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NIH RePORTER
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Dashboard of TWD Funded Programs
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Workforce Developement
Related Information
Contact Information
Division Structure and Programs
Resources
Enhancing Diversity in Training Programs
FAQs About Noncompliance and Withdrawal of Applications
Laboratory Safety and Guidelines
Training Resources
Capacity Building
Division for Research Capacity Building
Institutional Development Award (IDeA)
Native American Research Centers for Health (NARCH)
Science Education Partnership Awards (SEPA)
Support of Competitive Research (SCORE)
Related Information
DRCB News
DRCB Staff Contacts
Resources
NIH RePORTER
Grants and Funding
Funding Opportunities
Current NIGMS Funding Opportunities
Parent Announcements for Investigator-Initiated Applications
Research Funding
Research Project Grants (NIH Parent R01)
Research With Activities Related to Diversity (ReWARD)
Maximizing Investigators' Research Awards (MIRA)
Instrumentation Grant Program for Resource-Limited Institutions (RLI-S10)
Undergraduate-Focused Institutions
Small Business Research
Multidisciplinary Teams/Collaborative Research
Technology Development
Research Resources
Clinical Studies and Trials
Conferences and Scientific Meetings
Administrative Supplements
All Funding Opportunities
Grant Application and Post-Award Information
How to Apply
Grant Application and Review Process
NIGMS Funding Policies
Post-Award Information
Talking to NIH Staff About Your Application and Grant
Considerations for Multiple Principal Investigator (MPI) Applications
Resources
Attribution of NIH/NIGMS Support
Message to NIGMS Investigators
NIH RePORTER
Research Using Human Subjects or Specimens
Science Education
Explore by Topic
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Injury and Illness
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Biomedical Beat Blog
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Order Print Resources
Other Resources
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News
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1047
2995
Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). This image is part of a series of images: <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1048">image 1048</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1049">image 1049</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1050">image 1050</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1051">image 1051</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1052">image 1052</a>.
8/14/2020 5:54:53 PM
8/14/2020 5:54:53 PM
Type Name Media Type File Size Modified
triplet1_S Low 10 KB 9/8/2016 2:22 PM Varkala, Venkat (NIH/NIGMS) [C
Stereo triplet of a sea urchin embryo
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Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). This image is part of a series of images: <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1047">image 1047</a> , <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1048">image 1048</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1050">image 1050</a>, <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1051">image 1051</a> and <a href="https://imagesadminprod.nigms.nih.gov/index.cfm?event=viewDetail&imageID=1052">image 1052</a>.
8/14/2020 6:02:18 PM
8/14/2020 6:02:18 PM
Type Name Media Type File Size Modified
triplet3_S Low 8 KB 9/8/2016 2:18 PM Varkala, Venkat (NIH/NIGMS) [C
Stereo triplet of a sea urchin embryo
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Glial cells (stained green) in a fruit fly developing embryo have survived thanks to a signaling pathway initiated by neighboring nerve cells (stained red).
