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3764
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The proteasome is a critical multiprotein complex in the cell that breaks down and recycles proteins that have become damaged or are no longer needed. This movie shows how a protein substrate (red) is bound through its ubiquitin chain (blue) to one of the ubiquitin receptors of the proteasome (Rpn10, yellow). The substrate's flexible engagement region then gets engaged by the AAA+ motor of the proteasome (cyan), which initiates mechanical pulling, unfolding and movement of the protein into the proteasome's interior for cleavage into shorter protein pieces called peptides. During movement of the substrate, its ubiquitin modification gets cleaved off by the deubiquitinase Rpn11 (green), which sits directly above the entrance to the AAA+ motor pore and acts as a gatekeeper to ensure efficient ubiquitin removal, a prerequisite for fast protein breakdown by the 26S proteasome.
12/17/2020 6:30:10 PM
12/17/2020 6:30:10 PM
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The structure of the pore-forming protein VDAC-1 from humans. This molecule mediates the flow of products needed for metabolism--in particular the export of ATP--across the outer membrane of mitochondria, the power plants for eukaryotic cells. VDAC-1 is involved in metabolism and the self-destruction of cells--two biological processes central to health. Relates to a <a href=http://www.nigms.nih.gov/News/Results/20080904_announce.htm target="_blank">September 4, 2008 news release</a>.
5/9/2022 1:29:10 PM
5/9/2022 1:29:10 PM
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If you want we also can
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The Golgi complex, also called the Golgi apparatus or, simply, the Golgi. This organelle receives newly made proteins and lipids from the ER, puts the finishing touches on them, addresses them, and sends them to their final destinations. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 4:29:29 PM
10/28/2020 4:29:29 PM
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ITC_Golgi_inset_Copy_M Medium 28 KB 10/28/2020 12:29 PM McCulley, Jennifer (NIH/NIDCD) [C
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These images illustrate a technique combining cryo-electron tomography and super-resolution fluorescence microscopy called correlative imaging by annotation with single molecules (CIASM). CIASM enables researchers to identify small structures and individual molecules in cells that they couldn’t using older techniques.
12/22/2020 3:22:47 PM
12/22/2020 3:22:47 PM
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Meiosis is the process whereby a cell reduces its chromosomes from diploid to haploid in creating eggs or sperm. See image 2546 for a labeled version of this illustration. Featured in <a href=http://publications.nigms.nih.gov/thenewgenetics/ target="_blank"><i>The New Genetics</i></a>.
10/16/2020 5:04:11 PM
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This image shows the long, branched structures (axons) of nerve cells. Running horizontally across the middle of the photo is an axon wrapped in rings made of actin protein (green), which plays important roles in nerve cells. The image was captured with a powerful microscopy technique that allows scientists to see single molecules in living cells in real time. The technique is called stochastic optical reconstruction microscopy (STORM). It is based on technology so revolutionary that its developers earned the 2014 Nobel Prize in Chemistry. More information about this image can be found in: K. Xu, G. Zhong, X. Zhuang. <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815867/" target="_blank">Actin, spectrin and associated proteins form a periodic cytoskeleton structure in axons</a>. Science 339, 452-456 (2013).
12/1/2020 6:12:00 PM
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STORM_6_L Low 121 KB 6/3/2016 3:38 PM aamishral2 (NIH/NIGMS) [C
It is based on technology so revolutionary that its developers earned the 2014 Nobel
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Fat tissue from the abdomen of a genetically mosaic adult fruit fly. Genetic mosaicism means that the fly has cells with different genotypes even though it formed from a single zygote. This specific mosaicism results in accumulation of a critical fly adipokine (blue-green) within the fat tissue cells that have reduced expression a key nutrient sensing gene (in left panel). The dotted line shows the cells lacking the gene that is present and functioning in the rest of the cells. Nuclei are labelled in magenta. This image was captured using a confocal microscope and shows a maximum intensity projection of many slices. <Br><Br>Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6982">6982</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6984">6984</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6985">6985</a>.
12/19/2023 7:15:52 PM
12/19/2023 7:15:52 PM
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This image was captured using a confocal microscope and shows a maximum intensity projection of many slices
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The nucleus of a degenerating human tendon cell, also known as a tenocyte. It has been color-coded based on the density of chromatin—a substance made up of DNA and proteins. Areas of low chromatin density are shown in blue, and areas of high chromatin density are shown in red. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6887">6887</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6888">6888</a>.
