36}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2605901The human skin cells pictured contain genetic modifications that make them pluripotent, essentially equivalent to embryonic stem cells. A scientific team from the University of Wisconsin-Madison including researchers Junying Yu, James Thomson, and their colleagues produced the transformation by introducing a set of four genes into human fibroblasts, skin cells that are easy to obtain and grow in culture.10/30/2020 7:28:55 PM10/30/2020 7:28:55 PMType    Name    Media Type    File Size    Modified skin_cell_pluripotent07_1_M    Medium 364 KB 7/27/2016 11:39 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{846B41F6-0AAB-4160-9A8B-EF6F0C6272D7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3296527Researchers used fluorescence in situ hybridization (FISH) to confirm the presence of long range DNA-DNA interactions in mouse embryonic stem cells. Here, two loci labeled in green (Oct4) and red that are 13 Mb apart on linear DNA are frequently found to be in close proximity. DNA-DNA colocalizations like this are thought to both reflect and contribute to cell type specific gene expression programs.12/22/2020 10:54:56 PM12/22/2020 10:54:56 PMType    Name    Media Type    File Size    Modified Plath2_S    Low 31 KB 9/7/2016 5:14 PM Varkala, Venkat (NIH/NIGMS) [C Fluorescence in situ hybridization (FISH) in mouse STS_ListItem_DocumentLibrary{A989B78A-8FC5-488D-B776-F7EC38E2931B}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2707503An anchor cell (red) pushes through the basement membrane (green) that surrounds it. Some cells are able to push through the tough basement barrier to carry out important tasks--and so can cancer cells, when they spread from one part of the body to another. No one has been able to recreate basement membranes in the lab and they're hard to study in humans, so Duke University researchers turned to the simple worm <i>C. elegans</i>. The researchers identified two molecules that help certain cells orient themselves toward and then punch through the worm's basement membrane. Studying these molecules and the genes that control them could deepen our understanding of cancer spread. Featured in the September 16, 2009, issue of <a href= target="_blank"><em>Biomedical Beat</em></a>.8/6/2020 3:21:49 PM8/6/2020 3:21:49 PMType    Name    Media Type    File Size    Modified anchor_cell_L    Low 3 KB 6/3/2016 3:16 PM aamishral2 (NIH/NIGMS) [C Studying these molecules and the genes STS_ListItem_DocumentLibrary{5C256BD3-E678-45CC-933C-C98441003EE4}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3272731Mouse embryonic stem cells matured into this bundle of hair cells similar to the ones that transmit sound in the ear. These cells could one day be transplanted as a therapy for some forms of deafness, or they could be used to screen drugs to treat deafness. The hairs are shown at 23,000 times magnification via scanning electron microscopy. Image and caption information courtesy of the California Institute for Regenerative Medicine.12/22/2020 6:25:08 PM12/22/2020 6:25:08 PMType    Name    Media Type    File Size    Modified EarhaircellfromEScells_L    Low 7 KB 6/3/2016 3:25 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{A5C36457-F659-42BA-B403-50E555124A5F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1274768A typical animal cell, sliced open to reveal cross-sections of organelles. Appears in the NIGMS booklet <a href="" target="_blank"><i>Inside the Cell</i></a>.10/28/2020 4:26:16 PM10/28/2020 4:26:16 PMType    Name    Media Type    File Size    Modified ITC_EukaryoticCell_M    Medium 670 KB 6/3/2016 2:50 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{FA527259-AF0F-4976-BF59-5FA42D7FF97F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2801853Trajectories of single molecule labeled cell surface receptors. This is an example of NIH-supported research on single cell analysis. Related to <a href="">image 2798</a> , <a href="">image 2799</a>, <a href="">image 2800</a>, <a href="">image 2802</a> and <a href="">image 2803</a>.9/11/2020 4:15:56 PM9/11/2020 4:15:56 PMType    Name    Media Type    File Size    Modified nih11SingleMoleculeReceptors__2_S    Low 48 KB 8/24/2016 3:39 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{EBE2CF37-7DF8-463D-B36C-83086E86C45C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3443875These images show frog cells in interphase. The cells are Xenopus XL177 cells, which are derived from tadpole epithelial cells. The microtubules are green and the chromosomes are blue. Related to <a href="">image 3442</a>.8/22/2020 5:30:27 PM8/22/2020 5:30:27 PMType    Name    Media Type    File Size    Modified interphs    High 1903 KB 6/3/2016 3:29 PM aamishral2 (NIH/NIGMS) [C The microtubules are green and the STS_ListItem_DocumentLibrary{5CE69473-3A28-4887-B8C1-AA71A16B23A9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3332931Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a complex process. Recent research has shown that an actin-polymerizing factor called the Arp2/3 complex is the key component of the actin polymerization engine that drives amoeboid cell motility. ARPC3, a component of the Arp2/3 complex, plays a critical role in actin nucleation. In this photo, the ARPC3+/+ fibroblast cells were fixed and stained with Alexa 546 phalloidin for F-actin (red) and DAPI to visualize the nucleus (blue). ARPC3+/+ fibroblasts cells with lamellipodia leading edge. Related information available in a Stowers Institute <a href= target="_blank"> news release</a>. This image is part of a series of images; related to <a href="">image 3328</a> , <a href="">image 3329</a>, <a href="">image 3330</a>, <a href="">image 3331</a> and <a href="">image 3333</a>.12/23/2020 5:30:53 PM12/23/2020 5:30:53 PMType    Name    Media Type    File Size    Modified Pic-_5a_2_rs_S    Low 6 KB 3/23/2021 11:49 AM Walter, Taylor (NIH/NIGMS) [C In this photo, the ARPC3+/+ fibroblast cells were fixed and stained with STS_ListItem_DocumentLibrary{594A54CB-CF70-4918-B9C1-672340343B0C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
57601120The worm Caenorhabditis elegans is a popular laboratory animal because its small size and fairly simple body make it easy to study. Scientist use this small worm to answer many research questions in developmental biology, neurobiology and genetics. This image, which was taken with transmission electron microscopy (TEM), shows a cross-section through C. elegans, revealing various internal structures labeled in the image. You can find a high-resolution image without the annotations at image 5759 <a href="">in this entry</a>.<Br><Br> The image is from <a href="">a figure</a> in an article published in the journal eLife.1/15/2021 4:47:27 PM1/15/2021 4:47:27 PMType    Name    Media Type    File Size    Modified 5760_Celegans_S    Low 118 KB 3/28/2019 3:23 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{26773417-5411-4893-817B-3DAE79844B1F}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
65771278A 3D reconstruction of a transient receptor potential channel called TRPV5 that was created based on cryo-electron microscopy images. TRPV5 is primarily found in kidney cells and is essential for reabsorbing calcium into the blood.8/10/2020 11:36:21 PM8/10/2020 11:36:21 PMType    Name    Media Type    File Size    Modified TRP Channel_M    Medium 70 KB 8/18/2020 12:23 AM Harris, Donald (NIH/NIGMS) [C Dr. Moiseenkova-Bell’s research in this area has provided molecular details of how TRPV5 is modulated and STS_ListItem_DocumentLibrary{D77DB5BD-102C-43F3-9C74-4F2555FBCC79}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1010436A light microscope image of a cell from the endosperm of an African globe lily (<i>Scadoxus katherinae</i>). This is one frame of a time-lapse sequence that shows cell division in action. The lily is considered a good organism for studying cell division because its chromosomes are much thicker and easier to see than human ones. Staining shows microtubules in red and chromosomes in blue. Here, condensed chromosomes are clearly visible and are separating to form the cores of two new cells.5/9/2022 1:42:13 PM5/9/2022 1:42:13 PMType    Name    Media Type    File Size    Modified lilymit10_S    Low 15 KB 9/8/2016 2:24 PM Varkala, Venkat (NIH/NIGMS) [C Here, condensed chromosomes are clearly visible and are separating to form STS_ListItem_DocumentLibrary{13C7DFA2-E544-4331-9DCE-2395262F2E91}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2318587Pretty in pink, the enzyme histone deacetylase (HDA6) stands out against a background of blue-tinted DNA in the nucleus of an <i>Arabidopsis</i> plant cell. Here, HDA6 concentrates in the nucleolus (top center), where ribosomal RNA genes reside. The enzyme silences the ribosomal RNA genes from one parent while those from the other parent remain active. This chromosome-specific silencing of ribosomal RNA genes is an unusual phenomenon observed in hybrid plants. Featured in the June 20, 2006, issue of <a href= target="_blank"><em>Biomedical Beat</em></a>.10/29/2020 1:20:57 PM10/29/2020 1:20:57 PMType    Name    Media Type    File Size    Modified 2318_gene_S    Low 59 KB 3/29/2019 1:50 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{9AF8AC6D-4C9B-4230-A633-C6B5C804DB6C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2498690Cells progress through a cycle that consists of phases for growth (blue, green, yellow) and division (red). Cells become quiescent