8/27/2020 8:56:25 PM
8/27/2020 8:56:25 PM
Type Name Media Type File Size Modified
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Sensory organs have cells equipped for detecting signals from the environment, such as odors. Receptors in the membranes of nerve cells in the nose bind to odor molecules, triggering a cascade of chemical reactions tranferred by G proteins into the cytoplasm. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 7:26:43 PM
10/28/2020 7:26:43 PM
Type Name Media Type File Size Modified
ITC_Olf_layout_copy_M Medium 101 KB 10/28/2020 3:25 PM McCulley, Jennifer (NIH/NIDCD) [C
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As an egg cell develops, a process called polarization controls what parts ultimately become the embryo's head and tail. This picture shows an egg of the fruit fly <i>Drosophila</i>. Red and green mark two types of signaling proteins involved in polarization. Disrupting these signals can scramble the body plan of the embryo, leading to severe developmental disorders. Featured in the September 19, 2006, issue of <a href=http://publications.nigms.nih.gov/biobeat/06-09-19/#1 target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 12:54:35 PM
10/29/2020 12:54:35 PM
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2309_cell_polarity_S Low 49 KB 3/29/2019 1:54 PM Constantinides, Stephen (NIH/NIGMS) [C
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A nanometer-sized biosensor can detect a single deadly bacterium in tainted ground beef. How? Researchers attached nanoparticles, each packed with thousands of dye molecules, to an antibody that recognizes the microbe <i>E. coli</i> O157:H7. When the nanoball-antibody combo comes into contact with the <i>E. coli</i> bacterium, it glows. Here is the transition, a single bacterial cell glows brightly when it encounters nanoparticle-antibody biosensors, each packed with thousands of dye molecules. Featured in the March 15, 2005, issue of <a href=http://publications.nigms.nih.gov/biobeat/05-09-20/#1 target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 1:07:28 PM
10/29/2020 1:07:28 PM
Type Name Media Type File Size Modified
finding_one_bug_M Medium 11 KB 6/3/2016 3:08 PM aamishral2 (NIH/NIGMS) [C
Here is the transition, a single
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These colorful, computer-generated ribbons show the backbone of a molecule that glows a fluorescent red. The molecule, called mStrawberry, was created by chemists based on a protein found in the ruddy lips of a coral. Scientists use the synthetic molecule and other "fruity" ones like it as a dye to mark and study cell structures. Featured in the April 18, 2007, issue of <a href=http://publications.nigms.nih.gov/biobeat/07-04-18/#1 target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 1:18:41 PM
10/29/2020 1:18:41 PM
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2317_FruitDyes_S Low 83 KB 3/29/2019 1:51 PM Constantinides, Stephen (NIH/NIGMS) [C
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This crystal structure shows a conserved hypothetical protein from <i>Mycobacterium tuberculosis</i>. Only 12 other proteins share its sequence homology, and none has a known function. This structure indicates the protein may play a role in metabolic pathways. Featured as one of the August 2007 Protein Structure Initiative Structures of the Month.
10/29/2020 2:48:36 PM
10/29/2020 2:48:36 PM
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2343_Mtuberculosis_S Low 127 KB 3/29/2019 1:42 PM Constantinides, Stephen (NIH/NIGMS) [C
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Structure of a magnesium transporter protein from an antibiotic-resistant bacterium (<i>Enterococcus faecalis</i>) found in the human gut. Featured as one of the June 2007 Protein Sructure Initiative Structures of the Month.
10/29/2020 2:58:36 PM
10/29/2020 2:58:36 PM
Type Name Media Type File Size Modified
2345_nysgrc0618071_thumbnail Thumbnail 83 KB 3/4/2019 3:32 PM Constantinides, Stephen (NIH/NIGMS) [C
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An NMR solution structure model of the transfer RNA splicing enzyme endonuclease in humans (subunit Sen15). This represents the first structure of a eukaryotic tRNA splicing endonuclease subunit.
10/29/2020 3:06:53 PM
10/29/2020 3:06:53 PM
Type Name Media Type File Size Modified
2351_hi_2gw6_S Low 93 KB 3/29/2019 11:48 AM Constantinides, Stephen (NIH/NIGMS) [C
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Model of aspartoacylase, a human enzyme involved in brain metabolism.
10/29/2020 3:08:25 PM
10/29/2020 3:08:25 PM
Type Name Media Type File Size Modified
2352_hi_2i3c_S Low 113 KB 3/29/2019 11:47 AM Constantinides, Stephen (NIH/NIGMS) [C
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Model of an enzyme, dUTP pyrophosphatase, from <i>Mycobacterium tuberculosis</i>. Drugs targeted to this enzyme might inhibit the replication of the bacterium that causes most cases of tuberculosis.
10/29/2020 4:45:35 PM
10/29/2020 4:45:35 PM
Type Name Media Type File Size Modified
2381_hi_Rv2697c_S Low 120 KB 3/29/2019 11:31 AM Constantinides, Stephen (NIH/NIGMS) [C
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Actin (purple), microtubules (yellow), and nuclei (green) are labeled in these cells by immunofluorescence. This image won first place in the Nikon 2003 Small World photo competition.