4/4/2023 8:31:20 PM
4/4/2023 8:31:20 PM
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Tenocyte_S Low 18 KB 4/4/2022 11:00 AM Bigler, Abbey (NIH/NIGMS) [C
Let me know if this is good or if you
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A <em>Trigonium</em> diatom imaged by a quantitative orientation-independent differential interference contrast (OI-DIC) microscope. Diatoms are single-celled photosynthetic algae with mineralized cell walls that contain silica and provide protection and support. These organisms form an important part of the plankton at the base of the marine and freshwater food chains. The width of this image is 90 μm. <Br><Br> More information about the microscopy that produced this image can be found in the <em>Journal of Microscopy</em> paper <a href="https://onlinelibrary.wiley.com/doi/10.1111/jmi.12682/">“An Orientation-Independent DIC Microscope Allows High Resolution Imaging of Epithelial Cell Migration and Wound Healing in a Cnidarian Model”</a> by Malamy and Shribak.
1/27/2023 9:46:30 PM
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Thin, hair-like biological structures called cilia are tiny but mighty. Each one, made up of more than 600 different proteins, works together with hundreds of others in a tightly-packed layer to move like a crowd at a ball game doing "the wave." Their synchronized motion helps sweep mucus from the lungs and usher eggs from the ovaries into the uterus. By controlling how fluid flows around an embryo, cilia also help ensure that organs like the heart develop on the correct side of your body.
9/9/2020 2:26:22 AM
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Dogic_video_thumbnail Thumbnail 21 KB 6/3/2016 3:30 PM aamishral2 (NIH/NIGMS) [C
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Floral pattern emerging as two bacterial species, motile <i>Acinetobacter baylyi</i> (red) and non-motile <i>Escherichia coli</i> (green), are grown together for 48 hours on 1% agar surface from a small inoculum in the center of a Petri dish. <br><br> See <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6557">6557</a> for a photo of this process at 24 hours on 0.75% agar surface. <br> See <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6553">6553</a> for another photo of this process at 48 hours on 1% agar surface. <br> See <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6556">6556</a> for a photo of this process at 72 hours on 0.5% agar surface. <br> See <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6550">6550</a> for a video of this process.
12/21/2020 8:15:42 PM
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Model of the enzyme aminopeptidase N from the human pathogen <i>Neisseria meningitidis</i>, which can cause meningitis epidemics. The structure provides insight on the active site of this important molecule.
10/29/2020 2:43:00 PM
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A nanometer-sized biosensor can detect a single deadly bacterium in tainted ground beef. How? Researchers attached nanoparticles, each packed with thousands of dye molecules, to an antibody that recognizes the microbe <i>E. coli</i> O157:H7. When the nanoball-antibody combo comes into contact with the <i>E. coli</i> bacterium, it glows. Here is the transition, a single bacterial cell glows brightly when it encounters nanoparticle-antibody biosensors, each packed with thousands of dye molecules. Featured in the March 15, 2005, issue of <a href=http://publications.nigms.nih.gov/biobeat/05-09-20/#1 target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 1:07:28 PM
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This image captures the spiral-shaped ovary of an anglerfish in cross-section. Once matured, these eggs will be released in a gelatinous, floating mass. For some species of anglerfish, this egg mass can be up to 3 feet long and include nearly 200,000 eggs. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.
11/22/2022 8:30:54 PM
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Researchers use cluster analysis to study protein shape and function. Each green circle represents one potential shape of the protein mitoNEET. The longer the blue line between two circles, the greater the differences between the shapes. Most shapes are similar; they fall into three clusters that are represented by the three images of the protein. From a Rice University <a href=http://www.eurekalert.org/pub_releases/2012-01/ru-rus012612.php target="_blank">news release</a>. Graduate student Elizabeth Baxter and Patricia Jennings, professor of chemistry and biochemistry at UCSD, collaborated with José Onuchic, a physicist at Rice University, on this work.