when they exit this cycle (purple). Featured in <a href= target="_blank"><i>Findings</i></a>, February 2003.3/4/2022 8:24:29 PM3/4/2022 8:24:29 PMType    Name    Media Type    File Size    Modified Cell_Cycle1_S    Low 35 KB 9/7/2016 4:19 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{78EBD835-9C97-44CB-AF98-FCCE4261D682}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2795917Ecteinascidin 743 (ET-743, brand name Yondelis), was discovered and isolated from a sea squirt, <i>Ecteinascidia turbinata</i>, by NIGMS grantee Kenneth Rinehart at the University of Illinois. It was synthesized by NIGMS grantees E.J. Corey and later by Samuel Danishefsky. It is being tested for the treatment of several types of cancer. Multiple versions of this structure are available as entries 2790-2797.2/22/2021 9:13:50 PM2/22/2021 9:13:50 PMType    Name    Media Type    File Size    Modified ET_743_2_L    Low 5 KB 6/3/2016 3:17 PM aamishral2 (NIH/NIGMS) [C It was synthesized by NIGMS grantees E.J. STS_ListItem_DocumentLibrary{86C9B538-29A6-4393-97EA-0AFC5C537F94}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3406941Phenylalanine tRNA showing the anticodon (yellow) and the amino acid, phenylalanine (blue and red spheres). The structure of phenylalanine tRNA is described in this journal article: Kristensen O, Reshetnikova L, Nissen P, Siboska G, Thirup S, Nyborg J. FEBS Lett. 1996 Dec 9;399(1-2):59-62.12/23/2020 8:47:36 PM12/23/2020 8:47:36 PMType    Name    Media Type    File Size    Modified -tRNAPhe-highres_S    Low 37 KB 9/14/2016 11:42 AM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{EF0971C4-B0FB-4781-9F31-720C0414208A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
37401180Nodes of Ranvier are short gaps in the myelin sheath surrounding myelinated nerve cells (axons). Myelin insulates axons, and the node of Ranvier is where the axon is exposed to the extracellular environment, allowing for the transmission of action potentials at these nodes via ion flows between the inside and outside of the axon. The image shows a cross-section through the node, with the surrounding ECM encasing and supporting the axon shown in cyan.12/17/2020 4:42:11 PM12/17/2020 4:42:11 PMType    Name    Media Type    File Size    Modified Node_of_Ranvier2    High 929 KB 6/3/2016 3:40 PM aamishral2 (NIH/NIGMS) [C Nodes of Ranvier are short gaps in STS_ListItem_DocumentLibrary{8F452BFD-D560-46A0-B945-E3470BDBDD41}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68071231Fruit fly (<em>Drosophila melanogaster</em>) ovaries with DNA shown in magenta and actin filaments shown in light blue. This image was captured using a confocal laser scanning microscope. <Br><Br> Related to image <a href="">6806</a>. 1/21/2022 3:54:37 PM1/21/2022 3:54:37 PMType    Name    Media Type    File Size    Modified 6807_M    Medium 503 KB 2/11/2022 2:22 PM Crowley, Rachel (NIH/NIGMS) [E The image was acquired on a Nikon STS_ListItem_DocumentLibrary{D9DE9B13-7DC9-4BB0-AA55-E415609A5F44}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3288866These smooth muscle cells were derived from human embryonic stem cells. The nuclei are stained blue, and the proteins of the cytoskeleton are stained green. Image and caption information courtesy of the California Institute for Regenerative Medicine.12/22/2020 10:50:50 PM12/22/2020 10:50:50 PMType    Name    Media Type    File Size    Modified SmoothmusclefromhumanEScells_L    Low 4 KB 6/3/2016 3:25 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{A4F77106-4DAF-4AE7-99E7-A64ACE79D60C}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68991301High-resolution time lapse of epithelial (skin) cell migration and wound healing. It shows an image taken every 13 seconds over the course of almost 14 minutes. The images were captured with quantitative orientation-independent differential interference contrast (DIC) microscope (left) and a conventional DIC microscope (right). <Br><Br>More information about the research that produced this video can be found in the <em>Journal of Microscopy</em> paper <a href="">“An Orientation-Independent DIC Microscope Allows High Resolution Imaging of Epithelial Cell Migration and Wound Healing in a Cnidarian Model”</a> by Malamy and Shribak. 