8/17/2020 9:33:48 PM
8/17/2020 9:33:48 PM
Type Name Media Type File Size Modified
Wittmann1_S Low 88 KB 9/7/2016 3:02 PM Varkala, Venkat (NIH/NIGMS) [C
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A light microscope image of a cell from the endosperm of an African globe lily (<i>Scadoxus katherinae</i>). This is one frame of a time-lapse sequence that shows cell division in action. The lily is considered a good organism for studying cell division because its chromosomes are much thicker and easier to see than human ones. Staining shows microtubules in red and chromosomes in blue. Here, condensed chromosomes are clearly visible and are starting to line up.
5/9/2022 1:46:20 PM
5/9/2022 1:46:20 PM
Type Name Media Type File Size Modified
lilymit6_S Low 13 KB 9/8/2016 2:35 PM Varkala, Venkat (NIH/NIGMS) [C
Here, condensed chromosomes are clearly visible and are starting to line up
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Two models for how material passes through the Golgi apparatus: the vesicular shuttle model and the cisternae maturation model. You can see animations of the two different models at <a href="http://publications.nigms.nih.gov/insidethecell/extras/" target="_blank">http://publications.nigms.nih.gov/insidethecell/extras/</a>. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 4:37:04 PM
10/28/2020 4:37:04 PM
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ITC_GolgiTheories_S Low 69 KB 8/24/2016 5:17 PM Varkala, Venkat (NIH/NIGMS) [C
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Cells function within organs and tissues, such as the lungs, heart, intestines, and kidney. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 4:39:12 PM
10/28/2020 4:39:12 PM
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Nerve cells have long, invisibly thin fibers that carry electrical impulses throughout the body. Some of these fibers extend about 3 feet from the spinal cord to the toes. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 8:33:07 PM
10/28/2020 8:33:07 PM
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Model of a member from the Tex protein family, which is implicated in transcriptional regulation and highly conserved in eukaryotes and prokaryotes. The structure shows significant homology to a human transcription elongation factor that may regulate multiple steps in mRNA synthesis.
10/29/2020 2:37:40 PM
10/29/2020 2:37:40 PM
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NMR solution structure of a plant protein that may function in host defense. This protein was expressed in a convenient and efficient wheat germ cell-free system. Featured as the June 2007 Protein Structure Initiative Structure of the Month.
10/29/2020 2:40:04 PM
10/29/2020 2:40:04 PM
Type Name Media Type File Size Modified
hi_2g02_L Low 70 KB 6/3/2016 3:09 PM aamishral2 (NIH/NIGMS) [C
Featured as the June 2007 Protein Structure
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This is the first structure of a protein derived from the metagenomic sequences collected during the Sorcerer II Global Ocean Sampling project. The crystal structure shows a barrel protein with a ferredoxin-like fold and a long chain fatty acid in a deep cleft (shaded red). Featured as one of the August 2007 Protein Structure Initiative Structures of the Month.
10/29/2020 2:41:27 PM
10/29/2020 2:41:27 PM
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X-ray structure of a new DNA repair enzyme superfamily representative from the human gastrointestinal bacterium <i>Enterococcus faecalis</i>. European scientists used this structure to generate homologous structures. Featured as the May 2007 Protein Structure Initiative Structure of the Month.
10/29/2020 2:46:36 PM
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Crystal structure of oligoendopeptidase F, a protein slicing enzyme from <i>Bacillus stearothermophilus</i>, a bacterium that can cause food products to spoil. The crystal was formed using a microfluidic capillary, a device that enables scientists to independently control the parameters for protein crystal nucleation and growth. Featured as one of the July 2007 Protein Structure Initiative Structures of the Month.
10/29/2020 4:30:39 PM
10/29/2020 4:30:39 PM
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A knotted protein from an archaebacterium called <i>Methanobacterium thermoautotrophicam</i>. This organism breaks down waste products and produces methane gas. Protein folding theory previously held that forming a knot was beyond the ability of a protein, but this structure, determined at Argonne's Structural Biology Center, proves differently. Researchers theorize that this knot stabilizes the amino acid subunits of the protein.
10/29/2020 4:32:27 PM
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A crystal of porcine trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures.