12/22/2020 10:54:21 PM
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Living primary mouse embryonic fibroblasts. Mitochondria (green) stained with the mitochondrial membrane potential indicator, rhodamine 123. Nuclei (blue) are stained with DAPI. Caption from a November 26, 2012 <a href= "http://www.uphs.upenn.edu/news/News_Releases/2012/11/energy/">news release </a> from U Penn (Penn Medicine).
8/22/2020 6:35:39 PM
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From: Kevin Foskett [mailto:foskett@mail.med.upenn.edu] Sent: Wednesday, May 15, 2013 11:14 AM To: Kreeger, Karen Subject: Re: Permission from NIGMS
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This image integrates the thousands of known molecular and genetic interactions happening inside our bodies using a computer program called Cytoscape. Images like this are known as network wiring diagrams, but Cytoscape creator Trey Ideker somewhat jokingly calls them "hairballs" because they can be so complicated, intricate and hard to tease apart. Cytoscape comes with tools to help scientists study specific interactions, such as differences between species or between sick and diseased cells. Related to <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=2737">image 2737</a>. Featured in the June 16, 2010, issue of <a href=http://publications.nigms.nih.gov/biobeat/10-06-16/index.html#1 target="_blank"><em>Biomedical Beat</em></a>.
8/12/2020 6:44:41 PM
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This microscopic image shows a chromatin fiber--a DNA molecule bound to naturally occurring proteins.
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Like a paint-by-numbers picture, painted probes tint individual human chromosomes by targeting specific DNA sequences. Chromosome 13 is colored green, chromosome 14 is in red and chromosome 15 is painted yellow. The image shows two examples of fused chromosomes--a pair of chromosomes 15 connected head-to-head (yellow dumbbell-shaped structure) and linked chromosomes 13 and 14 (green and red dumbbell). These fused chromosomes--called dicentric chromosomes--may cause fertility problems or other difficulties in people.
8/28/2020 5:52:08 PM
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What looks like a Native American dream catcher is really a network of social interactions within a community. The red dots along the inner and outer circles represent people, while the different colored lines represent direct contact between them. All connections originate from four individuals near the center of the graph. Modeling social networks can help researchers understand how diseases spread. Featured in the July 19, 2005, issue of <a href=http://publications.nigms.nih.gov/biobeat/05-07-19/#1 target="_blank"><em>Biomedical Beat</em></a>.
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Cells walk along body surfaces via tiny "feet," called focal adhesions, that connect with the extracellular matrix. Featured in <a href=http://www.nigms.nih.gov/Publications/Findings.htm target="_blank"><i>Findings</i></a>, March 2005.
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Microfluidic chips have many uses in biology labs. The one shown here was used by bioengineers to study bacteria, allowing the researchers to synchronize their fluorescing so they would blink in unison. See also entries 3266-3268. From a UC San Diego <a href=http://ucsdnews.ucsd.edu/pressreleases/researchers_create_living_neon_signs_composed_of_millions_of_glowing_bacter/ target="_blank">news release</a>, "Researchers create living 'neon signs' composed of millions of glowing bacteria."
12/22/2020 5:19:18 PM
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A typical animal cell, sliced open to reveal cross-sections of organelles. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 4:26:16 PM
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A cell in prophase, near the start of mitosis: In the nucleus, chromosomes condense and become visible. In the cytoplasm, the spindle forms. Mitosis is responsible for growth and development, as well as for replacing injured or worn out cells throughout the body. For simplicity, mitosis is illustrated here with only six chromosomes. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 8:10:12 PM
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Professor Marc Zimmer's family pets, including these fish, glow in the dark in response to blue light. Featured in the September 2009 issue of <a href=http://publications.nigms.nih.gov/findings/index.htm target="_blank"><i>Findings</i></a>.
11/6/2020 9:11:31 PM
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<i>Bacillus anthracis</i> (anthrax) cells being killed by a fluorescent trans-translation inhibitor, which disrupts bacterial protein synthesis. The inhibitor is naturally fluorescent and looks blue when it is excited by ultraviolet light in the microscope. This is a black-and-white version of <a href="http://images.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3525">Image 3525</a>.
8/31/2020 5:16:14 AM
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i>Bacillus anthracis</i> (anthrax) cells being killed by a fluorescent
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This fruit fly spermatid recycles various molecules, including malformed or damaged proteins. Actin filaments (red) in the cell draw unwanted proteins toward a barrel-shaped structure called the proteasome (green clusters), which degrades the molecules into their basic parts for re-use. Featured in the May 16, 2013, issue of <em><a href="http://publications.nigms.nih.gov/biobeat/#1">Biomedical Beat</a></em>.