6/30/2022 4:45:48 PM6/30/2022 4:45:48 PMType    Name    Media Type    File Size    Modified circularlamellipodia    High 17708 KB 6/30/2022 3:03 PM Crowley, Rachel (NIH/NIGMS) [E STS_ListItem_DocumentLibrary{497BC427-08F6-402E-B25B-3FF48F096460}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3390740The small intestine is where most of our nutrients from the food we eat are absorbed into the bloodstream. The walls of the intestine contain small finger-like projections called villi which increase the organ's surface area, enhancing nutrient absorption. It consists of the duodenum, which connects to the stomach, the jejenum and the ileum, which connects with the large intestine. Related to <a href="" target=_blank>image 3389</a> .12/23/2020 8:05:19 PM12/23/2020 8:05:19 PMType    Name    Media Type    File Size    Modified NCMIR_intestine-2_L    Low 28 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS) [C The small intestine is where most STS_ListItem_DocumentLibrary{A08D409D-7110-489B-8548-C499D3A28774}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3412539Active Site of E. coli response regulator PhoB12/23/2020 8:56:09 PM12/23/2020 8:56:09 PMType    Name    Media Type    File Size    Modified PhoB_hires_copy_M    Medium 189 KB 6/3/2016 3:28 PM aamishral2 (NIH/NIGMS) [C I have an image at 8,000 x STS_ListItem_DocumentLibrary{6EE05E04-C77C-409C-9469-654526ACE090}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2553695Arranging exons in different patterns, called alternative splicing, enables cells to make different proteins from a single gene. Featured in <a href= target="_blank"><i>The New Genetics</i></a>.3/4/2022 7:39:29 PM3/4/2022 7:39:29 PMType    Name    Media Type    File Size    Modified Alternative_Splicing_with_labels_S    Low 48 KB 8/25/2016 5:53 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{316509E3-8F9C-4A42-B17E-9024C0A51F6D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
68901345Microtubules (magenta) in neurons of the hippocampus, a part of the brain involved in learning and memory. Microtubules are strong, hollow fibers that provide structural support to cells. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="">6889</a>, <a href="">6891</a>, and <a href="">6892</a>.4/4/2023 8:30:37 PM4/4/2023 8:30:37 PMType    Name    Media Type    File Size    Modified Microtubules_S    Low 27 KB 4/4/2022 10:57 AM Bigler, Abbey (NIH/NIGMS) [C Let me know if this is good or if STS_ListItem_DocumentLibrary{669EF01C-7579-40A0-B4AD-BB86AF96AA93}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67671222CCD-1 is an enzyme produced by the bacterium <em>Clostridioides difficile</em> that helps it resist antibiotics. Using X-ray crystallography, researchers determined the structure of a complex between CCD-1 and the antibiotic cefotaxime (purple, yellow, and blue molecule). The structure revealed that CCD-1 provides extensive hydrogen bonding (shown as dotted lines) and stabilization of the antibiotic in the active site, leading to efficient degradation of the antibiotic. <Br><Br> Related to images <a href="/Pages/DetailPage.aspx?imageID2=6764">6764</a>, <a href="/Pages/DetailPage.aspx?imageID2=6765">6765</a>, and <a href="/Pages/DetailPage.aspx?imageID2=6766">6766</a>.5/16/2022 3:26:06 PM5/16/2022 3:26:06 PMType    Name    Media Type    File Size    Modified Space-fillingModelCCD-1_L    Low 12 KB 9/21/2021 4:49 PM Dolan, Lauren (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{DC0297AE-E276-460D-AA55-B9F0AD00D6B9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2791913Ecteinascidin 743 (ET-743, brand name Yondelis), was discovered and isolated from a sea squirt, <i>Ecteinascidia turbinata</i>, by NIGMS grantee Kenneth Rinehart at the University of Illinois. It was synthesized by NIGMS grantees E.J. Corey and later by Samuel Danishefsky. It is being tested for the treatment of several types of cancer. Multiple versions of this structure are available as entries 2790-2797.2/22/2021 9:16:48 PM2/22/2021 9:16:48 PMType    Name    Media Type    File Size    Modified ET743_withhydrogens2_M    Medium 15 KB 6/3/2016 3:17 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{7E9FE313-7ECC-410F-8624-D1F7D0E636A4}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
34971149Wound healing requires the action of stem cells. In mice that lack the Sept2/ARTS gene, stem cells involved in wound healing live longer and wounds heal faster and more thoroughly than in normal mice. This confocal microscopy image from a mouse lacking the Sept2/ARTS gene shows a tail wound in the process of healing. See more information in the press release from Rockefeller University ( and the article in Science (<br<</br>Related to images 3498 and 3500.9/9/2020 2:55:38 AM9/9/2020 2:55:38 AMType    Name    Media Type    File Size    Modified Steller1    High 505 KB 6/3/2016 3:30 PM aamishral2 (NIH/NIGMS) [C br<</br>Related to images 3498 and 3500 STS_ListItem_DocumentLibrary{C569D568-2C7B-41A2-A222-B70E85E15374}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2304456Gram-negative bacteria perform molecular acrobatics just to eat. Because they're encased by two membranes, they must haul nutrients across both. To test one theory of how the bacteria manage this feat, researchers