8/6/2020 7:45:47 PM
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Ionic and covalent bonds hold molecules, like sodium chloride and chlorine gas, together. Hydrogen bonds among molecules, notably involving water, also play an important role in biology. Featured in <a href=http://publications.nigms.nih.gov/chemhealth/ target="_blank"><i>The Chemistry of Health</i></a>.
3/4/2022 8:07:52 PM
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The plasma membrane is a cell's protective barrier Featured in <a href=http://publications.nigms.nih.gov/chemhealth/ target="_blank"><i>The Chemistry of Health</i></a>.
3/4/2022 8:02:56 PM
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NIGMS staff are located in the Natcher Building on the NIH campus.
8/27/2020 8:21:36 PM
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NIGMS staff are located in the Natcher Building on the NIH campus.
8/27/2020 8:26:41 PM
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Alisa Machalek, National Institute of General Medical Sciences
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Signal obtained by allowing proteins in human serum to interact with glycan (polysaccharide) arrays. The arrays are shown in replicate so the pattern is clear. Each spot contains a specific type of glycan. Proteins have bound to the spots highlighted in green.
10/28/2020 4:09:56 PM
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The cone cell of the eye allows you to see in color. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
2/6/2020 4:53:23 PM
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The three fibers of the cytoskeleton--microtubules in blue, intermediate filaments in red, and actin in green--play countless roles in the cell. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 4:14:44 PM
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Like a watch wrapped around a wrist, a special enzyme encircles the double helix to repair a broken strand of DNA. Without molecules that can mend such breaks, cells can malfunction, die, or become cancerous. Featured in the November 21, 2006, issue of <a href=http://publications.nigms.nih.gov/biobeat/06-11-21/#1 target="_blank"><em>Biomedical Beat</em></a>. Related to image <a href="https://imagesadminprod.nigms.nih.gov/Pages/DetailPage.aspx?imageID=561">3493</a>
10/29/2020 2:16:53 PM
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Like a world of its own, this sphere represents all the known chemical reactions in the <i>E. coli</i> bacterium. The colorful circles on the surface symbolize sets of densely interconnected reactions. The lines between the circles show additional connecting reactions. The shapes inside the circles are landmark molecules, like capital cities on a map, that either act as hubs for many groups of reactions, are highly conserved among species, or both. Molecules that connect far-flung reactions on the sphere are much more conserved during evolution than molecules that connect reactions within a single circle. This statistical cartography could reveal insights about other complex systems, such as protein interactions and gene regulation networks. Featured in the August 16, 2005, issue of <a href=http://publications.nigms.nih.gov/biobeat/05-08-16/#1 target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 2:23:35 PM
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The goal of the PSI is to determine the three-dimensional shapes of a wide range of proteins by solving the structures of representative members of each protein family found in nature. The collection of structures should serve as a valuable resource for biomedical research scientists.
10/29/2020 4:12:18 PM
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This slide shows the technologies that the Joint Center for Structural Genomics developed for going from gene to structure and how the technologies have been integrated into a high-throughput pipeline, including all of the steps from target selection, parallel expression, protein purification, automated crystallization trials, automated crystal screening, structure determination, validation, and publication.
10/29/2020 4:14:36 PM
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A global "map of the protein structure universe" indicating the positions of specific proteins. The preponderance of small, less-structured proteins near the origin, with the more highly structured, large proteins towards the ends of the axes, may suggest the evolution of protein structures.
10/29/2020 4:18:37 PM
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A crystal of RNase A protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures.
8/6/2020 6:44:52 PM
8/6/2020 6:44:52 PM
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<i>Borrelia burgdorferi</i> is a spirochete, a class of long, slender bacteria that typically take on a coiled shape. Infection with this bacterium causes Lyme disease.
3/13/2023 7:26:43 PM
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Colorized scanning electron micrographs progressively zoom in on the eye of a crab larva. In the higher-resolution frames, bacteria are visible on the eye.
3/13/2023 7:24:39 PM
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Cells keep time to know when to retire. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 7:49:32 PM
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A cell in anaphase during mitosis: Chromosomes separate into two genetically identical groups and move to opposite ends of the spindle. Mitosis is responsible for growth and development, as well as for replacing injured or worn out cells throughout the body. For simplicity, mitosis is illustrated here with only six chromosomes. Appears in the NIGMS booklet <a href="http://publications.nigms.nih.gov/insidethecell/" target="_blank"><i>Inside the Cell</i></a>.