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Like a group of barnacles hanging onto a rock, these human cells hang onto a matrix coated glasss slide. Actin stress fibers, stained magenta, and the protein vinculin, stained green, make this adhesion possible. The fibroblast nuclei are stained blue. Featured in the May 16, 2013 issue of <em><a href="http://publications.nigms.nih.gov/biobeat/#5">Biomedical Beat</a></em>.
5/13/2022 12:01:53 PM
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Yeast make bread, beer and wine. And like us, yeast can reproduce sexually. A mother and father cell fuse and create one large cell that contains four offspring. When environmental conditions are favorable, the offspring are released, as shown here. Yeast are also a popular study subject for scientists. Research on yeast has yielded vast knowledge about basic cellular and molecular biology as well as about myriad human diseases, including colon cancer and various metabolic disorders. This image is part of the Life: Magnified collection, which was displayed in the Gateway Gallery at Washington Dulles International Airport June 3, 2014, to January 21, 2015. To see all 46 images in this exhibit, go to https://www.nigms.nih.gov/education/life-magnified/Pages/default.aspx.
11/22/2022 8:51:06 PM
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Learn about basic science, sometimes called “pure” or “fundamental” science, and how it contributes to the development of medical treatments. Discover more resources from NIGMS’ <a href="https://www.nigms.nih.gov/education/pathways/Pages/Home.aspx">Pathways</a> collaboration with Scholastic. View the <a href="https://www.youtube.com/watch?v=9Fg2uXLxtII&list=PL9fzcZ7JxMmZry8oLhKq9Iaf4EPVinIXf&index=3">video<img src="https://www.nigms.nih.gov/PublishingImages/exitdisclaimer.gif" alt="Link to external web site" style="border-width: 0px;"/></a> on YouTube for closed captioning.
12/4/2020 3:06:20 PM
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Various views of a zebrafish head with blood vessels shown in purple. Researchers often study zebrafish because they share many genes with humans, grow and reproduce quickly, and have see-through eggs and embryos, which make it easy to study early stages of development. <Br><Br> This video was captured using a light sheet microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6934">6934</a>.
3/28/2023 7:28:33 PM
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High-resolution time lapse of epithelial (skin) cell migration and wound healing. It shows an image taken every 13 seconds over the course of almost 14 minutes. The images were captured with quantitative orientation-independent differential interference contrast (DIC) microscope (left) and a conventional DIC microscope (right). <Br><Br>More information about the research that produced this video can be found in the <em>Journal of Microscopy</em> paper <a href="https://onlinelibrary.wiley.com/doi/10.1111/jmi.12682/">“An Orientation-Independent DIC Microscope Allows High Resolution Imaging of Epithelial Cell Migration and Wound Healing in a Cnidarian Model”</a> by Malamy and Shribak.
6/30/2022 4:45:48 PM
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Found in the journal, Nature, Chemical Biology 8, 366-374 (2012). Part of an image series: <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3413">image 3413</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3414">image 3414</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3415">image 3415</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3416">image 3416</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3417">image 3417</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=3418">image 3418</a>.
12/23/2020 11:13:50 PM
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During mitosis, spindle microtubules (red) attach to chromosome pairs (blue), directing them to the spindle equator. This midline alignment is critical for equal distribution of chromosomes in the dividing cell. Scientists are interested in how the protein kinase Plk1 (green) regulates this activity in human cells. Image is a volume projection of multiple deconvolved z-planes acquired with a Nikon widefield fluorescence microscope. This image was chosen as a winner of the 2016 NIH-funded research image call. Related to <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3059">image 5766</a>. <Br><Br> The research that led to this image was funded by NIGMS.
12/18/2020 6:01:41 PM
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Hippocampal cells in culture with neuron in green, showing hundreds of the small protrusions known as dendritic spines. The dendrites of other neurons are labeled in blue, and adjacent glial cells are shown in red.