used computer simulations of two proteins involved in importing vitamin B12. Here, the protein (red) anchored in the inner membrane of bacteria tugs on a much larger protein (green and blue) in the outer membrane. Part of the larger protein unwinds, creating a pore through which the vitamin can pass. Featured in the July 18, 2007, issue of <a href= target="_blank"><em>Biomedical Beat</em></a>. Note: You may need to download the free <a href="" target="_blank">Quicktime</a> player to view the movie.10/29/2020 12:42:09 PM10/29/2020 12:42:09 PMType    Name    Media Type    File Size    Modified btub-2.5Ans_M    High 3807 KB 1/22/2020 8:47 PM Varkala, Venkat (NIH/NIGMS) [C To test one theory of how the STS_ListItem_DocumentLibrary{60F22E99-F008-4FFE-A053-16B37BA426C2}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2311653This web-like structure shows the abnormal accumulation of cholesterol in a mouse brain cell that contains an aberrant protein linked to Huntington's disease, a fatal condition marked by a progressive degeneration of brain nerve cells. While the gene underlying the disease has been identified, little is known about how it leads to such neuronal damage. But the discovery that cholesterol builds up in mouse brain cells expressing the Huntington's protein could offer new clues for understanding the mechanism of the disease in humans. Featured in the December 19, 2006, issue of <a href= target="_blank"><em>Biomedical Beat</em></a>.10/29/2020 1:00:19 PM10/29/2020 1:00:19 PMType    Name    Media Type    File Size    Modified 2311_cholesterol_in_mouse_brain_cell_S    Low 72 KB 3/29/2019 1:53 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{40C466BA-6519-4523-8F67-829B38B64156}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69721350The SARS-CoV-2 virus (the virus that causes COVID-19) has a spike protein that it uses like a tool to break into and infect cells. On its own, the spike protein is harmless and can be used as a tool to train your immune system to defend against the virus. <Br><Br> Step 1: Scientists make copies of mRNA with instructions that tell the human body how to make only the outer spike protein of SARS-CoV-2. <Br><Br> Step 2: mRNA is packaged inside tiny globules called lipid nanoparticles. Lipids (fatty acids) are used as the vehicle because they: Protect the mRNA from breaking down Help it pass through cell membranes and into the body's cells <Br><Br> Step 3: The vaccine's mRNA instructions pass into muscle cells (near where a vaccine injection is given), and those muscle cells make copies of the spike protein. <Br><Br> Step 4: Though the spikes are harmless, the body’s immune system recognizes them as antigens (foreign substances) and produces targeted antibodies to defend against them. <Br><Br> Step 5: The body eliminates the vaccine material. Special white blood cells called memory cells "remember" the spike protein and which antibodies to make if they happen upon the spike again. <Br><Br> Step 6: If SARS-CoV-2 (and its telltale spike proteins) enter a vaccinated person's body, the immune system reacts with antibodies that defend against infection more swiftly than it otherwise could if it had never seen the spike protein. <Br><Br> Featured in <a href="">“<em>Pathways:</em> Vaccine Science.”</a> 5/13/2024 5:14:37 PM5/13/2024 5:14:37 PMType    Name    Media Type    File Size    Modified Journey of an mRNA Vaccine_S    Low 54 KB 11/7/2023 9:22 AM Crowley, Rachel (NIH/NIGMS) [E STS_ListItem_DocumentLibrary{A0D98018-1AF5-4488-A9F4-9845F6C44226}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2441618<i>Hydra magnipapillata</i> is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis.7/20/2021 2:20:35 PM7/20/2021 2:20:35 PMType    Name    Media Type    File Size    Modified D20_2931-2    High 416 KB 6/3/2016 3:11 PM aamishral2 (NIH/NIGMS) [C I sent the images for that purpose STS_ListItem_DocumentLibrary{DA359322-34AC-40B3-98FF-849B276875E9}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2404797Crystals of bovine milk alpha-lactalbumin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures.8/6/2020 7:02:27 PM8/6/2020 7:02:27 PMType    Name    Media Type    File Size    Modified f06K_bovine_milk_alpha-lactalbumin1_S    Low 33 KB 9/7/2016 3:29 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{F1FFCB10-15D1-4EE0-9091-707F43B87840}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2780719This is a magnified view of an <i>Arabidopsis thaliana</i> leaf eight days after being infected with the pathogen <i>Hyaloperonospora arabidopsidis</i>, which is closely related to crop pathogens that cause 'downy mildew' diseases. It is also more distantly related to the agent that caused the Irish potato famine. The veins of the leaf