10/28/2020 8:03:57 PM
10/28/2020 8:03:57 PM
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How far and fast an infectious disease spreads across a community depends on many factors, including transportation. These U.S. maps, developed as part of an international study to simulate and analyze disease spread, chart daily commuting patterns. They show where commuters live (top) and where they travel for work (bottom). Green represents the fewest number of people whereas orange, brown, and white depict the most. Such information enables researchers and policymakers to visualize how an outbreak in one area can spread quickly across a geographic region. Featured in the August 15, 2007, issue of <a href=http://publications.nigms.nih.gov/biobeat/07-08-15/#1 target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 1:48:39 PM
10/29/2020 1:48:39 PM
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In 2006, scientists developed an optical microscopy technique enabling them to clearly see individual molecules within cells. In 2007, they took the technique, abbreviated STORM, a step further. They identified multicolored probes that let them peer into cells and clearly see multiple cellular components at the same time, such as these microtubules (green) and small hollows called clathrin-coated pits (red). Unlike conventional methods, the multicolor STORM technique produces a crisp and high resolution picture. A sharper view of how cellular components interact will likely help scientists answer some longstanding questions about cell biology. Featured in the October 17, 2007, issue of <a href=http://publications.nigms.nih.gov/biobeat/07-10-17/#1 target="_blank"><em>Biomedical Beat</em></a>.
10/29/2020 2:02:16 PM
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A crystal of sheep hemoglobin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures.
10/29/2020 4:58:13 PM
10/29/2020 4:58:13 PM
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A crystal of porcine trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures.
8/6/2020 4:08:55 PM
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<i>Hydra magnipapillata</i> is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis.
8/19/2020 2:54:54 PM
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Glucose (top) and sucrose (bottom) are sugars made of carbon, hydrogen, and oxygen atoms. Carbohydrates include simple sugars like these and are the main source of energy for the human body. Featured in <a href=http://www.nigms.nih.gov/Publications/Findings.htm target="_blank"><i>Findings</i></a>, October 2004.
9/18/2020 5:38:14 PM
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Dose-response curves determine how much of a drug (X-axis) causes a particular effect, or a side effect, in the body (Y-axis). Featured in <a href=http://publications.nigms.nih.gov/medbydesign/ target="_blank"><i>Medicines By Design</i></a>.
10/9/2020 4:27:14 PM
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2533_Dose_Response_S Low 129 KB 3/29/2019 11:21 AM Constantinides, Stephen (NIH/NIGMS) [C
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The 46 human chromosomes are shown in blue, with the telomeres appearing as white pinpoints. The DNA has already been copied, so each chromosome is actually made up of two identical lengths of DNA, each with its own two telomeres.
11/6/2020 8:58:08 PM
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telomere_FISH_M Medium 31 KB 11/6/2020 4:02 PM Walter, Taylor (NIH/NIGMS) [C
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This ribbon drawing of a protein hand drawn and colored by researcher Jane Richardson in 1981 helped originate the ribbon representation of proteins that is now ubiquitous in molecular graphics. The drawing shows the 3-dimensional structure of the protein triose phosphate isomerase. The green arrows represent the barrel of eight beta strands in this structure and the brown spirals show the protein's eight alpha helices. A black and white version of this drawing originally illustrated a <a href=http://kinemage.biochem.duke.edu/teaching/anatax target="_blank">review article</a> in <i>Advances in Protein Chemistry</i>, volume 34, titled "Anatomy and Taxonomy of Protein Structures." The illustration was selected as Picture of The Day on the English Wikipedia for November 19, 2009. Other important and beautiful images of protein structures by Jane Richardson are available in her <a href=http://commons.wikimedia.org/wiki/User:Dcrjsr/gallery_of_protein_structure target="_blank">Wikimedia gallery</a>.
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TriosePhosphateIsomerase_Ribbon_pastel_photo_mat3_S1 Low 904 KB 6/3/2016 3:16 PM aamishral2 (NIH/NIGMS
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