7/13/2023 6:47:14 PM
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Nodes of Ranvier are short gaps in the myelin sheath surrounding myelinated nerve cells (axons). Myelin insulates axons, and the node of Ranvier is where the axon is exposed to the extracellular environment, allowing for the transmission of action potentials at these nodes via ion flows between the inside and outside of the axon. The image shows a cross-section through the node, with the surrounding ECM encasing and supporting the axon shown in cyan.
12/17/2020 4:42:11 PM
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As this cell was undergoing cell division, it was imaged with two microscopy techniques: differential interference contrast (DIC) and confocal. The DIC view appears in blue and shows the entire cell. The confocal view appears in pink and shows the chromosomes.
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Multicellular yeast called snowflake yeast that researchers created through many generations of directed evolution from unicellular yeast. Here, the researchers visualized nuclei in orange to help them study changes in how the yeast cells divided. Cell walls are shown in blue. This image was captured using spinning disk confocal microscopy. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6969">6969</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6970">6970</a>.
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He is the one who took the
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Real-time footage of <em>Caenorhabditis elegans</em>, a tiny roundworm, trapped by a carnivorous fungus, <em>Arthrobotrys dactyloides</em>. This fungus makes ring traps in response to the presence of <em>C. elegans</em>. When a worm enters a ring, the trap rapidly constricts so that the worm cannot move away, and the fungus then consumes the worm. The size of the imaged area is 0.7mm x 0.9mm. <Br><Br> This video was obtained with a polychromatic polarizing microscope (PPM) in white light that shows the polychromatic birefringent image with hue corresponding to the slow axis orientation. More information about PPM can be found in the <em>Scientific Reports</em> paper <a href="https://www.nature.com/articles/srep17340/">“Polychromatic Polarization Microscope: Bringing Colors to a Colorless World”</a> by Shribak.
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Multicellular yeast called snowflake yeast that researchers created through many generations of directed evolution from unicellular yeast. Cells are connected to one another by their cell walls, shown in blue. Stained cytoplasm (green) and membranes (magenta) show that the individual cells remain separate. This image was captured using spinning disk confocal microscopy. <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6969">6969</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6971">6971</a>.
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Learn about how bacteria and viruses differ, how they each can make you sick, and how they can or cannot be treated. Discover more resources from NIGMS’ <a href="https://www.nigms.nih.gov/education/pathways/Pages/Home.aspx">Pathways</a> collaboration with Scholastic. View the <a href="https://www.youtube.com/watch?v=hTWUV6azGXE">video<img src="https://www.nigms.nih.gov/PublishingImages/exitdisclaimer.gif" alt="Link to external web site" style="border-width: 0px;"/></a> on YouTube for closed captioning.
9/12/2022 3:13:25 PM
9/12/2022 3:13:25 PM
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Pathways_ Bacteria vs. Viruses_ What's the Difference_ High 15387 KB 12/3/2020 5:32 PM Walter, Taylor
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In many animals, the egg cell develops alongside sister cells. These sister cells are called nurse cells in the fruit fly (<em>Drosophila melanogaster</em>), and their job is to “nurse” an immature egg cell, or oocyte. Toward the end of oocyte development, the nurse cells transfer all their contents into the oocyte in a process called nurse cell dumping. This video captures this transfer, showing significant shape changes on the part of the nurse cells (blue), which are powered by wavelike activity of the protein myosin (red). Researchers created the video using a confocal laser scanning microscope. Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6753">6753</a>.
7/20/2021 3:43:33 PM
7/20/2021 3:43:33 PM
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Fruit fly nurse cell video (1) High 23777 KB 3/25/2021 4:51 PM Walter, Taylor (NIH/NIGMS) [C
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The nucleus of a human fibroblast cell with chromatin—a substance made up of DNA and proteins—shown in various colors. Fibroblasts are one of the most common types of cells in mammalian connective tissue, and they play a key role in wound healing and tissue repair. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6887">6887</a> and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6893">6893</a>.
4/4/2022 4:01:50 PM
4/4/2022 4:01:50 PM
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Viral RNA (red) in an RSV-infected cell. More information about the research behind this image can be found in a <a href="http://biobeat.nigms.nih.gov/2014/01/cool-image-visualizing-viral-activity/">Biomedical Beat Blog posting</a> from January 2014.