are light blue; in darker blue are the pathogen's hyphae growing through the leaf. The small round blobs along the length of the hyphae are called haustoria; each is invading a single plant cell to suck nutrients from the cell. Jeff Dangl and other NIGMS-supported researchers investigate how this pathogen and other like it use virulence mechanisms to suppress host defense and help the pathogens grow.8/28/2020 6:45:24 PM8/28/2020 6:45:24 PMType    Name    Media Type    File Size    Modified hyphae3Hp_080714_S    Low 34 KB 9/7/2016 2:47 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{C3E7A195-2670-44FA-B455-6BC2ABF2B316}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1017443A light microscope image of a cell from the endosperm of an African globe lily (<i>Scadoxus katherinae</i>). This is one frame of a time-lapse sequence that shows cell division in action. The lily is considered a good organism for studying cell division because its chromosomes are much thicker and easier to see than human ones. Staining shows microtubules in red and chromosomes in blue. Here, condensed chromosomes are clearly visible and have lined up in the middle of the dividing cell.5/9/2022 1:46:58 PM5/9/2022 1:46:58 PMType    Name    Media Type    File Size    Modified lilymit7_S    Low 10 KB 9/8/2016 2:37 PM Varkala, Venkat (NIH/NIGMS) [C Here, condensed chromosomes are clearly visible and have lined up in the STS_ListItem_DocumentLibrary{7950E1EF-8698-4948-87BF-364CE02E8679}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69021303An <em> Arachnoidiscus</em> diatom with a diameter of 190µm. Diatoms are microscopic algae that have cell walls made of silica, which is the strongest known biological material relative to its density. In <em> Arachnoidiscus</em>, the cell wall is a radially symmetric pillbox-like shell composed of overlapping halves that contain intricate and delicate patterns. Sometimes, <em> Arachnoidiscus</em> is called “a wheel of glass.” <Br><Br> This image was taken with the orientation-independent differential interference contrast microscope. 7/13/2022 8:00:33 PM7/13/2022 8:00:33 PMType    Name    Media Type    File Size    Modified Fourth of July_S    Low 40 KB 7/13/2022 4:09 PM Bigler, Abbey (NIH/NIGMS) [C Fourth of July    High 213 KB STS_ListItem_DocumentLibrary{061D17CD-3B20-4996-B7BC-CC797BDA0A6D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
35971089A study published in March 2012 used cryo-electron microscopy to determine the structure of the DNA replication origin recognition complex (ORC), a semi-circular, protein complex (yellow) that recognizes and binds DNA to start the replication process. The ORC appears to wrap around and bend approximately 70 base pairs of double stranded DNA (red and blue). Also shown is the protein Cdc6 (green), which is also involved in the initiation of DNA replication. Related to video <a href=><i>3307</i></a> that shows the structure from different angles. From a Brookhaven National Laboratory <a href= target="_blank">news release</a>, "Study Reveals How Protein Machinery Binds and Wraps DNA to Start Replication." 10/19/2020 6:35:19 AM10/19/2020 6:35:19 AMType    Name    Media Type    File Size    Modified 3597_DNA_replication_origin_recognition_complex__ORC_S    Low 132 KB 3/28/2019 4:08 PM Constantinides STS_ListItem_DocumentLibrary{B3B34891-56E7-4C4C-AC4A-53B710F155A1}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2727714Myotonic dystrophy is thought to be caused by the binding of a protein called Mbnl1 to abnormal RNA repeats. In these two images of the same muscle precursor cell, the top image shows the location of the Mbnl1 splicing factor (green) and the bottom image shows the location of RNA repeats (red) inside the cell nucleus (blue). The white arrows point to two large foci in the cell nucleus where Mbnl1 is sequestered with RNA. This image was featured in the February 17, 2010, issue of <a href= target="_blank"><i>Biomedical Beat</i></a>.8/12/2020 4:48:51 PM8/12/2020 4:48:51 PMType    Name    Media Type    File Size    Modified myotonic_big_S    Low 10 KB 9/7/2016 5:43 PM Varkala, Venkat (NIH/NIGMS) [C Myotonic dystrophy is thought to be caused STS_ListItem_DocumentLibrary{A87EC4AE-1ECD-4CE1-A928-A63EA1FD60D7}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2403796A crystal of pig trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures.8/6/2020 6:56:52 PM8/6/2020 6:56:52 PMType    Name    Media Type    File Size    Modified f06I_porcine_trypsin1_S    Low 36 KB 9/7/2016 3:28 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{FD3B2330-B470-450E-8237-E8DF645F32E5}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
35731155Scientists revealed a detailed image of the genetic defect that causes myotonic dystrophy type 2 and used that information to design drug candidates to counteract the disease. More information about the research behind this image can be found in a <a href="" target=_blank>Biomedical Beat</a> Blog posting from January 2014.10/5/2020 5:50:20 AM10/5/2020 5:50:20 AMType    Name    Media Type    File Size    Modified 3573_Disney_acsimage_thumbnail    Thumbnail 57 KB 3/12/2019 12:25 PM Constantinides, Stephen (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{23107167-597E-46A9-BAF0-3B572CEF8896}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
67881288Meiosis is used to make sperm and egg cells. During meiosis, a cell's chromosomes are copied once, but the cell divides twice. During mitosis, the chromosomes are copied once, and the cell divides once. For simplicity, cells are illustrated with only three pairs of chromosomes.<Br><Br> See image <a href="">1333</a> for an unlabeled version of this illustration.1/21/2022 4:01:54 PM1/21/2022 4:01:54 PMType    Name    Media Type    File Size    Modified ITC_MitoMeio_layout (1)_M    Medium 45 KB 12/1/2021 2:08 PM Crowley, Rachel (NIH/NIGMS) [E STS_ListItem_DocumentLibrary{9B45CCDD-6A3A-4182-A4F5-92C942058028}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
65531317Floral pattern emerging as two bacterial species, motile <i>Acinetobacter baylyi</i> (red) and non-motile <i>Escherichia coli</i> (green), are grown together for 48 hours on 1% agar surface from a small inoculum in the center of a Petri dish. <br><br> See <a href="">6557</a> for a photo of this process at 24 hours on 0.75% agar surface. <br> See <a href="">6555</a> for another photo of this process at 48 hours on 1% agar surface. <br> See <a href="">6556</a> for a photo of this process at 72 hours on 0.5% agar surface.<br> See <a href="">6550</a> for a video of this process.12/21/2020 8:13:21 PM12/21/2020 8:13:21 PMType    Name    Media Type    File Size    Modified v_1200_LowRes    Low 108 KB 3/23/2020 10:52 AM Harris, Donald (NIH/NIGMS) [C Floral pattern in a mixture of STS_ListItem_DocumentLibrary{6856F041-1361-4783-9B60-D14068A564E4}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2561892Histone proteins loop together with double-stranded DNA to form a structure that resembles beads on a string. See image 2560 for an unlabeled version of this illustration. Featured in <a href= target="_blank"><i>The New Genetics</i></a>.10/23/2020 7:26:47 PM10/23/2020 7:26:47 PMType    Name    Media Type    File Size    Modified Histones_with_labels_S    Low 56 KB 8/26/2016 3:10 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{3D67E801-82D8-4C50-9345-CD6E5A25A8AF}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
65731277Three views of the entire nuclear lamina of a HeLa cell produced by tilted light sheet 3D single-molecule super-resolution imaging using a platform termed TILT3D. <br> See <a href="">6572</a> for a 3D view of this structure.<br>12/22/2020 3:20:04 PM12/22/2020 3:20:04 PMType    Name    Media Type    File Size    Modified NuclearLamina_3views_300dpi_M    Medium 36 KB 7/16/2020 5:56 PM Harris, Donald (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{E72F4B33-2336-4F97-8B37-66D66E538673}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2365789A global "map of the protein structure universe." The Berkeley Structural Genomics Center has developed a method to visualize the vast universe of protein structures in which proteins of similar structure are located close together and those of different structures far away in the space. This map, constructed using about 500 of the most common protein folds, reveals a highly non-uniform distribution, and shows segregation between four elongated regions corresponding to four different protein classes (shown in four different colors). Such a representation reveals a high-level of organization of the protein structure universe.10/29/2020 4:16:23 PM10/29/2020 4:16:23 PMType    Name    Media Type    File Size    Modified hi_map500_M    Medium 78 KB 6/3/2016 3:09 PM aamishral2 (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{2388E2EB-3730-4F33-A049-087CFC2A4AFF}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3733981The image visualizes a part of the yeast molecular interaction network. The lines in the network represent connections among genes (shown as little dots) and different-colored networks indicate subnetworks, for instance, those in specific locations or pathways in the cell. Researchers use gene or protein expression data to build these networks; the network shown here was visualized with a program called <a href="">Cytoscape</a>. By following changes in the architectures of these networks in response to altered environmental conditions, scientists can home in on those genes that become central "hubs" (highly connected genes), for example, when a cell encounters stress. They can then further investigate the precise role of these genes to uncover how a cell's molecular machinery deals with stress or other factors. Related to images <a href="">3730</a> and <a href="">3732</a>.12/17/2020 4:34:35 PM12/17/2020 4:34:35 PMType    Name    Media Type    File Size    Modified cytoscape23_L    Low 609 KB 6/3/2016 3:40 PM aamishral2 (NIH/NIGMS) [C They can then further investigate the STS_ListItem_DocumentLibrary{80B3929B-B41A-4C70-B3C1-19365D9D2E94}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