10/5/2020 5:40:18 AM
10/5/2020 5:40:18 AM
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RSV-infected_cell_L Low 11 KB 6/3/2016 3:32 PM aamishral2 (NIH/NIGMS) [C
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This illustration shows pathogenic bacteria behave like a Trojan horse: switching from antibiotic susceptibility to resistance during infection. Salmonella are vulnerable to antibiotics while circulating in the blood (depicted by fire on red blood cell) but are highly resistant when residing within host macrophages. This leads to treatment failure with the emergence of drug-resistant bacteria.<Br><Br> This image was chosen as a winner of the 2016 NIH-funded research image call, and the research was funded in part by NIGMS.
12/18/2020 5:59:09 PM
12/18/2020 5:59:09 PM
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26831610894_f3d948c0d7_o_M Medium 208 KB 7/21/2016 2:16 PM Varkala, Venkat (NIH/NIGMS) [C
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This image results from a research project to visualize which regions of the adult fruit fly (Drosophila) brain derive from each neural stem cell. First, researchers collected several thousand fruit fly larvae and fluorescently stained a random stem cell in the brain of each. The idea was to create a population of larvae in which each of the 100 or so neural stem cells was labeled at least once. When the larvae grew to adults, the researchers examined the flies’ brains using confocal microscopy. With this technique, the part of a fly’s brain that derived from a single, labeled stem cell “lights up.” The scientists photographed each brain and digitally colorized its lit-up area. By combining thousands of such photos, they created a 3-dimensional, color-coded map that shows which part of the Drosophila brain comes from each of its ~100 neural stem cells. In other words, each colored region shows which neurons are the progeny or “clones” of a single stem cell. This work established a hierarchical structure as well as nomenclature for the neurons in the Drosophila brain. Further research will relate functions to structures of the brain. Related to image <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3808">5868</a> and video<a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=3749"> 5843</a>
5/13/2022 12:38:45 PM
5/13/2022 12:38:45 PM
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5838_droso_x10_crop from Utah BTRR--Chris Johnson_S Low 166 KB 3/28/2019 2:31 PM Constantinides, Stephen
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A mouse brain that was genetically modified so that subpopulations of its neurons glow. Researchers often study mice because they share many genes with people and can shed light on biological processes, development, and diseases in humans. <Br><Br> This image was captured using a light sheet microscope. <Br><Br> Related to image <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6930">6930</a> and video <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6931">6931</a>.
3/28/2023 7:24:12 PM
3/28/2023 7:24:12 PM
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Green Mouse Brain_M Medium 466 KB 3/28/2023 1:26 PM Bigler, Abbey (NIH/NIGMS) [C
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Microtubules (magenta) in neurons of the hippocampus, a part of the brain involved in learning and memory. Microtubules are strong, hollow fibers that provide structural support to cells. This image was captured using Stochastic Optical Reconstruction Microscopy (STORM). <Br><Br> Related to images <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6889">6889</a>, <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6891">6891</a>, and <a href="https://images.nigms.nih.gov/pages/DetailPage.aspx?imageid2=6892">6892</a>.
4/4/2023 8:30:37 PM
4/4/2023 8:30:37 PM
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Microtubules_S Low 27 KB 4/4/2022 10:57 AM Bigler, Abbey (NIH/NIGMS) [C
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This illustration shows vesicle traffic inside a cell. The double membrane that bounds the nucleus flows into the ribosome-studded rough endoplasmic reticulum (purple), where membrane-embedded proteins are manufactured. Proteins are processed and lipids are manufactured in the smooth endoplasmic reticulum (blue) and Golgi apparatus (green). Vesicles that fuse with the cell membrane release their contents outside the cell. The cell can also take in material from outside by having vesicles pinch off from the cell membrane. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
11/4/2021 4:20:35 PM
11/4/2021 4:20:35 PM
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ITC_VesicTraffic_Copy_M Medium 143 KB 10/28/2020 12:49 PM McCulley, Jennifer (NIH/NIDCD) [C
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Cells progress through a cycle that consists of phases for growth (blue, green, yellow) and division (red). Cells become quiescent when they exit this cycle (purple). Featured in <a href=http://www.nigms.nih.gov/Publications/Findings.htm target="_blank"><i>Findings</i></a>, February 2003.
3/4/2022 8:24:29 PM
3/4/2022 8:24:29 PM
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