2749846This image integrates the thousands of known molecular and genetic interactions happening inside our bodies using a computer program called Cytoscape. Images like this are known as network wiring diagrams, but Cytoscape creator Trey Ideker somewhat jokingly calls them "hairballs" because they can be so complicated, intricate and hard to tease apart. Cytoscape comes with tools to help scientists study specific interactions, such as differences between species or between sick and diseased cells. Related to <a href="">image 2737</a>. Featured in the June 16, 2010, issue of <a href= target="_blank"><em>Biomedical Beat</em></a>.8/12/2020 6:44:41 PM8/12/2020 6:44:41 PMType    Name    Media Type    File Size    Modified network_map_23_S    Low 88 KB 9/7/2016 2:25 PM Varkala, Venkat (NIH/NIGMS) [C Images like this are known as STS_ListItem_DocumentLibrary{2C441A06-3184-4A25-8DE1-C55F3EC23FBE}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
69851304<em> Drosophila </em> adult brain showing that an adipokine (fat hormone) generates a response from neurons (aqua) and regulates insulin-producing neurons (red). <Br><Br>Related to images <a href="">6982</a>, <a href="">6983</a>, and <a href="">6984</a>.12/19/2023 9:06:13 PM12/19/2023 9:06:13 PMType    Name    Media Type    File Size    Modified Since the images are too large to attach I have uploaded them at this google drive link and you should be able to download it the link STS_ListItem_DocumentLibrary{B16A02E1-AF2B-43FE-A6EC-37FF25432F66}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
3344936Researchers have created artificial cilia that wave like the real thing. Zvonimir Dogic and his Brandeis University colleagues combined just a few cilia proteins to create cilia that are able to wave and sweep material around--although more slowly and simply than real ones. The researchers are using the lab-made cilia to study how the structures coordinate their movements and what happens when they don't move properly. Featured in the August 18, 2011, issue of <a href= target="_blank"><em>Biomedical Beat</em></a>.12/23/2020 5:39:06 PM12/23/2020 5:39:06 PMType    Name    Media Type    File Size    Modified nice_flagella_Rot_90deg_montage__reduced_    Medium 51 KB 2/22/2021 3:09 PM Dolan, Lauren (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{DF410754-C0AA-49ED-A56B-13204AB6771A}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
37451185Serum albumin (SA) is the most abundant protein in the blood plasma of mammals. SA has a characteristic heart-shape structure and is a highly versatile protein. It helps maintain normal water levels in our tissues and carries almost half of all calcium ions in human blood. SA also transports some hormones, nutrients and metals throughout the bloodstream. Despite being very similar to our own SA, those from other animals can cause some mild allergies in people. Therefore, some scientists study SAs from humans and other mammals to learn more about what subtle structural or other differences cause immune responses in the body. <Br><Br>Related to entries <a href=""> 3744</a> and <a href="">3746</a> 12/17/2020 5:40:23 PM12/17/2020 5:40:23 PMType    Name    Media Type    File Size    Modified albumin-rainbow-mode33_L    Low 194 KB 6/3/2016 3:40 PM aamishral2 (NIH/NIGMS) [C Please let me know if you STS_ListItem_DocumentLibrary{4CDB149D-EA57-443F-BAAE-4CBB0147A4E3}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131
1278444Two models for how material passes through the Golgi apparatus: the vesicular shuttle model and the cisternae maturation model. You can see animations of the two different models at <a href="" target="_blank"></a>. Appears in the NIGMS booklet <a href="" target="_blank"><i>Inside the Cell</i></a>.10/28/2020 4:37:04 PM10/28/2020 4:37:04 PMType    Name    Media Type    File Size    Modified ITC_GolgiTheories_S    Low 69 KB 8/24/2016 5:17 PM Varkala, Venkat (NIH/NIGMS) [C STS_ListItem_DocumentLibrary{8338FE7B-DE3A-4BB1-9AD3-842F7470380D}Sharepoint.DocumentSet~sitecollection/_catalogs/masterpage/Display Templates/Search/Item_PublicAsset.js3131